Pasteurized <i>Akkermansia muciniphila</i> reduces periodontal and systemic inflammation induced by <i>Porphyromonas gingivalis</i> in lean and obese mice

Mulhall, Hannah; DiChiara, Jeanne M.; Huck, Olivier; Amar, Salomon

doi:10.1111/jcpe.13629

Cited by 23 publications

(17 citation statements)

References 35 publications

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“…Recently, pasteurized Akk has been shown to alleviate Porphyromonas gingivalis -induced periodontitis. In a study by Mulhall et al in lean and obese mice, P. gingivalis -associated periodontitis was induced by oral or gavage administration of live Akk (10^9), pasteurized Akk (10^9), and the Akk outer membrane protein Amuc_1100 (6 ug/mouse) for 3 weeks [ 60 ]. The results showed that live Akk bacteria, pasteurized Akk, and Amuc_1100 significantly reduced P. gingivalis -induced periodontal injury and inflammatory infiltration, decreased plasma TNF-α levels, and increased IL10 levels.…”

Section: Recent Pre-clinical and Clinical Postbiotic Studiesmentioning

confidence: 99%

The Current and Future Perspectives of Postbiotics

Liang

Xing

2023

Probiotics & Antimicro. Prot.

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With the emphasis on intestinal health, probiotics have exploded into a vast market potential. However, new scientific evidence points out that the beneficial health benefits of probiotics are not necessarily directly related to viable bacteria. However, the metabolites or bacterial components of the live bacteria are the driving force behind health promotion. Therefore, scientists gradually noticed that the beneficial effects of probiotics are based on bacteria itself, metabolites, or cell lysates, and these factors are officially named “postbiotics” by the ISAPP. Postbiotic components are diverse and outperform live probiotics in terms of technology, safety, and cost due to their good absorption, metabolism, and organismal distribution. Postbiotics have been shown to have bioactivities such as antimicrobial, antioxidant, anti-inflammatory, anti-proliferative, and immunomodulation. Moreover, numerous studies have revealed the significant potential of postbiotics for disease treatment. This paper first presents the production and classification of postbiotics with examples from lactic acid bacteria (LAB), followed by the mechanisms of action with the most recent pre-clinical and clinical studies and the wide range of non-clinical and clinical applications of postbiotics. Furthermore, the current and future prospects of the postbiotic market with commercial available products are discussed. Finally, we comment on the knowledge gaps and future clinical applications with several examples.

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Section: Recent Pre-clinical and Clinical Postbiotic Studiesmentioning

confidence: 99%

The Current and Future Perspectives of Postbiotics

Liang

Xing

2023

Probiotics & Antimicro. Prot.

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“…On the other hand, they can also enhance oral tolerance and prevent food allergy [ 96 ]. Experiments in mice have demonstrated that Akkermansia muciniphila helps to reduce TNF-α plasma levels and increase IL-10 in mice after pasteurization [ 97 ]. Clinical trials have demonstrated sublingual immunotherapy’s safety and clinical efficacy with heat-inactivated bacteria (MV130) for preventing respiratory tract infections [ 95 ].…”

Section: Postbiotics and Food Allergymentioning

confidence: 99%

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Huang

Liang

et al. 2023

Molecules

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Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

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“…Porphyromonas gingivalis 36 , suggesting that the addition of probiotics might be another effective channel of treatment.…”

Section: Pasteurized Akkermansia Muciniphila Reduced Periodontal and ...mentioning

confidence: 99%

The recovery of the microbial community after plaque removal depends on periodontal health status

Wang

et al. 2023

Preprint

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Plaque accumulation and microbial community changes are important causes of periodontal disease. Cleaned plaque microorganisms reattach to form biofilms, but the recovery and outcome of plaque microbial communities in different periodontal health states are still unknown. In this study, we tracked the biofilm remodeling process in 206 dental plaque samples from 40 healthy periodontal, gingivitis and periodontitis volunteers at 6 time points before and after supragingival scaling. We found that microbial communities of different periodontal states changed asynchronously during the process, and the more severe the periodontal disease condition, the more lagged the recovery of plaque microorganisms to their original state after cleaning; this reflected a higher degree of plaque development in periodontitis samples. The plaque index and bleeding index were found to be significantly correlated with plaque recovery, especially the recovery of bacteria such as Abiotrophia and Capnocytophaga. Meanwhile, we found that the microbial community structure of different periodontal health states was most similar at the Day 3 after plaque cleaning, and the communities gradually differentiated and developed in different directions. Abiotrophia and other bacteria might play an important role in determining the development trend of plaque biofilms. The discovery of specific time points and bacteria was of great value in clarifying the pathogenesis of periodontal disease and in seeking targets for prevention and treatment.

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Pasteurized Akkermansia muciniphila reduces periodontal and systemic inflammation induced by Porphyromonas gingivalis in lean and obese mice

Cited by 23 publications

References 35 publications

The Current and Future Perspectives of Postbiotics

The Current and Future Perspectives of Postbiotics

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

The recovery of the microbial community after plaque removal depends on periodontal health status

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