Passive immunization of mice against<i>Candida albicans</i>

Mourad, Sah'l; Friedman, Lorraine

doi:10.1080/00362176885190191

Cited by 79 publications

(2 citation statements)

References 5 publications

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“…Mourad and Friedman, in the 1960's, performed the initial controlled experiments that produced results suggesting that antibodies may be protective against disseminated candidiasis [54,55]. Interestingly, these investigators used whole fungal cells as the immunogen, and for unexplained reasons the mice produced unusually high antibody titers against the fungus, which may explain why these investigators observed protective antibody responses, whereas others did not for the ensuing ten years or so.…”

Section: A Brief Consideration As To Whether Antibodies Protect Againmentioning

confidence: 93%

Defining Criteria for Anti-Mannan Antibodies to Protect Against Candidiasis

Je¹

2005

CMM

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Prevention of hematogenously disseminated candidiasis and mucocutaneous disease, including Candida vaginitis, through immunological approaches is appealing for the following reason. A long-acting and safe vaccine that protects against both serotypes of Candida albicans and other important species, such as C. tropicalis and C. glabrata, should significantly reduce the incidence of various forms of candidiasis by these etiologic agents. Through extensive experimentation on protective responses in experimental animals against Candida mannan components, others and we have evidence that antibodies specific for short-chain beta-linked oligomannosides are protective against candidiasis. Although the mechanism of protection against vaginal infection requires further investigation, experimentally the ability of antibody to rapidly deposit high amounts of complement factor C3 onto the yeast cell wall is requisite for enhancing resistance against disseminated candidiasis.

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Section: A Brief Consideration As To Whether Antibodies Protect Againmentioning

confidence: 93%

Defining Criteria for Anti-Mannan Antibodies to Protect Against Candidiasis

Je¹

2005

CMM

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“…The role of humoral immunity in resistance to systemic C. albicans infection has been implicated by the transfer of immunity to recipients by immune sera (Mourad and Friedman, 1968;Al-Doory, 1970). In addition, the passive transfer of immune sera also protected mice against a localised thigh lesion (Pearsall, Adams and Bunni, 1978).…”

Section: Survival Of Immunised Mice After Challengementioning

confidence: 99%

Active immunisation of mice against muscle damage mediated by Candida albicans

Oblack

Holder

1979

Journal of Medical Microbiology

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Nonspecific and Candida-Specific Immune Responses in Mice Suppressed by Chronic Administration of Anti-μ

Kuruganti

Henderson

Garner

et al. 1988

Journal of Leukocyte Biology

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CBA/J mice were immunosuppressed by repeated administration of goat antibody specific for mu chain of immunoglobulin M (IgM) and tested for nonspecific and Candida albicans-specific immune responses. Immunosuppression was demonstrated by a dramatic reduction in the number of antibody-forming cells in the spleens of anti-mu-treated mice when immunized with sheep erythrocytes, by greatly reduced in vitro responsiveness of both spleen and lymph node lymphocytes from anti-mu-treated mice to lipopolysaccharide, and by a large reduction in the number of splenic IgM-positive cells. T cell function, on the other hand, appeared to be relatively unaltered in anti-mu-treated animals, in the cytotoxic T lymphocyte activity against an allogeneic target was similar in splenocyte cultures from anti-mu- and mock-treated animals, and splenic and lymph node lymphocytes proliferated in response to concanavalin A in a lymphocyte stimulation assay. Moreover, Candida-specific delayed hypersensitivity to two different Candida antigens, one cell wall-derived (GP) and the other cell membrane-derived (BEX), was of comparable intensity in immunosuppressed and normal animals. When anti-mu- and mock-treated mice were immunized by the cutaneous inoculation of viable C. albicans blastospores and then challenged intravenously to assess the development of protective immunity, only mock-treated animals, male and female, had significant (p less than or equal to 0.05) protective responses demonstrable by reduction in the number of colony-forming units cultured from their kidneys 28 days after intravenous challenge. If consideration was given to the number of animals which had cleared Candida completely from the kidney, however, there appeared to be protective responses operative in the female anti-mu-treated animals as well. Neither anti-mu-treated males nor females, when immunized and challenged with C. albicans, produced Candida-specific antibody detectable by counterimmunoelectrophoresis, whereas all immunized and challenged mock-treated animals produced antibody. The data are consistent with the hypothesis that anti-mu treatment has little effect on multiple cellular immune functions, including those specific for C. albicans, and the combination of antibody, cell-mediated immunity and innate defenses are responsible for solid systemic defense against the fungus.

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Passive immunization of mice againstCandida albicans

Cited by 79 publications

References 5 publications

Defining Criteria for Anti-Mannan Antibodies to Protect Against Candidiasis

Defining Criteria for Anti-Mannan Antibodies to Protect Against Candidiasis

Active immunisation of mice against muscle damage mediated by Candida albicans

Nonspecific and Candida-Specific Immune Responses in Mice Suppressed by Chronic Administration of Anti-μ

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