We present a global synthesis of the evolution of the climate/ocean system from the late Campanian at approximately 75 Ma to the end of the Maastrichtian at 65 Ma. This study is based on published and new oxygen and carbon isotope data of benthic and planktic foraminifera from a number of deep-sea sites, spanning the high to the low latitudes. Most of the sites were at depths that in the modern oceans are bathed by intermediate-water masses. The δ 18 O records of planktic and benthic foraminifera from most locations indicate that surface and intermediate waters cooled during the period 75 to 65.5 Ma, particularly at high latitudes. Model surface-water temperatures, based on δ 18 O values averaged for 1-m.y. intervals at each of the sites and corrected for the latitudinal variation of seawater δ 18 O using the present seawater latitudinal δ 18 O variation, indicate that the latitudinal thermal gradient increased from 10 to 13°C. Superimposed on the long-term trend there were two episodes during which, on a global scale, benthic foraminiferal δ 18 O values increased substantially, and then decreased. The first episode occurred between 71 and 69.5 Ma; the second began between 68 and 67.5 Ma, and terminated at about 65.5 Ma. During the first episode, the thermohaline circulation changed, and cool intermediate depth waters derived from high-latitude regions penetrated temporarily to the tropics, resulting in tropical Pacific intermediate waters becoming cooler than those in the high southern latitudes. Benthic foraminiferal δ 13 C values suggest that these cool waters may have been derived from high northern latitudes. The level of the carbonate compensation depth (CCD) shallowed substantially in the Pacific, Indian, and South Atlantic basins, although surface-water productivity may have increased during the time of altered thermohaline circulation. At the same time, the CCD deepened in the North Atlantic, where deep waters were warm and salty, and formed locally. From 67.5 to 65.5 Ma, intermediate waters in the southern high latitudes were cooler than those in other basins, indicating that the thermohaline circulation operated on a mode more similar to the present circulation. Both episodes of cooler intermediate water can be correlated with eustatic sea-level curves, suggesting that sea level was the most likely mechanism to change the circulation and/or source(s) of intermediate-deep waters. At 65.5 Ma, surface and intermediate waters warmed globally by about 3-4°C, and then cooled slightly at about 65.1 Ma. We suggest this increase in marine temperatures correlates with the timing of the main episode of Deccan Trap flood basalt eruptions and may have been caused by greenhouse global warming.