Passive sampling devices enable capacity building and characterization of bioavailable pesticide along the Niger, Senegal and Bani Rivers of Africa

Anderson, Kim A.; Seck, Dogo; Hobbie, Kevin A.; Traore, Anna Ndiaye; McCartney, Melissa A.; Ndaye, Adama; Forsberg, Norman D.; Haigh, Theodore; Sower, Gregory J.

doi:10.1098/rstb.2013.0110

Cited by 37 publications

(36 citation statements)

References 36 publications

(67 reference statements)

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“…Pesticide exposures were measured using wristband personal sampling devices (PSD) containing membranes that adsorb a large range of organic chemicals from any media they contact [33]. The wristbands concentrate organic compounds over time, which improves detection limits and reflects episodic exposures.…”

Section: Discussionmentioning

confidence: 99%

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Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children

Vidi

Anderson

Chen

et al. 2017

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Agriculture in the United States employs youth ages ten and older in work environments with high pesticide levels. Younger children in rural areas may also be affected by indirect pesticide exposures. The long-term effects of pesticides on health and development are difficult to assess and poorly understood. Yet, epidemiologic studies suggest associations with cancer as well as cognitive deficits. We report a practical and cost-effective approach to assess environmental pesticide exposures and their biological consequences in children. Our approach combines silicone wristband personal samplers and DNA damage quantification from hair follicles, and was tested as part of a community-based participatory research (CBPR) project involving ten Latino children from farmworker households in North Carolina. Our study documents high acceptance among Latino children and their caregivers of these noninvasive sampling methods. The personal samplers detected organophosphates, organochlorines, and pyrethroids in the majority of the participants (70%, 90%, 80%, respectively). Pesticides were detected in all participant samplers, with an average of 6.2 ± 2.4 detections/participant sampler. DNA damage in epithelial cells from the sheath and bulb of plucked hairs follicles was quantified by immunostaining 53BP1-labled DNA repair foci. This method is sensitive, as shown by dose response analyses to γ radiations where the lowest dose tested (0.1 Gy) led to significant increased 53BP1 foci density. Immunolabeling of DNA repair foci has significant advantages over the comet assay in that specific regions of the follicles can be analyzed. In this cohort of child participants, significant association was found between the number of pesticide detections and DNA damage in the papilla region of the hairs. We anticipate that this monitoring approach of bioavailable pesticides and genotoxicity will enhance our knowledge of the biological effects of pesticides to guide education programs and safety policies.

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Section: Discussionmentioning

confidence: 99%

“…Exposures were measured using wristband personal sampling devices [33] worn by the participants. Each wristband was cleaned of particulate matter by rinsing twice with 18 MΩ*cm water and once with isopropanol.…”

Section: Methodsmentioning

confidence: 99%

Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children

Vidi

Anderson

Chen

et al. 2017

Mutation Research/Genetic Toxicology and Environmental Mutagene

Self Cite

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“…Specific method details can be found for PAH (Allan et al, 2012), OPAH (O’Connell et al, 2013), and pesticide (Anderson et al, 2014) analyses published previously. Internal standards for each method were spiked into extract aliquots just prior to instrumental analyses.…”

Section: Methodsmentioning

confidence: 99%

“…Internal standards for each method were spiked into extract aliquots just prior to instrumental analyses. A gas chromatograph (GC) with an Agilent DB-5 column (30 m length, 0.25 mm inner diameter, 0.25 μm film thickness) was used to analyze OPAHs and PAHs (2010 deployment), while an Agilent DB-XLB (30m, 0.25mm, 0.25 μm) and a DB-17MS (30m, 0.25mm, 0.25 μm) was used to analyze pesticides with dual column confirmation (Anderson et al, 2014). An Agilent Select PAH column (30m, 0.25mm, 0.15 μm) was used for PAHs in the 2011 deployment.…”

Section: Methodsmentioning

confidence: 99%

Improvements in pollutant monitoring: Optimizing silicone for co-deployment with polyethylene passive sampling devices

O’Connell

McCartney

Paulik

et al. 2014

Environmental Pollution

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Sequestering semi-polar compounds can be difficult with low-density polyethylene (LDPE), but those pollutants may be more efficiently absorbed using silicone. In this work, optimized methods for cleaning, infusing reference standards, and polymer extraction are reported along with field comparisons of several silicone materials for polycyclic aromatic hydrocarbons (PAHs) and pesticides. In a final field demonstration, the most optimal silicone material is coupled with LDPE in a large-scale study to examine PAHs in addition to oxygenated-PAHs (OPAHs) at a Superfund site. OPAHs exemplify a sensitive range of chemical properties to compare polymers (log Kow 0.2–5.3), and transformation products of commonly studied parent PAHs. On average, while polymer concentrations differed nearly 7-fold, water-calculated values were more similar (about 3.5-fold or less) for both PAHs (17) and OPAHs (7). Individual water concentrations of OPAHs differed dramatically between silicone and LDPE, highlighting the advantages of choosing appropriate polymers and optimized methods for pollutant monitoring.

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“…Although there is very low residual uncertainty associated with these pesticide risks to human health and the environment throughout West Africa [8], direct measurements of personal exposure have not yet been published. The lack of direct analysis of human and environmental exposures is a result of low capacity for chemical analysis in the region, and the limited suitability of many of the available methods of monitoring [6,9]. …”

Section: Introductionmentioning

confidence: 99%

Silicone wristbands detect individuals' pesticide exposures in West Africa

et al. 2016

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We detected between 2 and 10 pesticides per person with novel sampling devices worn by 35 participants who were actively engaged in farming in Diender, Senegal. Participants were recruited to wear silicone wristbands for each of two separate periods of up to 5 days. Pesticide exposure profiles were highly individualized with only limited associations with demographic data. Using a 63-pesticide dual-column gas chromatography–electron capture detector (GC-ECD) method, we detected pyrethoid insecticides most frequently, followed by organophosphate pesticides which have been linked to adverse health outcomes. This work provides the first report of individualized exposure profiles among smallholder farmers in West Africa, where logistical and practical constraints have prevented the use of more traditional approaches to exposure assessment in the past. The wristbands and associated analytical method enabled detection of a broad range of agricultural, domestic, legacy and current-use pesticides, including esfenvalerate, cypermethrin, lindane, DDT and chlorpyrifos. Participants reported the use of 13 pesticide active ingredients while wearing wristbands. All six of the pesticides that were both reportedly used and included in the analytical method were detected in at least one wristband. An additional 19 pesticide compounds were detected beyond those that were reported to be in use, highlighting the importance of measuring exposure in addition to collecting surveys and self-reported use records. The wristband method is a candidate for more widespread use in pesticide exposure and health monitoring, and in the development of evidence-based policies for human health protection in an area where food security concerns are likely to intensify agricultural production and pesticide use in the near future.

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Passive sampling devices enable capacity building and characterization of bioavailable pesticide along the Niger, Senegal and Bani Rivers of Africa

Cited by 37 publications

References 36 publications

Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children

Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children

Improvements in pollutant monitoring: Optimizing silicone for co-deployment with polyethylene passive sampling devices

Silicone wristbands detect individuals' pesticide exposures in West Africa

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