Patch repair of deep wounds by mobilized fascia

Self-assembly of progenitor cells under the aegis of platelet factors facilitates human skin organoid formation and vascularized wound healing

“…S7d). CD26 (dipeptidyl peptidase-4) expression of mature hiPSC-FBs ranged from 20% to 40%, reminiscent of a neonatal fibroblast phenotype 38 (Fig. S6bc).…”

“…Ideally this will result in scar-free regeneration otherwise observed during fetal development 45 . We may speculate that reduced CD26 expression by hiPSC-FBs, reminiscent of the engrailed + non-scarring fetal fibroblast phenotype 38 , could indicate reduced scar formation risk after transplantation.…”

Ready-made cellular plugs heal skin wounds

“…At or near room temperature, the heat transfer between objects separated by a material medium occurs at a much higher rate when facilitated by phonons than by photons. However, phonons are generally thought to be ineffective at transporting heat between objects separated by a vacuum gap, because these energy carriers are vibrations in an atomic lattice and thus would require a 1 show that phonons -vibrations in an atomic lattice -can be transported between objects that are separated by a vacuum gap. To understand how this process occurs, consider an object at a fixed temperature T 1 .…”

“…However, it now seems that the fascia has roles beyond providing a non-stick surface. On page 287, Correa-Gallegos et al 1 report that the fascia contains a movable sealant that patches up deep injuries to enable rapid wound repair.…”

“…Superficial wounds no deeper than skin level can be repaired by cells called Engrailed-positive fibroblasts (EPFs) in the dermis, which make extracellular-matrix material. Working with mice, Correa-Gallegos et al1 investigated the healing of deep wounds that penetrated below the skin into a layer known as the fascia. The fascia contains EPFs, extracellular matrix, blood vessels, nerves and immune cells called macrophages.…”