Passive and Active Anti-Hepatitis B Immunization of Children with Hematological Malignancies

Seroprevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections in children with cancer at diagnosis and following therapy in Turkey

“…As antineoplastic therapy intensity increases, the antibody response to chemotherapy decreases. In patients receiving such intensive treatment, the use of hepatitis B immunglobulin with or without hepatitis B vaccine may be considered [14,15].…”

Recombinant alpha-2a interferon treatment in a child with T-cell leukemia and chronic hepatitis B

“…Children receiving anticancer therapy have a substantially weaker response to hepatitis B vaccine, reflecting the profound immunosupression during chemotherapy [4,12]. About one third to two thirds of these patients achieve a protective concentration of anti-HBs [2,4,12]. After chronic HBV infection was documented in our patient, we started a-IFN treatment, since a-IFN can be used in the treatment of chronic HBV infection [16,23,27,28].…”

“…Even though he was vaccinated three times for hepatitis B, he did not acquire immunization because of immunosuppression. Children receiving anticancer therapy have a substantially weaker response to hepatitis B vaccine, reflecting the profound immunosupression during chemotherapy [4,12]. About one third to two thirds of these patients achieve a protective concentration of anti-HBs [2,4,12].…”