Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation

Meng, Nan; Dong, Yanhong; Huo, Tiantian; Song, Meiyi; Jiang, Xin; Xiao, Yining; Lv, Pei

doi:10.1007/s10571-020-00992-2

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…Several studies have shown that lower M10 values representing lower daily activity indices and higher L5 values representing higher nocturnal activity indices are associated with increased inflammatory markers ( 29 – 31 ). A recent pre-clinical study reported that neuroinflammation exacerbates cognitive impairment in a rat model of vascular dementia ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Association between rest-activity rhythm and cognitive function in the elderly: The U.S. National Health and Nutrition Examination Survey, 2011-2014

Sun

Wang²,

Wang³

et al. 2023

Front. Endocrinol.

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BackgroundCircadian rhythm plays an essential role in various physiological and pathological processes related to cognitive function. The rest-activity rhythm (RAR) is one of the most prominent outputs of the circadian system. However, little is known about the relationships between RAR and different domains of cognitive function in older adults. The purpose of this study was to examine the relationships between RAR and various fields of cognitive function in older Americans.MethodsThis study included a total of 2090 older adults ≥ 60 years old from the National Health and Nutrition Examination Survey (NHANES) in 2011-2014. RAR parameters were derived from accelerometer recordings. Cognitive function was assessed using the word learning subtest developed by the Consortium to Establish a Registry for Alzheimer’s disease (CERAD W-L), the Animal Fluency Test (AFT) and the Digital Symbol Substitution Test (DSST). Linear regression was used to determine the relationships between RAR parameters (IS, IV, RA, L5, M10) and cognitive function scores (CERAD W-L, AFT, DSST).ResultsAfter adjusting for potential confounders, lower IS and M10 were associated with lower CERAD W-L scores (P=0.033 and P=0.002, respectively). Weaker RA and higher L5 were associated with lower AFT scores (P<0.001 and P=0.001, respectively). And lower IS, RA, and higher L5 were associated with lower DSST scores (P=0.019, P<0.001 and P<0.001, respectively). In addition, the results of sensitivity analysis were similar to those of our main analyses. The main correlation results between the RAR indicators and cognitive function were robust.ConclusionsThis study suggested that the weakened and/or disrupted RAR was associated with cognitive decline in different domains in Americans over the age of 60.

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Section: Discussionmentioning

confidence: 99%

Association between rest-activity rhythm and cognitive function in the elderly: The U.S. National Health and Nutrition Examination Survey, 2011-2014

Sun

Wang²,

Wang³

et al. 2023

Front. Endocrinol.

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“…In the present study, one potential mechanism to explain the relationship between smoking and cognitive function is the inflammatory response, which may cause adverse effects on cognitive function ( 23 – 27 ). For example, a recent preclinical study reported that exposure to smoking exacerbates cognitive impairment in a rat model of vascular dementia through neuroinflammation ( 28 ). Another mechanism might involve psychosocial processes, such as sleep problems.…”

Section: Discussionmentioning

confidence: 99%

Smoking Status and Cognitive Function in a National Sample of Older Adults

Zhang

Chen

et al. 2022

Front. Psychiatry

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AimsTo examine the correlation between smoking status and different domains of cognitive function in elderly Americans.MethodsWe used data from the 2011 to 2014 U.S. National Health and Nutrition Examination Survey (NHANES). Participants over 60 years with available smoking history and cognitive function data were enrolled in our analysis. The NHANES study included the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST) to assess cognition. Multivariate regression analyses were used to estimate the association between cigarette smoking and cognitive function.ResultsA total of 2,932 participants were enrolled in the analysis, including 372 (12.7%) current smokers, 1,115 (38%) former smokers, and 1,445 (49.3%) never smokers. Never smokers had in average 3.82 (95% CI, 2.21 to 5.43) points more than current smokers in the DSST, whereas former smokers had 3.12 (95% CI, 1.51 to 4.73) points more than current smokers. Besides, smoking was not associated with the results of the AFT or the CERAD test.ConclusionsThis study suggests that cigarette smoking is associated with processing speed among the American elderly.

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“…In MS, smoking enhances inflammatory responses resulting in an increased risk of developing the disease ( Alrouji et al, 2019 ). Smoking is also a risk factor for dementia and past exposure induces neuroinflammation and aggravates cognitive impairment via NLRP3 and eukaryotic translation initiation factor 2A pathways in animal models ( Meng et al, 2020 ). However, tobacco smokers have a reduced incidence or delayed onset of PD ( Thacker et al, 2007 ; Ritz et al, 2014 ), and acute smoking suppresses inflammatory cytokines and has also been considered protective for neuroinflammation in PD.…”

Section: Risk and Protective Factors For Neuroinflammation In Neurode...mentioning

confidence: 99%

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Kip

Parr‐Brownlie

2023

Front. Neurosci.

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Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people’s health and wellbeing. This focus has created lifestyles with high stress levels, associated with overconsumption of unhealthy foods and little exercise, which negatively affect people’s lives, and subsequently lead to the development of pathologies, including neurodegenerative and psychiatric disorders. Prioritizing a healthy lifestyle to maintain wellbeing may slow the onset or reduce the severity of pathologies. It is a win-win for everyone; for societies and for individuals. A balanced lifestyle is increasingly being adopted globally, with many doctors encouraging meditation and prescribing non-pharmaceutical interventions to treat depression. In psychiatric and neurodegenerative disorders, the inflammatory response system of the brain (neuroinflammation) is activated. Many risks factors are now known to be linked to neuroinflammation such as stress, pollution, and a high saturated and trans fat diet. On the other hand, many studies have linked healthy habits and anti-inflammatory products with lower levels of neuroinflammation and a reduced risk of neurodegenerative and psychiatric disorders. Sharing risk and protective factors is critical so that individuals can make informed choices that promote positive aging throughout their lifespan. Most strategies to manage neurodegenerative diseases are palliative because neurodegeneration has been progressing silently for decades before symptoms appear. Here, we focus on preventing neurodegenerative diseases by adopting an integrated “healthy” lifestyle approach. This review summarizes the role of neuroinflammation on risk and protective factors of neurodegenerative and psychiatric disorders.

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Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation

Cited by 8 publications

References 48 publications

Association between rest-activity rhythm and cognitive function in the elderly: The U.S. National Health and Nutrition Examination Survey, 2011-2014

Association between rest-activity rhythm and cognitive function in the elderly: The U.S. National Health and Nutrition Examination Survey, 2011-2014

Smoking Status and Cognitive Function in a National Sample of Older Adults

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

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