Passive transfer of fibromyalgia symptoms from patients to mice

Is fibromyalgia an autoimmune illness?

“…Fibromyalgia patients IgG was exclusively accumulated in mice dorsal root ganglia (DRG). Among DRG components, satellite glial cells were the main IgG antigenic target [6]. With this new ground-breaking information, a key investigational issue emerges; is fibromyalgia a primarily autoimmune illness?…”

Broken Connections: The Evidence for Neuroglial Failure in ME/CFS

“…Concomitantly, the neuroglia seems to be functionally transformed into an activated, pathological state: "We discover microglia and astrocyte subpopulations associated with COVID-19 that share features with pathological cell states that have previously been reported in human neurodegenerative disease" (and, as a possibly important addition from very recent research, in fibromyalgia -which seems to be another member of the "fatigue family" in which activated neuroglia seems to be of central importance). 2 This explanation may fit well with imaging studies of PASC patients that have shown severely disrupted brain hyperconnectivity ("increased functional connectivity among regions of several resting-state networks" 377 ) -somewhat reminiscent of the findings of Barnden et al in ME/CFS 6 as well as hypometabolism in certain regulatory areas including the parahippocampal gyrus, thalamus, amygdala and, notably, brainstem and pons. 381,457,458 Basically, here the same regions of interest emerge as in ME/CFS research.…”

“…254 The autoimmune hypothesis has recently been strengthened by experimental work on Fibromyalgia which has identified a component of IgG as the symptom inducing factor. 2 It is plausible that the component in question may be an autoantibody (so far not identified in a very broad survey of candidate autoantibodies). At any rate, the factor apparently binds mainly to satellite glial cells in the dorsal root ganglia (a pathomechanism which is commensurate with the clinical manifestations of the syndrome).…”

“…In fibromyalgia, the glial compartment in the dorsal root ganglia has now to be considered the prime candidate as the central pathological hub, and there is overwhelming evidence that it may be stimulated by an autoantibody. 2 May a similar process be at work in ME/CFS? We don´t know, but this is possible (even if the process in ME/CFS more plausibly may be directed against glial targets in the CNS).…”

La fibromialgia: posible enfermedad autoinmune

“…Goebel y cols. publicaron recientemente los resultados de un estudio experimental en ratones hembra, a los que administraron IgG de pacientes con FM, y de controles sanos (5). Los ratones tratados con IgG de pacientes con FM mostraron una hiperalgesia a la estimulación mecánica y fría nociva, y las fibras nociceptivas, en las preparaciones de los nervios de la piel de ratones tratados con IgG de FM, mostraron una mayor capacidad de respuesta a los estímulos mecánicos y al frío.…”