1993
DOI: 10.1016/0002-9343(93)90332-j
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Past infection by Chlamydia pneumoniae strain TWAR and asymptomatic carotid atherosclerosis

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Cited by 224 publications
(92 citation statements)
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“…263,264 The fact that seropositivity to Chlamydia does not seem to correlate to carotid atherosclerosis, as measured by duplex ultrasonography, 265,266 supports the notion that Chlamydia may participate in plaque progression and destabilization as opposed to initiation of atherosclerosis, which may be why there appears to be a relationship between serum antibody titers to C pneumoniae and stroke. [267][268][269][270] The benefit of eradicating C pneumoniae from carotid plaques with antibiotic therapy remains unclear. 271 Data linking infection with other pathogens, such as cytomegalovirus and herpes simplex virus, with atherosclerosis are not as robust as those for C pneumoniae.…”
Section: Inflammatory Processesmentioning
confidence: 99%
“…263,264 The fact that seropositivity to Chlamydia does not seem to correlate to carotid atherosclerosis, as measured by duplex ultrasonography, 265,266 supports the notion that Chlamydia may participate in plaque progression and destabilization as opposed to initiation of atherosclerosis, which may be why there appears to be a relationship between serum antibody titers to C pneumoniae and stroke. [267][268][269][270] The benefit of eradicating C pneumoniae from carotid plaques with antibiotic therapy remains unclear. 271 Data linking infection with other pathogens, such as cytomegalovirus and herpes simplex virus, with atherosclerosis are not as robust as those for C pneumoniae.…”
Section: Inflammatory Processesmentioning
confidence: 99%
“…It can cause acute and chronic pulmonary infections such as pneumonia, bronchitis, sinusitis and pharyngitis in both adults and children. 1 Several studies have documented an association between serologic evidence of C. pneumoniae infection and various forms of vascular disease, such as coronary heart disease, [2][3][4] carotid atherosclerotic lesions 5,6 and ischaemic cerebrovascular disease. 7 However, a number of studies have failed to establish such an association.…”
Section: Introductionmentioning
confidence: 99%
“…6 Several groups have demonstrated serological associations with coronary artery disease, [7][8][9][10] strokes and transient cerebral ischemia, 11 and asymptomatic carotid atherosclerosis. 12 Our study was designed to test the association of this organism with HT in the multiracial inner-city population of north and west Birmingham, UK, after adjustments for several potential confounding variables. We subjected the HT patients to echocardiography with estimation of LVMI.…”
mentioning
confidence: 99%