Pasteurella multocida as an Infectious Cause of Endocarditis

Elsaghier, A.; Kibbler, C C; Hamilton‐Miller, J. M. T.

doi:10.1086/517707

Cited by 7 publications

(7 citation statements)

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“…Leukocyte and neutrophil counts are typically high at the infection site, and inflammation develops very rapidly. In more severe cases, pasteurellosis can rapidly progress to bacteremia (fulminant sepsis) (41, 161,235,241,251,[256][257][258][259][260][261][262][263][264][265][266] and other complications such as osteomyelitis (inflammation of the bone) (155,165,(267)(268)(269), endocarditis (inflammation of the heart) (256,263,(270)(271)(272)(273)(274)(275)(276)(277)(278)(279)(280)(281)(282)(283)(284)(285), and meningitis (inflammation of the meninges) (53, 90, 159, 163, 165, 264, 286-293).…”

Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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SUMMARY In a world where most emerging and reemerging infectious diseases are zoonotic in nature and our contacts with both domestic and wild animals abound, there is growing awareness of the potential for human acquisition of animal diseases. Like other Pasteurellaceae , Pasteurella species are highly prevalent among animal populations, where they are often found as part of the normal microbiota of the oral, nasopharyngeal, and upper respiratory tracts. Many Pasteurella species are opportunistic pathogens that can cause endemic disease and are associated increasingly with epizootic outbreaks. Zoonotic transmission to humans usually occurs through animal bites or contact with nasal secretions, with P. multocida being the most prevalent isolate observed in human infections. Here we review recent comparative genomics and molecular pathogenesis studies that have advanced our understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections. We also summarize efforts being explored to enhance our ability to rapidly and accurately identify and distinguish among clinical isolates and to control pasteurellosis by improved development of new vaccines and treatment regimens.

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Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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“…However, the role of Pasteurella spp. as causative organisms in some of these cases was questioned as their identification was incomplete and potentially mistaken for Haemophilus spp., which are well recognized etiologic agents of endocarditis [20]. In our patient P. multocida was clearly identified by biochemical reactions (catalase and oxidase positivity) and by using API-NE ® (bioMérieux, Marcy l'Etoile, France).…”

Section: Discussionmentioning

confidence: 63%

Isolated Endocarditis of the Pulmonary Valve Caused by Pasteurella multocida

et al. 2007

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“…As the majority of our patients were not associated with animal trauma, respiratory tract was unsurprisingly the most common site of the infection (trancheobronchitis, 3; pneumonia, 5). Unusual sites such as endocarditis in native or prosthetic valves [5,13] , tonsillitis [14] , periocular abscess [15] and utero infection in pregnancy [16] have also been reported. There was also a case with an unexpected site of infection among our patients: the patient no.…”

Section: Discussionmentioning

confidence: 99%

“…Human infections due to P. multocida are strongly associated with animal exposure and usually involve soft-tissue sites after animal bites or scratches [2,3] . Respiratory tract infections and less frequently septicemia, endocarditis, meningitis, peritonitis, or other unusual types of infection due to this organism have also been described [4][5][6][7][8] . In this study we present 13 cases of P. multocida infection diagnosed in our hospital during a 12-year period.…”

Section: Pasteurellamentioning

confidence: 99%

Review of Pasteurella multocida Infections over a Twelve-Year Period in a Tertiary Care Hospital

Christidou¹,

Maraki²,

Gitti³

et al. 2005

American J. of Infectious Diseases

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Abstract:The aim of this study was to present the epidemiological, clinical and microbiological data, as well as the management and the outcome of 13 patients with documented Pasteurella multocida infections, diagnosed in the University hospital of Crete, Greece, between 1993 and 2004. Most patients (62%) were >70 years of age. Respiratory tract infections were most commonly encountered (61.5%), followed by soft-tissue infections (30.8%) and septicemia (7.7 %). Underlying diseases included malignancies, bullous pemphigoid, mitral valve stenosis, coronary disease, chronic obstructive pulmonary disease and intracranial hemorrhage. Antibiotic sensitivity testing showed that all P. multocida isolates were susceptible to beta-lactams, quinolones, chloramphenicol, tetracycline and trimethoprim/sulfamethoxazole. Antibiotics were administered to all 13 patients and a clinical response was observed in 77% of them. The overall mortality rate was 23% (3/13) but only 15.4% (2/13) died from the infection. Although rare, P. multocida infections should be suspected in patients reporting animal exposure, particularly in those with chronic underlying diseases.

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Pasteurella multocida as an Infectious Cause of Endocarditis

Cited by 7 publications

References 0 publications

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Isolated Endocarditis of the Pulmonary Valve Caused by Pasteurella multocida

Review of Pasteurella multocida Infections over a Twelve-Year Period in a Tertiary Care Hospital

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