Past, present and future of cardiovascular twin studies

Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Molnár, Andrea

doi:10.1016/j.crvasa.2014.07.005

Cited by 5 publications

(2 citation statements)

References 84 publications

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“…Better characterizing the heritable and environmental influences of health-related phenotypes is of great interest to healthcare practitioners, public policy thinkers and society members in general. Cardiovascular disease, for example, ranks consistently high among the most prevalent causes of death worldwide 36 . Cardiovascular disease is moderately heritable, with most recent estimates hovering between 40% and 60% 37 .…”

Section: Widely Studied Phenotypesmentioning

confidence: 99%

Behavioural genetics methods

2023

Nat Rev Methods Primers

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Section: Widely Studied Phenotypesmentioning

confidence: 99%

Behavioural genetics methods

2023

Nat Rev Methods Primers

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“…Monozygotic pairs have the same chromosomal DNA sequence, except for very small errors of DNA replication, while dizygotic pairs share many maternal and obstetric factors; however, the likelihood of sharing specific genetic variations is the same as that of non-twin siblings [8]. Therefore, twin studies play a pivotal role in the discovery of the genetic basis and risk factors of CAD [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Concomitant Coronary Artery Disease in Identical Twins: Case Report and Systematic Literature Review

Kamzolas,

Papazoglou,

Gemousakakis

et al. 2023

JCM

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Coronary artery disease (CAD) is multifactorial and strongly affected by genetic, epigenetic and environmental factors. Several studies have reported development of concomitant CAD in identical twins. We report a case in which a pair of Caucasian male monozygotic twins presented almost concomitantly with acute coronary syndrome (ACS) and had concordant coronary anatomy and identical site of occlusion. We performed a systematic literature review of PubMed, Web Of Science and Scopus databases from inception until 28 February 2023 of case reports/case series reporting the concomitant development of CAD in monozygotic twins. We found 25 eligible case reports with a total of 31 monozygotic twin pairs (including the case from our center) suffering from CAD and presenting (most of them simultaneously) with ACS (mean age of presentation: 45 ± 12 years, males: 81%). Coronary angiograms demonstrated lesion and anatomy concordance in 77% and 79% of the twin pairs, respectively. Screening for disease-related genetic mutations was performed in six twin pairs leading to the identification of five CAD-related genetic polymorphisms. This is the first systematic literature review of studies reporting identical twin pairs suffering from CAD. In summary, there is high concordance of coronary anatomy and clinical presentation between monozygotic twins. Future monozygotic twin studies—unbiased by age effects—can provide insights into CAD heritability being able to disentangle the traditional dyad of genetic and environmental factors and investigate the within-pair epigenetic drift.

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The Genetics of Coronary Heart Disease

Erdmann

Venegas

2019

Genetic Causes of Cardiac Disease

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Past, present and future of cardiovascular twin studies

Cited by 5 publications

References 84 publications

Behavioural genetics methods

Behavioural genetics methods

Concomitant Coronary Artery Disease in Identical Twins: Case Report and Systematic Literature Review

The Genetics of Coronary Heart Disease

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