Passive heat therapy for cerebral protection: new ideas of age‐old concepts

Coombs, Geoff B.; Tremblay, Joshua C.

doi:10.1113/jp277314

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…The mechanisms of I/R injury include changes in mitochondrial permeability, the disruption of ionic homeostasis, apoptosis-induced cell death, and necrosis [3][4][5][6]. Hypoxia-reoxygenation (H/R) is the in vitro model that is used to investigate the mechanism of I/R injury [1,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Sevoflurane Postconditioning Reduces Hypoxia-Reoxygenation Injury in H9C2 Embryonic Rat Cardiomyocytes and Targets the STRADA Gene by Upregulating microRNA-107

Jiang

2020

Med Sci Monit

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Departmental sources Background:Sevoflurane as a widely used inhalational general anesthetic that also has a cardioprotective role in hypoxiareoxygenation (H/R) injury. This study aimed to investigate the effects of microRNA-107 (miR-107) on sevoflurane postconditioning (SpostC) in H9C2 embryonic rat cardiomyocytes and to use bioinformatics analysis to identify the molecular basis of cardioprotection from sevoflurane in human cardiac tissue. Material/Methods:The STRADA gene was identified from the Gene Expression Omnibus (GEO) database. H9C2 embryonic rat cardiomyocytes were cultured with sevoflurane. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were used to measure the mRNA expression and protein expression of STRADA and miR-107 in H9C2 cells. TargetScanHuman version 7.2 was used to identify the target gene of miR-107 and to predict the STRADA 3'-UTR binding site of miR-107. The dual-luciferase reporter assay measured the relative luciferase activity. The cell proliferation rate and cell apoptosis were measured using the MTT assay and flow cytometry, respectively. Results:H/R injury in H9C2 cells following SpostC resulted in increased expression of miR-107 and reduced expression of STRADA. Specific binding of miR-107 was identified to STRADA 3'-UTR. Upregulation of the miR-107 in SpostC H/R injured H9C2 cells promoted cell proliferation, reduced cell apoptosis, and downregulating the protein expression of caspase-3. STRADA overexpression reduced the effects of a miR-107 mimic on SpostC. Conclusions:SpostC reduced H/R injury in H9C2 embryonic rat cardiomyocytes by targeting the STRADA gene and by upregulating the expression of microRNA-107.

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Section: Introductionmentioning

confidence: 99%

Sevoflurane Postconditioning Reduces Hypoxia-Reoxygenation Injury in H9C2 Embryonic Rat Cardiomyocytes and Targets the STRADA Gene by Upregulating microRNA-107

Jiang

2020

Med Sci Monit

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“…They may act as protective or pathogenic factors. In Alzheimer's disease, HSPs (especially HSP60, HSP70, and HSP90) inhibit amyloid aggregation and Aβ formation, and were proposed to negatively contribute to the process with increased extracellular expression (Campanella et al 2018;Coombs and Tremblay 2019). Different from the iHSP increase approach, reductions in eHSP72 levels with heat treatment were reported to be associated with reductions in fasting blood sugar and plasma insulin levels (Hoekstra et al 2018) and improvements in osteoarthritis symptoms (Ortega et al 2017).…”

Section: It Helps the Use Of Disease-specific Approaches In Connection With Heat Effectsmentioning

confidence: 99%

The importance of body core temperature evaluation in balneotherapy

Odabaşı

Turan

2021

Int J Biometeorol

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It is not wrong to say that there are no application standards or best practices in balneotherapy considering traditional applications. There is not enough information about how changes in body temperature, duration, and frequency of exposure to heat affect therapeutic outcomes of balneotherapeutic applications. Body core temperature (BCT) is probably the best parameter for expressing the heat load of the body and can be used to describe the causal relationship between heat exposure and its effects. There are several reasons to take BCT changes into account; for example, it can be used for individualized treatment planning, defining the consequences of thermal effects, developing disease-specific approaches, avoiding adverse effects, and designing clinical trials. The reasons why BCT changes should be considered instead of conventional measures will be discussed while explaining the effects of balneotherapy in this article, along with a discussion of BCT measurement in balneotherapy practice.

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“…Likewise, the beneficial effects of Waon therapy include reductions in blood pressure and cardiac‐related hospitalization for patients with chronic heart failure (Conceição et al., 2018; Ye et al., 2020). Narrative reviews, commentaries (Cheng & MacDonald, 2019; Coombs & Tremblay, 2019; Tipton, 2018) and primary investigations have reported broad beneficial effects among a range of health conditions, on leg vascular function (Engelland et al., 2019, 2020; Romero et al., 2017), skeletal muscle capillarization (Hesketh et al., 2019), glucose metabolism (Kimball et al., 2018; Leicht et al., 2019), insulin sensitivity (Hesketh et al., 2019), blood circulating factors (Brunt et al., 2018; Kojima et al., 2018) and cerebral function (Bailey et al., 2016; Coombs et al., 2019; Lee et al., 2014; Low et al., 2009). With ageing populations and the rising prevalence of CVD, there has been increased focus on the benefits of heat therapy for vascular function.…”

Section: Introductionmentioning

confidence: 99%

The effect of heat therapy on blood pressure and peripheral vascular function: A systematic review and meta‐analysis

Pizzey

Smith

Ruediger

et al. 2021

Experimental Physiology

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Lifelong sauna exposure is associated with reduced cardiovascular disease risk. Recent studies have investigated the effect of heat therapy on markers of cardiovascular health. We aimed to conduct a systematic review with meta-analysis to determine the effects of heat therapy on blood pressure and indices of vascular function in healthy and clinical populations. Four databases were searched up to September 2020 for studies investigating heat therapy on outcomes including blood pressure and vascular function. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was used to assess the certainty of evidence. A total of 4522 titles were screened, and 15 studies were included. Healthy and clinical populations were included. Heat exposure was for 30-90 min, over 10-36 sessions. Compared with control conditions, heat therapy reduced mean arterial pressure [n = 4 studies; mean

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Passive heat therapy for cerebral protection: new ideas of age‐old concepts

Cited by 8 publications

References 6 publications

Sevoflurane Postconditioning Reduces Hypoxia-Reoxygenation Injury in H9C2 Embryonic Rat Cardiomyocytes and Targets the STRADA Gene by Upregulating microRNA-107

Sevoflurane Postconditioning Reduces Hypoxia-Reoxygenation Injury in H9C2 Embryonic Rat Cardiomyocytes and Targets the STRADA Gene by Upregulating microRNA-107

The importance of body core temperature evaluation in balneotherapy

The effect of heat therapy on blood pressure and peripheral vascular function: A systematic review and meta‐analysis

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