A 69-year-old man was transported to the ED via emergency medical services after a family member discovered him alone at home and confused. His wife stated that her husband had been sick with the flu and had been febrile for the previous several days. The patient's blood pressure taken on the scene by the emergency medical technician was 80/40 mm Hg, and 1 L normal saline was infused during transport. Upon arrival to the ED, his vital signs were: temperature, 103.3°F; heart rate,130 beats/minute; BP, 90/48 mm Hg; and respiratory rate, 24 breaths/minute. Oxygen saturation was 92% on nasal canula. An electrocardiogram showed sinus tachycardia with nonspecific changes. Based on the patient's symptoms, the emergency physician (EP) suspected sep-sis and ordered the appropriate laboratory studies and radiographic images. During evaluation, the patient's systolic BP decreased to 70 from 80 mm Hg, and the EP ordered another fluid bolus and considered assessing the patient's volume status.