Past infection by Chlamydia pneumoniae strain TWAR and asymptomatic carotid atherosclerosis

Melnick, Sandra; Shahar, Eyal; Folsom, Aaron R.; Grayston, J. T.; Sorlie, Paul D.; Wang, San Pin; Szklo, Moysés

doi:10.1016/0002-9343(93)90332-j

Cited by 224 publications

(92 citation statements)

References 25 publications

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“…263,264 The fact that seropositivity to Chlamydia does not seem to correlate to carotid atherosclerosis, as measured by duplex ultrasonography, 265,266 supports the notion that Chlamydia may participate in plaque progression and destabilization as opposed to initiation of atherosclerosis, which may be why there appears to be a relationship between serum antibody titers to C pneumoniae and stroke. [267][268][269][270] The benefit of eradicating C pneumoniae from carotid plaques with antibiotic therapy remains unclear. 271 Data linking infection with other pathogens, such as cytomegalovirus and herpes simplex virus, with atherosclerosis are not as robust as those for C pneumoniae.…”

Section: Inflammatory Processesmentioning

confidence: 99%

Primary Prevention of Ischemic Stroke

Goldstein¹,

Adams²,

Becker³

et al. 2001

Circulation

405

196

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Section: Inflammatory Processesmentioning

confidence: 99%

Primary Prevention of Ischemic Stroke

Goldstein¹,

Adams²,

Becker³

et al. 2001

Circulation

405

196

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“…It can cause acute and chronic pulmonary infections such as pneumonia, bronchitis, sinusitis and pharyngitis in both adults and children. 1 Several studies have documented an association between serologic evidence of C. pneumoniae infection and various forms of vascular disease, such as coronary heart disease, [2][3][4] carotid atherosclerotic lesions 5,6 and ischaemic cerebrovascular disease. 7 However, a number of studies have failed to establish such an association.…”

Section: Introductionmentioning

confidence: 99%

Increased prevalence of Chlamydophila pneumoniae but not Epstein–Barr antibodies in essential hypertensives

et al. 2003

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Conflicting data exist regarding the relationship between Chlamydophila pneunoniae (C. pneumoniae) and hypertension. In this study, both C. pneumoniae IgG and IgA titres and Epstein-Barr virus antibody levels were measured in 146 sustained hypertensives defined by 24 h ambulatory blood pressure monitoring (ABPM) and 54 normotensives. C. pneumoniae antibodies were measured by microimmunofluorescence test. IgGX80 and IgAX40 were defined as elevated antibody titres. Epstein-Barr antibodies were measured in order to investigate whether a possible association exists between hypertension and other, similarly widespread in the general population, intracellular microorganisms. All participants underwent casual blood pressure (BP) readings and 24 h ABPM. Subjects having mean 24 h systolic/diastolic ambulatory BP4125/80 mmHg, with or without antihypertensive medication were defined as hypertensives. Controls were free of any history or clinical evidence of hypertension, cardiovascular or pulmonary disease. Of the total participants, 77 hypertensives (52.7%) and 10 normotensives (18.5%) had IgA titres X40 (crosstabs Po0.000), whereas 76 hypertensives (52.1%) and 15 normotensives (27.8%) had IgG titres X80, (crosstabs Po0.002). No difference was found in Epstein-Barr antibodies, between hypertensives and normotensives. In conclusion, C. pneumoniae, but not Epstein-Barr, antibody levels were found significantly higher in sustained hypertensives, suggesting high frequency of chronic C. pneumoniae, infections in this specific group of patients.

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“…6 Several groups have demonstrated serological associations with coronary artery disease, [7][8][9][10] strokes and transient cerebral ischemia, 11 and asymptomatic carotid atherosclerosis. 12 Our study was designed to test the association of this organism with HT in the multiracial inner-city population of north and west Birmingham, UK, after adjustments for several potential confounding variables. We subjected the HT patients to echocardiography with estimation of LVMI.…”

mentioning

confidence: 99%

Chlamydia pneumoniae Antibodies in Severe Essential Hypertension

Cook

Lip²,

Davies³

et al. 1998

Hypertension

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Abstract-Several studies have implied an association between Chlamydia pneumoniae (C. pneumoniae) and cardiovascular disease. Our study was designed to determine whether this organism is associated with severe essential hypertension in a multiracial British population. Antibodies to C. pneumoniae were measured by microimmunofluorescence in 123 patients with chronic severe hypertension and 123 control subjects, matched for ethnic origin, age, sex, and smoking habit, admitted to the same hospital with various noncardiovascular, nonpulmonary disorders. Previous infection was defined by IgG 64 to 256, provided that there was no detectable IgM. Multiple regression analyses of matched and unmatched data were used to investigate the influences of antibody levels and potential confounding factors (ethnic origin, age, sex, smoking habit, diabetes mellitus, and social deprivation) on hypertension. A portion of the hypertensive patients underwent echocardiography, estimation of left ventricular mass index, and measurements of fibrinogen, D-dimer, and von Willebrand factor concentrations. Thirty-five percent of hypertensive patients and 17.9% of matched control subjects had antibody titers consistent with previous C. pneumoniae infection. The hypertensive patients differed significantly from their matched control subjects in their level of previous infection, with an odds ratio of 2.5 (95% confidence interval, 1.3 to 4.7). There were no significant differences in antibody levels between patients with left ventricular hypertrophy and those without it. Fibrinogen, D-dimer, and von Willebrand factor concentrations were not significantly associated with antibody levels. These data support an association of C. pneumoniae with severe essential hypertension. They provide no evidence of a predisposition to develop left ventricular hypertrophy in hypertensive patients with C. pneumoniae infection or of associations with hypercoagulability or endothelial dysfunction. (Hypertension. 1998;31:589-594.)

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Past infection by Chlamydia pneumoniae strain TWAR and asymptomatic carotid atherosclerosis

Cited by 224 publications

References 25 publications

Primary Prevention of Ischemic Stroke

Primary Prevention of Ischemic Stroke

Increased prevalence of Chlamydophila pneumoniae but not Epstein–Barr antibodies in essential hypertensives

Chlamydia pneumoniae Antibodies in Severe Essential Hypertension

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