Passive droplet sorting engendered by emulsion flow in constricted and parallel microchannels

Bhattacharjee, Debdeep; Chakraborty, Suman; Atta, Arnab

doi:10.1016/j.cep.2022.109126

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…After droplet generation, the droplets require further manipulation to realize chemical and biological reactions [ 97 , 98 ]. Droplet manipulation includes fission [ 99 , 100 ], fusion [ 101 ], mixing [ 102 ], sorting [ 103 , 104 , 105 ], and trapping [ 106 ]. Generally, droplet fission reduces the volume of the droplet and controls the chemical concentration encapsulated inside the droplet by producing a high-throughput droplet, whereas droplet fusion allows the introduction of new reagents into the droplet or the merging of droplets with different contents for further application [ 107 ].…”

Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.

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