Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis

Maley, Matthew J.; Hunt, Andrew P.; Stewart, Ian B.; Faulkner, Simon; Minett, Geoffrey M.

doi:10.1371/journal.pone.0214223

Cited by 12 publications

(9 citation statements)

References 85 publications

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“…There is also evidence of the potentially deleterious effect of chronic heat exposure on carbohydrate metabolism, even in healthy subjects, one example being the recent study showing that carbohydrate metabolism was disrupted in this condition [29]. Since common glycoregulatory hormones and biomarkers do not explain the exaggerated increase in blood glucose in warm environmental temperature, it has been suggested that insulin resistance could develop in this condition [30].…”

Section: Discussionmentioning

confidence: 99%

Effect of warm environment on the skin blood flow response to food intake

Reminy

Hue

Antoine‐Jonville

2020

International Journal of Hyperthermia

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Background and objective: Warm exposure places high demands on thermoregulation mechanisms, which depend on the effectiveness of the microvascular function. The associations between the microcirculation and metabolism in warm environments have received little attention. The purpose of this study was to explore skin blood flow (SkBF) in response to food intake in a warm environment compared to control. Methods: Thirty-two healthy, acclimated-to-warm-environment and physically active participants were recruited (20 females and 12 males). They participated in two sessions (warm environment: 31 C and control: 20 C, presented in randomized order). SkBF was measured before and after standardized food intake through the acquisition of perfusion signals by laser Doppler flowmetry (Periflux System 5000), following a local heating protocol. Results: SkBF was affected by the environmental temperature, showing an increase in the warm environment compared to control (all p < .001). SkBF was significantly affected by food intake (all p < .007), being reduced after meals. In the men's group, SkBF was reduced in both environmental temperatures after meals. In women, meals affected SkBF at 20 C but not in the warm environment. Conclusion: These results may indicate a competition between thermo-and glyco-regulation in a warm environment to the detriment of glucose homeostasis in women.

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Section: Discussionmentioning

confidence: 99%

Effect of warm environment on the skin blood flow response to food intake

Reminy

Hue

Antoine‐Jonville

2020

International Journal of Hyperthermia

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“…Heat therapy has recently been targeted as a potential vehicle to evoke these positive thermal-induced adaptations in those precluded from undertaking exercise. Experimental investigations, large cohort surveys and reviews have expressed the potential for passive heating to improve physical and mental health in patients with cardiovascular disease (Brunt et al, 2016a,b;Maeda et al, 2018), diabetes (Kimball et al, 2018;Maley et al, 2019), peripheral arterial disease (Akerman et al, 2019), and depression (Janssen et al, 2016).…”

Section: Responses To Active (Exercise Heat Acclimation) and Passive mentioning

confidence: 99%

“…Recent research has shown positive therapeutic effects of passive heating for people with peripheral arterial disease (Neff et al, 2016;Akerman et al, 2019), chronic heart failure (Kihara et al, 2002;Ohori et al, 2012), diabetes (Hooper, 1999), and depression (Janssen et al, 2016). Passive heating also improves a range of health markers, including cardiovascular health indices, such as vascular function, blood pressure, and arterial stiffness (Brunt et al, 2016a,b), as well as metabolic health and glycemic control (Janssen et al, 2016;Kimball et al, 2018;Ely et al, 2019;Maley et al, 2019). Several mechanistic pathways may underpin these adaptations, including improved cellular respiration , circulating factors (Brunt et al, 2019), and vascular shear stress (Tinken et al, 2009;Thomas et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Could Heat Therapy Be an Effective Treatment for Alzheimer’s and Parkinson’s Diseases? A Narrative Review

et al. 2020

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Neurodegenerative diseases involve the progressive deterioration of structures within the central nervous system responsible for motor control, cognition, and autonomic function. Alzheimer's disease and Parkinson's disease are among the most common neurodegenerative disease and have an increasing prevalence over the age of 50. Central in the pathophysiology of these neurodegenerative diseases is the loss of protein homeostasis, resulting in misfolding and aggregation of damaged proteins. An element of the protein homeostasis network that prevents the dysregulation associated with neurodegeneration is the role of molecular chaperones. Heat shock proteins (HSPs) are chaperones that regulate the aggregation and disaggregation of proteins in intracellular and extracellular spaces, and evidence supports their protective effect against protein aggregation common to neurodegenerative diseases. Consequently, upregulation of HSPs, such as HSP70, may be a target for therapeutic intervention for protection against neurodegeneration. A novel therapeutic intervention to increase the expression of HSP may be found in heat therapy and/or heat acclimation. In healthy populations, these interventions have been shown to increase HSP expression. Elevated HSP may have central therapeutic effects, preventing or reducing the toxicity of protein aggregation, and/or peripherally by enhancing neuromuscular function. Broader physiological responses to heat therapy have also been identified and include improvements in muscle function, cerebral blood flow, and markers of metabolic health. These outcomes may also have a significant benefit for people with neurodegenerative disease. While there is limited research into body warming in patient populations, regular passive heating (sauna bathing) has been associated with a reduced risk of developing neurodegenerative disease. Therefore, the emerging evidence is compelling and warrants further investigation of the potential benefits of heat acclimation and passive heat therapy for sufferers of neurodegenerative diseases.

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“…Passively elevating body temperature, by means of sauna bathing or hot water immersion (HWI) for example, is increasingly recognised as a strategy to promote cardiometabolic health (Hoekstra et al, 2020). The acute effects of whole-body passive heating methods are well-characterised, with recent research interest focusing on metabolic, inflammatory and vascular markers (Maley et al, 2019;Cullen et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The effects of local versus systemic passive heating on the acute inflammatory, vascular and glycaemic response

Hoekstra

Ogawa

Santos

et al. 2021

Appl. Physiol. Nutr. Metab.

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The aim of this study was to compare the acute cardiometabolic and perceptual responses between local and whole-body passive heating. Using a water-perfused suit, ten recreationally active males underwent three 90 min conditions: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and exposure to a thermoneutral temperature (CON). Blood samples were collected before and up to 3h post-session to assess inflammatory markers, while a 2h oral glucose tolerance test was initiated 1h post-session. Femoral artery shear rate and perceptual responses were recorded at regular intervals. The interleukin (IL)-6 incremental area under the curve (iAUC) was higher for LBH (1096±851 pg/mL*270min) and WBH (833±476 pg/mL*270min) compared with CON (565±325 pg/mL*270min; p<0.047). Glucose concentrations were higher after WBH compared with LBH and CON (p<0.046). Femoral artery shear rate was higher at the end of WBH (1713±409 L/min) compared with LBH (943±349 L/min; p<0.001), and higher in LBH than CON (661±222 L/min; p=0.002). Affect and thermal comfort were more negative during WBH compared with LBH and CON (p<0.010). In conclusion, local passive heating elevated shear rate and the IL-6 iAUC. However, while resulting in more positive perceptual responses, the majority of the included cardiometabolic markers were attenuated compared with WBH. The increase in the interleukin-6 incremental area under the curve in response to passive heating is not reduced by upper-body cooling. Novelty: • Upper-body cooling attenuates the plasma nitrite, interleukin-1ra and femoral artery shear rate response to passive heating. • Upper-body cooling leads to more positive perceptual responses to passive heating.

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Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis

Cited by 12 publications

References 85 publications

Effect of warm environment on the skin blood flow response to food intake

Effect of warm environment on the skin blood flow response to food intake

Could Heat Therapy Be an Effective Treatment for Alzheimer’s and Parkinson’s Diseases? A Narrative Review

The effects of local versus systemic passive heating on the acute inflammatory, vascular and glycaemic response

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