Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models

Morrone, Maurílio da Silva; Assis, Adriano Martimbianco de; Rocha, Ricardo Fagundes da; Gasparotto, Juciano; Gazola, Andressa Córneo; Costa, Geison Modesti; Zucolotto, Silvana Maria; Castellanos, Leonardo; Ramos, Freddy A.; Schenkel, Eloir Paulo; Reginatto, Flávio Henrique; Gelain, Daniel Pens; Moreira, José Cláudio Fonseca

doi:10.1016/j.fct.2013.07.028

Cited by 43 publications

(13 citation statements)

References 43 publications

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“…Here, we added the information to contribute with the concept that carotenoids and polyphenols also collaborate with the antioxidant potential of peaches. The ability of plants to scavenge ROS seems to be related to the chemical structure of phenolic compounds [64,65]. Our findings suggest that the Peel, FPP and PPP may present some important antioxidant properties, probably related to their carotenoids and phenolic content.…”

Section: Discussionmentioning

confidence: 70%

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

Gasparotto

Somensi

Bortolin

et al. 2014

The Journal of Nutritional Biochemistry

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The present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)κB-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-α, IL-1β, RAGE and NFκB. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup - which was the least enriched in antioxidants - displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate dehydrogenase leakage into serum and maintenance of organ architecture. Therefore, the herein presented results show evidence that supplementation with peach products may be protective against organ damage caused by oxidative stress, being interesting candidates for production of antioxidant-enriched functional foods.

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Section: Discussionmentioning

confidence: 70%

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

Gasparotto

Somensi

Bortolin

et al. 2014

The Journal of Nutritional Biochemistry

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“…This ex vivo model retains most of the original histological structure of the organ and hence preserves its physiological characteristics. ( 10 , 27 )…”

Section: Resultsmentioning

confidence: 99%

Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo

Gasparotto

Somensi

Bortolin

et al. 2014

J. Clin. Biochem. Nutr.

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Antioxidant, anti-glycation and anti-inflammatory activities of fresh and conserved peach fruits (Prunus persica L. Batsch) were compared. Fresh peach pulps, peels, preserve peach pulps and the preserve syrup were prepared at equal concentrations. Rat liver, kidney and brain cortex tissue slices were pre-incubated with peach samples, subjected to oxidative stress with FeSO4 and hydrogen peroxide. Fresh peach pulps and peel conferred higher protection against cytotoxicity and oxidative stress than preserve peach pulps in most tissues. Release of tumor necrosis factor-α and interleukin-1β was also significantly decreased by Fresh peach pulps and peel, followed by preserve peach pulps. Total phenolic determination and HPLC analysis of carotenoids showed that the content of secondary metabolites in Fresh peach pulps and peel is significantly higher than in preserve peach pulps, while the syrup had only small or trace amounts of these compounds. Fresh peach pulps and Peel demonstrated high antioxidant and anti-inflammatory effects preventing against induced damage.

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“…Removal of ROS is achieved with several antioxidative enzymes including the three primary endogenous enzymes: CAT, GSH-Px, and SOD [27]. Although antioxidant systems can help protect the body against free radicals, they might become overwhelmed during periods of chronic oxidative stresses [28].…”

Section: Effect Of Mcg On Cellular Antioxidant Enzymes and Non-enzymamentioning

confidence: 99%

Neuroprotective effects of macranthoin G from Eucommia ulmoides against hydrogen peroxide-induced apoptosis in PC12 cells via inhibiting NF-κB activation

Wang

et al. 2014

Chemico-Biological Interactions

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Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models

Cited by 43 publications

References 43 publications

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo

Neuroprotective effects of macranthoin G from Eucommia ulmoides against hydrogen peroxide-induced apoptosis in PC12 cells via inhibiting NF-κB activation

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