Passive droplet control in microfluidic networks: A survey and new perspectives on their practical realization

Hamidović, Medina; Haselmayr, Werner; Grimmer, Andreas; Wille, Robert; Springer, Andreas

doi:10.1016/j.nancom.2018.10.002

Cited by 18 publications

(16 citation statements)

References 39 publications

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“…Although, we have shown first experimental results on individual components of microfluidic networks (e.g., droplet generation) the practical validation of a complete microfluidic networks is still missing and is part of our current research. Moreover, it would be interesting to further investigate the recently proposed healthcare applications for microfluidic networks, such as drug [28] and pathogen [25] screening. nichts anderes ergibt.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we have recently developed a DoD system that overcomes the aforementioned issues [22,23,[25][26][27]. A schematic of the proposed method is illustrated in Fig.…”

Section: Droplet-on-demandmentioning

confidence: 99%

“…For more details on the multi-droplet switch and on different network architectures please refer to the literature cited above. Moreover, a comprehensive survey on droplet-based microfluidic networks is given in[25,29,30].…”

mentioning

confidence: 99%

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Design and realization of flexible droplet-based lab-on-a-chip devices

Fink

Hamidović²,

Springer³

et al. 2020

Elektrotech. Inftech.

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This article provides an overview on the emerging field of droplet-based microfluidic networks. In such networks, droplets i.e., encapsulating biochemical samples can be adaptively transported via microchannels through different operations for particular experiments. This approach is particularly promising for the next generation of lab-on-a-chip devices, which should support more complex operations and more flexibility. We give an accessible introduction to droplet-based microfluidics and describe the principles, of microfluidic switches, which are the main components in microfluidic networks. Based on these principles we present the addressing schemes for microfluidic bus networks. Since the design of microfluidic networks is a rather complex task, which requires the consideration of a huge number of physical parameters, we introduce design automation methods and simulation tools. Finally, we present a method for the precise generation of individual droplets, which enables the practical realization of microfluidic networks. Moreover, we show the latest experimental results on droplet generation and switching. Keywords: droplet-based microfluidics; lab-on-a-chip; microfluidic networks Design und Realisierung von flexiblen tröpfchenbasierten Chiplaboren: Von der Theory zur Praxis. Dieser Artikel gibt einen Überblick über das Forschungsfeld der mikrofluidischen Netzwerke. In solchen Netzwerken werden Tröpfchen (die bspw. biochemische Proben enthalten) adaptiv durch verschiedene Prozessstufen über Mikrometer-dünne Kanäle transportiert, um bestimmte Untersuchungen durchzuführen. Dieser neue Ansatz ist vor allem für die nächste Generation an Chiplaboren (engl. lab-on-a-chip) sehr vielversprechend, welche komplexere Operationen und mehr Flexibilität unterstützen sollen. Wir besprechen die Grundlagen tröpfchenbasierter Mikrofluidik und beschreiben die Prinzipien mikrofluidischer Schalter (engl. switch), welche die Hauptkomponenten in mikrofluidischen Netzwerken darstellen. Basierend auf diesen Prinzipien stellen wird die Adressierungsschemas in mikrofluidischen Busnetzwerken vor. Da der Entwurf von mikrofluidischen Netzwerken eine komplexe Aufgabe ist, bei der eine große Anzahl von physikalischen Parametern berücksichtigt werden muss, stellen wir verschiedene Ansätze zur Entwurfsautomatisierung und Simulation vor. Schließlich präsentieren wir eine Methode zur präzisen Erzeugung von Tröpfchen, die eine praktische Realisierung von mikrofluidischen Netzwerken ermöglichen soll. Weiters zeigen wir die neuesten experimentellen Ergebnisse zur Tröpfchengenerierung bzw. zur Realisierung von Schaltern.

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Section: Discussionmentioning

confidence: 99%

“…Thus, we have recently developed a DoD system that overcomes the aforementioned issues [22,23,[25][26][27]. A schematic of the proposed method is illustrated in Fig.…”

Section: Droplet-on-demandmentioning

confidence: 99%

See 1 more Smart Citation

Design and realization of flexible droplet-based lab-on-a-chip devices

Fink

Hamidović²,

Springer³

et al. 2020

Elektrotech. Inftech.

Self Cite

View full text Add to dashboard Cite

show abstract

“…For a precise control over droplet formation in DoD systems (our third requirement) the breakup should be in the squeezing regime. 36 The pressure balance between the dispersed and continuous phase interface at the junction dominates the droplet formation in the squeezing regime.…”

Section: Droplet Generatormentioning

confidence: 99%

“…without any on chip active elements such as valves) DoD is used, and even less in combination with a T-junction geometry. Vanapalli et al, 37 and in a similar setup Hamidović et al, 36 used simple pressure actuation to form a single water droplet in oil in a T-junction. In this case, the oil phase was driven by hydrostatic heads.…”

Section: Droplet Generatormentioning

confidence: 99%

Droplet encapsulation of electrokinetically-focused analytes without loss of resolution

et al. 2020

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Recent Progress of Droplet Microfluidic Emulsification Based Synthesis of Functional Microparticles

et al. 2023

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The remarkable control function over the functional material formation process enabled by droplet microfluidic emulsification approaches can lead to the efficient and one‐step encapsulation of active substances in microparticles, with the microparticle characteristics well regulated. In comparison to the conventional fabrication methods, droplet microfluidic technology can not only construct microparticles with various shapes, but also provide excellent templates, which enrich and expand the application fields of microparticles. For instance, intersection with disciplines in pharmacy, life sciences, and others, modifying the structure of microspheres and appending functional materials can be completed in the preparation of microparticles. The as‐prepared polymer particles have great potential in a wide range of applications for chemical analysis, heavy metal adsorption, and detection. This review systematically introduces the devices and basic principles of particle preparation using droplet microfluidic technology and discusses the research of functional microparticle formation with high monodispersity, involving a plethora of types including spherical, nonspherical, and Janus type, as well as core–shell, hole–shell, and controllable multicompartment particles. Moreover, this review paper also exhibits a critical analysis of the current status and existing challenges, and outlook of the future development in the emerging fields has been discussed.

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Passive droplet control in microfluidic networks: A survey and new perspectives on their practical realization

Cited by 18 publications

References 39 publications

Design and realization of flexible droplet-based lab-on-a-chip devices

Design and realization of flexible droplet-based lab-on-a-chip devices

Droplet encapsulation of electrokinetically-focused analytes without loss of resolution

Recent Progress of Droplet Microfluidic Emulsification Based Synthesis of Functional Microparticles

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