Passive Commuting and Higher Sedentary Time Is Associated with Vitamin D Deficiency in Adult and Older Women: Results from Chilean National Health Survey 2016–2017

Solis‐Urra, Patricio; Cristi-Montero, Carlos; Romero-Parra, Javier; Zavala-Crichton, Juan Pablo; Sáez-Lara, María José; Plaza‐Díaz, Julio

doi:10.3390/nu11020300

Cited by 23 publications

(16 citation statements)

References 66 publications

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“…In the Southern Hemisphere, Chile and Argentina have significant portions of the country residing above 37 o . Both have vitamin D supply estimates from natural food sources in the range of 3.1 to 5.5 µg/day, and reported prevalence of vitamin D deficiency of 14-26% overall and higher in the Southern regions of the country (higher latitudes) [41,42]. These Northern and Southern Hemisphere countries residing at >37 o broadly track to upper middle to high income settings and as such have relatively good supply of foods of animal origin, key providers of vitamin D in the food chain.…”

Section: Discussionmentioning

confidence: 99%

Global View of Per Capita Daily Vitamin D Supply Estimates as Proxy Measures for Vitamin D Intake Data

Cashman

2021

JBMR Plus

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Nationally representative data on vitamin D intake can inform on the adequacy of dietary supply of vitamin D in a population, but such data is lacking for a majority of countries.Estimates of average per capita supply of vitamin D, as calculated using information from the Food and Agriculture Organisation (FAO) national food balance sheets (FBS) can be used as proxy measures for vitamin D intake within a population. In the present work, FAO national FBS (from 2004 to 2017) for 173-178 countries around the globe were used to generate such average per capita vitamin D supply estimates. For countries where food fortification with vitamin D was common, the estimates accounted for this. Using the 2004-2013 FBS data, there was a large range in average per capita vitamin D supply ranging from 0.3 (Ethiopia) to 17.8 (Maldives) µg/day. Globally, 40, 60, 70, 4 , 2 and 2 countries had average per capita vitamin D supply estimates <1.

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Section: Discussionmentioning

confidence: 99%

Global View of Per Capita Daily Vitamin D Supply Estimates as Proxy Measures for Vitamin D Intake Data

Cashman

2021

JBMR Plus

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“…Higher triglycerides as a metabolite class were significantly inversely associated with XFG, which is in contrast to findings from multiple cross-sectional studies that observed positive associations with XFG. [64][65][66][67][68] Although we adjusted for caffeine intake and recreational physical activity, lower triglycerides in cases may be capturing residual information about greater coffee consumption 69 or lower sedentary behavior and greater physical activity, 70,71 which are likely associated with higher homocysteine levels and greater UV exposure, 72 respectively, and higher XFG risk. Also, as higher triglyceride levels are a component of metabolic syndrome, it could also be a proxy for greater hyperglycemia, which may have protective effects against the accumulation of XFM.…”

Section: Lysophosphatidylcholines (Lpcs)mentioning

confidence: 99%

Pre-diagnostic plasma metabolomics and the risk of exfoliation glaucoma

Kang

Zeleznik

Frueh

et al. 2021

Preprint

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Objective: To identify pre-diagnostic plasma metabolomic biomarkers associated with risk of exfoliation glaucoma (XFG). Methods: We conducted a metabolomic study using a 1:1 matched nested case-control study design within the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS). Participants provided blood samples in 1989-'90 (NHS) and 1993-'95 (HPFS); we identified 205 participants who newly developed XFG during follow-up to 2018 (average time to diagnosis from blood draw=11.8 years); XFG was confirmed with medical record review. We profiled plasma metabolites using liquid chromatography-mass spectrometry and identified 379 known metabolites that passed quality control checks. Metabolites were transformed using probit scores for normality. We used multivariable-adjusted logistic regression adjusting for matching factors (such as age, residential latitude, season and time of blood draw), glaucoma family history and other covariates. Metabolite Set Enrichment Analysis was used to identify metabolite classes associated with risk of XFG. Number of effective tests (NEF) and False Discovery Rate (FDR) were used to adjust for multiple comparisons. Results: Mean age of cases (n=205) at diagnosis was 71 years; 84% were women and >99% were Caucasian; matched controls (n=205) all reported eye exams as of the matched cases' index date. A total of 33 metabolites were nominally significantly associated with XFG risk (p<0.05) and 4 metabolite classes were significantly associated (FDR<0.05). Overall, adverse associations were observed for the classes of lysophosphatidylcholines (FDR=0.02) and phosphatidylethanolamine plasmalogens (FDR=0.004). Inverse associations were observed for triglycerides (FDR<0.001) and steroid and steroid derivatives (FDR=0.03); in particular, the multivariable-adjusted odds ratio for XFG risk associated with each 1 standard deviation increase in plasma cortisone levels was 0.49 (95% CI=0.32-0.74; NEF=0.05). Results did not differ materially by time between blood draw and diagnosis, latitude of residence (< or ≥41°N latitude), age (< or ≥60 years), sex or glaucoma family history. Conclusions: Four broad classes of metabolites (including steroids such as cortisone and 3 lipid classes) in pre-diagnostic plasma collected almost a decade before diagnosis were associated with XFG risk; these results should be confirmed in future studies.

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“…The question was, "How much time do you usually spend sitting or reclining on a typical day (hours and minutes per day)?" Based on previous studies [25], the high (≥240 min/day) or low levels of ST (<240 min/day) were identified.…”

Section: Classification Of Physical Activity and Sedentary Timementioning

confidence: 99%

Cardiorespiratory Fitness, Physical Activity, Sedentary Time and Its Association with the Atherogenic Index of Plasma in Chilean Adults: Influence of the Waist Circumference to Height Ratio

et al. 2020

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Atherogenic index of plasma (AIP) is a novel biomarker related to cardiovascular disease (CVD). Cardiorespiratory fitness (CRF) and physical activity (PA) have an inverse relationship with the AIP, while sedentary time (ST) and fatness present a positive association. This study aimed to determine the combined and independent association of CRF, PA, and ST with the AIP, and additionally to establish the waist-to-height ratio (WHtR) mediation role. Data from the Chilean national health survey were used (4671 adults). A PACS (Physical Activity Cardiorespiratory Sedentary) score was created ranging from 0 to 3, indicating the number of positive recommendations met (PA, ST, and CRF). AIP was calculated (Log10 triglycerides/high-density lipoprotein-cholesterol). The combined analysis showed that compared to those with a PACS score of 0, those with a score of 1 or 2 did not present significantly reduced AIP values (adjusted by the WHtR); however, those with a score of 3 did (OR (odds ratio) = 0.50; 95% CI, 0.32 to 0.77; p < 0.001). Independent analysis showed that CRF seems to be the only variable that supports the combined result (β = −0.212; p < 0.001). Finally, the mediation analysis indicated that the WHtR mediated the association between CRF and the AIP in 34.2% of cases. Overall, only CRF had a significant and inverse association with the AIP. Nonetheless, around one-third of this beneficial relationship is affected by an elevated WHtR.

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Passive Commuting and Higher Sedentary Time Is Associated with Vitamin D Deficiency in Adult and Older Women: Results from Chilean National Health Survey 2016–2017

Cited by 23 publications

References 66 publications

Global View of Per Capita Daily Vitamin D Supply Estimates as Proxy Measures for Vitamin D Intake Data

Global View of Per Capita Daily Vitamin D Supply Estimates as Proxy Measures for Vitamin D Intake Data

Pre-diagnostic plasma metabolomics and the risk of exfoliation glaucoma

Cardiorespiratory Fitness, Physical Activity, Sedentary Time and Its Association with the Atherogenic Index of Plasma in Chilean Adults: Influence of the Waist Circumference to Height Ratio

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