Passive epicardial containment prevents ventricular remodeling in heart failure

Chaudhry, Pervaiz A; Mishima, Takayuki; Sharov, Victor G.; Hawkins, James; Alferness, Clif A.; Paone, Gaetano; Sabbah, Hani N.

doi:10.1016/s0003-4975(00)01755-0

Cited by 125 publications

(77 citation statements)

References 17 publications

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“…One such device now being evaluated clinically is a cardiac wrapping device made from a bidirectional woven polyester that allows for shortening but resists circumferential expansion beyond the limits of the wrap. 454 Clinical trials in Europe 455 and the United States are currently under way to evaluate the safety and efficacy of this device in patients. Other ventricular constraint or support devices are also under investigation in Europe and the United States.…”

Section: Cardiac Support Devicesmentioning

confidence: 99%

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

Hunt¹,

Abraham²,

Chin³

et al. 2009

Circulation

1,926

765

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Section: Cardiac Support Devicesmentioning

confidence: 99%

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

Hunt¹,

Abraham²,

Chin³

et al. 2009

Circulation

1,926

765

View full text Add to dashboard Cite

“…One such device now being evaluated clinically is a cardiac wrapping device made from a bidirectional woven polyester that allows for shortening but resists circumferential expansion beyond the limits of the wrap (416). Clinical trials in Europe (417) and the United States are currently under way to evaluate the safety and efficacy of this device in patients.…”

Section: Drugs and Interventions Under Active Investigationmentioning

confidence: 99%

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult

Hunt

Abraham

Chin³

et al. 2005

Circulation

1,963

776

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“…Remodeling can result in increased ventricle size with dilated, thinned walls. Passive restraint devices and strategies to reduce ventricular size or increase wall thickness have been shown to attenuate or reverse adverse remodeling (45)(46)(47). Our device could potentially be turned off when no longer required, and clinicians could tailor the device as a passive restraint device, partial support, or full support.…”

Section: Discussionmentioning

confidence: 99%

Soft robotic sleeve supports heart function

et al. 2017

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(C.J.W); frank.pigula@ulp.org (F.A.P.) Overline: Cardiovascular diseaseOne Sentence Summary: A soft robotic sleeve modeled on the structure of the human heart assists cardiovascular function in an ex vivo and in vivo porcine model of heart failure. Abstract:There is much interest in form-fitting, low modulus, implantable devices or soft robots that can mimic or assist in complex biological functions such as the contraction of heart muscle. Here we present a soft robotic sleeve that is implanted around the heart and actively compresses and twists to act as a cardiac ventricular assist device. The sleeve does not contact blood, obviating the need for anticoagulation therapy or blood thinners, and reduces complications with current ventricular assist devices such as clotting and infection. Our approach used a biologically inspired design to orient individual contracting elements or actuators in a layered helical and circumferential fashion, mimicking the orientation of the outer two muscle layers of the mammalian heart. The resulting implantable soft robot mimicked the form and function of the native heart, with a stiffness value of the same order of magnitude as native heart tissue. We demonstrated feasibility of this soft sleeve device for supporting heart function in a porcine model of acute heart failure. The soft robotic sleeve can be customized to patient-specific needs and may have the potential to act as a bridge to transplant for patients with heart failure.

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Passive epicardial containment prevents ventricular remodeling in heart failure

Cited by 125 publications

References 17 publications

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult

Soft robotic sleeve supports heart function

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