Passive Coagulability Assay Based on Coherence-Gated Light Scattering

Abstract

Coagulation monitoring relies on in vitro tests where the clot formation is induced using external stimuli. We report an optical method capable of revealing the propensity of coagulation based solely on the natural dynamics of erythrocytes in whole blood. In contrast to traditional techniques, our approach provides means to assess the blood coagulability without the need to chemically trigger the coagulation. Results of correlations with standard clinical methods suggest that this optical assay could be used for continuous management of blood coagulation during clinical procedures.

Passive high-frequency microrheology of blood

“…By taking advantage of an intrapatient normalization i.e., normalization of a patient's response to their own initial conditions, one can implement differential analysis that permits a more proper inter-patient comparison. 56,59 A complete inter-patient analysis will be the subject of a future report.…”