PASSflow-Synthesen mit funktionalisierten monolithischen Polymer/Glas-Kompositen in Mikroreaktoren

Kirschning, Andreas; Altwicker, Carsten; Dräger, Gerald; Harders, Jan; Hoffmann, Nora; Hoffmann, Ulrich; Schönfeld, Hagen; Solodenko, Wladimir; Kunz, Ulrich

doi:10.1002/1521-3757(20011105)113:21<4118::aid-ange4118>3.0.co;2-h

Cited by 54 publications

(45 citation statements)

References 13 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To circumvent the handling problems associated with beads, a so-called pass-flow system has recently been developed by Kirschning et al [225] Here the beads are immobilized on a porous glass fritt sealed in a pressure tubing. However, most of the employed scavengers have relatively small loading capacities and hence this approach is useful only for small-scale reactions.…”

Section: Polymer-supported Scavenger Reagentsmentioning

confidence: 99%

Modern Separation Techniques for the Efficient Workup in Organic Synthesis

Tzschucke

Märkert

Bannwarth

et al. 2002

Angew. Chem. Int. Ed.

339

133

View full text Add to dashboard Cite

The shift of paradigm in combinatorial chemistry, from large compound libraries (of mixtures) on a small scale towards defined compound libraries where each compound is prepared in an individual well, has stimulated the search for alternative separation approaches. The key to a rapid and efficient synthesis is not only the parallel arrangement of reactions, but simple work-up procedures so as to circumvent time-consuming and laborious purification steps. During the initial development stages of combinatorial synthesis it was believed that rational synthesis of individual compounds could only be achieved by solid-phase strategies. However, there are a number of problems in solid-phase chemistry: most notably there is the need for a suitable linker unit, the limitation of the reaction conditions to certain solvents and reagents, and the heterogeneous reaction conditions. Further disadvantages are: the moderate loading capacities of the polymeric support and the limited stability of the solid support. In the last few years several new separation techniques have been developed. Depending on the chemical problem or the class of compounds to be prepared, one can choose from a whole array of different approaches. Most of these modern separation approaches rely on solution-phase chemistry, even though some of them use solid-phase resins as tools (for example, as scavengers). Several of these separation techniques are based on liquid-liquid phase separation, including ionic liquids, fluorous phases, and supercritical solvents. Besides being benign with respect to their environmental aspects, they also show a number of advantages with respect to the work-up procedures of organic reactions as well as simplicity in the isolation of products. Another set of separation strategies involves polymeric supports (for example, as scavengers or for cyclative cleavage), either as solid phases or as soluble polymeric supports. In contrast to solid-phase resins, soluble polymeric supports allow reactions to be performed under homogeneous conditions, which can be an important factor in catalysis. At the same time, a whole set of techniques has been developed for the separation of these soluble polymeric supports from small target molecules. Finally, miscellaneous separation techniques, such as phase-switchable tags for precipitation by chemical modification or magnetic beads, can accelerate the separation of compounds in a parallel format.

show abstract

Section: Polymer-supported Scavenger Reagentsmentioning

confidence: 99%

Modern Separation Techniques for the Efficient Workup in Organic Synthesis

Tzschucke

Märkert

Bannwarth

et al. 2002

Angew. Chem. Int. Ed.

339

133

View full text Add to dashboard Cite

show abstract

“…Polymer‐based monolithic supports first received great attention with regards to catalytic applications in fine‐chemicals synthesis 1h. 4 However, the possible swelling of these polymeric materials may cause pressure drops along the microchannel resulting in variations in the residence time for pressure‐driven microreactors 1c.…”

Section: Methodsmentioning

confidence: 99%

Functionalized Inorganic Monolithic Microreactors for High Productivity in Fine Chemicals Catalytic Synthesis

et al. 2009

View full text Add to dashboard Cite

show abstract

“…For instance, widely used Merrifield resins consist in an insoluble polystyrene polymer cross-linked with divinylbenzene units, typically swelled in DMF or in CH 2 Cl 2 , both solvents are of major concern in the Green Chemistry arena. In addition, our final goal is to employ heterogeneous catalysts in flow reactors and a major issue that limits this application is the swelling properties of the resins that leads to a significant increase of their volume when treated with the proper solvent therefore requiring to operate a very high pressure [64].…”

Section: Heterogeneous Catalysis In Greener Mediamentioning

confidence: 99%

Definition of green synthetic tools based on safer reaction media, heterogeneous catalysis, and flow technology

Vaccaro

Curini

Ferlin

et al. 2017

Pure and Applied Chemistry

View full text Add to dashboard Cite

Green/Sustainable Chemistry is the scientific platform where chemists are contributing from different areas to develop modern and efficient processes aimed at minimizing the environmental impact of chemical production. To reach these goals scientists, from both academia and industry, need to strongly focus their fundamental and innovative research towards the application of modern principles of Green Chemistry. In this contribution a description of our efforts in this direction is presented.

show abstract

PASSflow-Synthesen mit funktionalisierten monolithischen Polymer/Glas-Kompositen in Mikroreaktoren

Cited by 54 publications

References 13 publications

Modern Separation Techniques for the Efficient Workup in Organic Synthesis

Modern Separation Techniques for the Efficient Workup in Organic Synthesis

Functionalized Inorganic Monolithic Microreactors for High Productivity in Fine Chemicals Catalytic Synthesis

Definition of green synthetic tools based on safer reaction media, heterogeneous catalysis, and flow technology

Contact Info

Product

Resources

About