2000
DOI: 10.1177/10454411000110020101
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Passive Immunization Against Dental Caries and Periodontal Disease: Development of Recombinant and Human Monoclonal Antibodies

Abstract: Indigenous micro-organisms in the oral cavity can cause two major diseases, dental caries and periodontal diseases. There is neither agreement nor consensus as to the actual mechanisms of pathogenesis of the specific virulence factors of these micro-organisms. The complexity of the bacterial community in dental plaque has made it difficult for the single bacterial agent of dental caries to be determined. However, there is considerable evidence that Streptococcus mutans is implicated as the primary causative or… Show more

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Cited by 66 publications
(40 citation statements)
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References 156 publications
(81 reference statements)
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“…been reported in a rat model (35,36) and in human subjects (2). However, due to the difficulties associated with developing effective animal models and the multifaceted nature of periodontitis, passive immunization therapy against periodontitis has not been studied extensively (37). Gingipains degrade cytokines (10,11), components of the complement system (8,9), and several receptors, including macrophage CD14 (13,14,38) and T-cells CD4 and CD8 (39), thereby perturbing the host defense system and facilitating sustained colonization of P. gingivalis.…”
Section: Discussionmentioning
confidence: 99%
“…been reported in a rat model (35,36) and in human subjects (2). However, due to the difficulties associated with developing effective animal models and the multifaceted nature of periodontitis, passive immunization therapy against periodontitis has not been studied extensively (37). Gingipains degrade cytokines (10,11), components of the complement system (8,9), and several receptors, including macrophage CD14 (13,14,38) and T-cells CD4 and CD8 (39), thereby perturbing the host defense system and facilitating sustained colonization of P. gingivalis.…”
Section: Discussionmentioning
confidence: 99%
“…Numerous approaches include the development of anticaries vaccines against either cell surface antigens (Abiko, 2000) or a glucosyltransferase enzyme that is responsible for glucan production (Xu et al, 2007). In an effort to reduce acid production of naturally occurring S. mutans, replacement therapy using a genetically engineered S. mutans that is able to outcompete indigenous strains while producing significantly less acid has been attempted (Hillman et al, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…This review will not survey this area of research in detail, and the reader should refer to several recent comprehensive reviews of this subject for a broader perspective (Abiko, 2000;Michalek et al, 2001). Despite the fact that anticaries vaccines have been demonstrated to be effective in animal models (Smith and Taubman, 1995), they have not yet been examined in human trials.…”
Section: (B) Vaccines Against Oral Diseasesmentioning
confidence: 99%