Passive exposure to a contextual discriminative stimulus reinstates cocaine-seeking behavior in rats

Alleweireldt, Andrea T.; Weber, Suzanne M.; Neisewander, Janet L.

doi:10.1016/s0091-3057(01)00573-1

Cited by 55 publications

(46 citation statements)

References 19 publications

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“…Similarly, it has been shown that re-exposure to a drug-associated context is sufficient to reinstate drugseeking behavior in the response-contingent presence or absence (Rauhut et al, 2000;Alleweireldt et al, 2001) of a drug-paired explicit CS. However, the neural substrates that mediate context-induced reinstatement of drug seeking have not been identified.…”

Section: Intracranial Infusionsmentioning

confidence: 99%

“…Drug-associated environments, discrete conditioned stimuli (CSs, eg, paraphernalia), and exposure to cocaine elicit craving and relapse in drug users (Jaffe et al, 1989;Ehrman et al, 1992;Foltin and Haney, 2000). Similarly, cocaine-paired contextual stimuli (Rauhut et al, 2000;Alleweireldt et al, 2001;, explicit CSs (de Wit and Stewart, 1981), and cocaine priming injections (Gerber and Stretch, 1975) elicit cocaine-seeking behavior, an index of incentive motivation for cocaine in rats.…”

Section: Introductionmentioning

confidence: 99%

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The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats

Fuchs

Evans

Ledford

et al. 2004

Neuropsychopharmacol

485

517

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The present study tested the hypothesis that separate neural substrates mediate cocaine relapse elicited by drug-associated contextual stimuli vs explicit conditioned stimuli (CSs) and cocaine. Specifically, we investigated the involvement of the dorsal hippocampus (DH), basolateral amygdala (BLA), and dorsomedial prefrontal cortex (dmPFC) in contextual reinstatement of cocaine-seeking behavior and the involvement of the DH in explicit CS-and cocaine-induced reinstatement. Rats were trained to self-administer cocaine in a distinct context or in the presence of CSs paired explicitly with cocaine infusions. Responding of context-trained rats was then extinguished in the previously cocaine-paired or an alternate context, whereas responding of explicit CS-trained rats was extinguished in the absence of the CSs. Subsequently, the target brain regions or anatomical control regions were functionally inactivated using tetrodotoxin (0 or 5 ng/ side), and cocaine-seeking behavior (ie, nonreinforced responses) was assessed in the cocaine-paired context, in the alternate context, in the presence of the explicit CSs, or following cocaine priming (10 mg/kg, i.p.). DH inactivation abolished contextual, but failed to alter explicit CS-or cocaine-induced, reinstatement of cocaine-seeking behavior. BLA or dmPFC inactivation also abolished contextual reinstatement. Conversely, inactivation of the control brain regions failed to alter contextual reinstatement. In conclusion, the DH, BLA, and dmPFC play critical roles in contextual reinstatement. Previous findings suggest that the BLA is critical for explicit CS-induced, but not cocaine-primed, reinstatement and the dmPFC is critical for both explicit CS-induced and cocaine-primed reinstatement. Thus, distinct but partially overlapping neural substrates mediate context-induced, explicit CS-induced, and cocaine-primed reinstatement of extinguished cocaine-seeking behavior.

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Section: Intracranial Infusionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats

Fuchs

Evans

Ledford

et al. 2004

Neuropsychopharmacol

485

517

View full text Add to dashboard Cite

show abstract

“…Furthermore, midbrain dopamine neurons fire in response to conditioned stimuli predictive of reward as well as unfamiliar, but similar stimuli when presented in the same context (Schultz, 1998). The incentive motivational value of the context may be necessary to achieve heightened novel cue responding, perhaps through the training environment acting as discriminative stimuli or an 'occasion setter' (Alleweireldt et al, 2001;Swartzentruber, 1991). The importance of contextual contributions to novel cue reinstatement of drug-seeking behavior will require further attention.…”

Section: Contextual Effectsmentioning

confidence: 99%

Novel Cues Reinstate Cocaine-Seeking Behavior and Induce Fos Protein Expression as Effectively as Conditioned Cues

Bastle

Kufahl

Turk

et al. 2012

Neuropsychopharmacol

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Cue reinstatement of extinguished cocaine-seeking behavior is a widely used model of cue-elicited craving in abstinent human addicts. This study examined Fos protein expression in response to cocaine cues or to novel cues as a control for activation produced by test novelty. Rats were trained to self-administer cocaine paired with either a light or a tone cue, or received yoked saline and cue presentations, and then underwent daily extinction training. They were then tested for reinstatement of extinguished cocaine-seeking behavior elicited by response-contingent presentations of either the cocaine-paired cue or a novel cue (that is, tone for those trained with a light or vice versa). Surprisingly, conditioned and novel cues both reinstated responding and increased Fos similarly in most brain regions. Exceptions included the anterior cingulate, which was sensitive to test cue modality in saline controls and the dorsomedial caudate-putamen, where Fos was correlated with responding in the novel, but not conditioned, cue groups. In subsequent experiments, we observed a similar pattern of reinstatement in rats trained and tested for sucrose-seeking behavior, whereas rats trained and tested with the cues only reinstated to a novel, and not a familiar, light or tone. The results suggest that novel cues reinstate responding to a similar extent as conditioned cues regardless of whether animals have a reinforcement history with cocaine or sucrose, and that both types of cues activate similar brain circuits. Several explanations as to why converging processes may drive drug and novel cue reinforcement and seeking behavior are discussed.

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“…Bardo and Bevins 2000) and studies of cue-induced reinstatement of cocaine seeking behavior (Grimm and See 2000). Furthermore, several studies have demonstrated the ability of classically conditioned stimuli to subsequently control drug-seeking behavior following extinction of the operant response (Alleweireldt et al 2001;Kruzich et al 2001;Crombag and Shaham 2002). These examples indicate that classically conditioned (Pavlovian) cues can elicit drug-seeking behavior in animals.…”

mentioning

confidence: 99%

Conditioned Locomotion Is Not Correlated with Behavioral Sensitization to Cocaine An Intra-Laboratory Multi-Sample Analysis

Hotsenpiller

Wolf

2002

Neuropsychopharmacology

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Passive exposure to a contextual discriminative stimulus reinstates cocaine-seeking behavior in rats

Cited by 55 publications

References 19 publications

The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats

The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats

Novel Cues Reinstate Cocaine-Seeking Behavior and Induce Fos Protein Expression as Effectively as Conditioned Cues

Conditioned Locomotion Is Not Correlated with Behavioral Sensitization to Cocaine An Intra-Laboratory Multi-Sample Analysis

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