Passive acoustic emission monitoring of pellet coat thickness in a fluidized bed

Sheahan, Taylor; Briens, Lauren

doi:10.1016/j.powtec.2015.08.005

Cited by 11 publications

(2 citation statements)

References 30 publications

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“…Pellets prepared by liquid layer technology are also successful in improving bioavailability according to previous studies. Pellets greatly increases the interaction surface between drugs and the stomach or intestine compared with conventional tablets [17,18]. While selecting and optimizing the accessories as well as technological parameters, we acquired three GB formulations, named HME08, LL06 and conventional tablets, respectively.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs

et al. 2015

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Ginkgolide B (GB), an important active constituent of Ginkgo biloba extract, has been used in clinical applications for the treatment of dementia, cerebral insufficiency or related cognitive decline. To investigate the main pharmacokinetic characteristics of three different GB formulations in beagle dogs, a simple, specific and sensitive LC-MS/MS method was established and validated. The separation of the analytes was achieved on an Agilent Eclipse Plus C18 column (1.8 μm, 2.1 × 50 mm) with a mobile phase consisting of water and acetonitrile. The flow rate was set at 0.4 mL/min. Quantitation was performed using multiple reaction monitoring (MRM) in negative ion mode, with the transitions at m/z (Q1/Q3) 423.1/367.1 for GB and m/z 269.3/170.0 for IS. The linear calibration curve of GB was obtained over the concentration range of 2-200 ng/mL. The intra-and inter-day precisions were <15% and the accuracies were within ±12.7%. The validated method was applied to compare the pharmacokinetic characteristics of GB in healthy beagle dogs after oral administration of three formulations (HME08, GB capsule prepared by hot-melt extrusion technology; LL06, GB pellet prepared by liquid layer technology; conventional GB tablet). The Cmax values of GB from different formulations in beagle dog plasma were 309.2, 192.4 and 66.6 μg/L, and the AUC values were 606.7, 419.1 and 236.2 μg/L•h, respectively. The data suggested that the exposure level of GB from HME08 and LL06 in beagle dog plasma was greatly improved compared with conventional tablets. This study should be helpful for the design and development of oral GB preparations.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs

et al. 2015

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“…Acoustic emission (AE) is one of the most effective and efficient techniques which can be used for monitoring and detecting fracture and fatigue in metals, wood, ceramics, fibreglass, composites, plastics and concretes [1]. AE detection uses the energy released from the defected structure during its failure and no external energy source is involved, and hence is considered as a passive technology [2,3]. Accordingly, movements within a material can be detected by AE, whilst other techniques have limited detection of geometrical distortions, and hence AE technique has superior capabilities compared to these methods [2].…”

Section: Introductionmentioning

confidence: 99%

Experimental Investigation Using Acoustic Emission Technique for Quasi-Static Cracks in Steel Pipes Assessment

et al. 2021

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Acoustic emission (AE) is a phenomenon where transient waves of stress are generated during deformed material, which is applied to detect and monitor the cracks and cracks propagation. The majority of related literature studied simulated wave sources, which were utilized for a single point of a pipe and have been strictly controlled by temporal characteristics. Therefore, the realistic wave sources which do not have known temporal characteristics are studied in the present work. The realistic source is quasi-static crack propagation under three-point bending. The distortions of AE signals are experimentally evaluated by testing the AE signals of crack propagation using simulated sources. A variety of stress intensities are applied on a steel pipe to determine the effect of stress type and intensity on the characteristics of the source using time and frequency domains. Machines are mounted on the steel pipe to locate and reconstitute the features of time and frequency domain of the AE sources. It is concluded that the AE energy was sensitive to the crack size which was concerning to the transition of plane-stress to plane-strain. The potential of AE technique for identifying the nature, intensity and location of crack propagation is demonstrated.

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Production and investigation of sustained berberine pellet drug release system

Gao

Xia

Sun

et al. 2018

Advanced Powder Technology

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Passive acoustic emission monitoring of pellet coat thickness in a fluidized bed

Cited by 11 publications

References 30 publications

Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs

Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs

Experimental Investigation Using Acoustic Emission Technique for Quasi-Static Cracks in Steel Pipes Assessment

Production and investigation of sustained berberine pellet drug release system

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