Passenger donor lymphocytes: To affinity and beyond

Manook, Miriam; Motallebzadeh, Reza; Pettigrew, Gavin J.

doi:10.1126/scitranslmed.add2145

Cited by 1 publication

(1 citation statement)

References 8 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, the activation of donor-derived T cells is a feature of a graft vs. host response; however, the cytokines produced by the activated T cells contribute to the class switch and expansion of the host vs. graft B cell response (in this case, recipient B cells act as antigen-presenting cells of the recently described inverted direct pathway). Although this mechanism has been elegantly demonstrated in a mouse model and there are indications that it is acting on human solid organ transplantation, its relative importance still needs to be proven [28]. There is evidence that this could be an important source of DSA in clinical ITx since a correlation between the amount of passenger donor-derived T cells in the graft and the kinetics of the appearance of DSA in different types of transplants [27].…”

Section: A New Pathway Of Allogenic Immune Activation Operating In Itxmentioning

confidence: 99%

Intestinal Transplant Immunology and Intestinal Graft Rejection: From Basic Mechanisms to Potential Biomarkers

Rumbo

Oltean

2023

IJMS

View full text Add to dashboard Cite

Intestinal transplantation (ITx) remains a lifesaving option for patients suffering from irreversible intestinal failure and complications from total parenteral nutrition. Since its inception, it became obvious that intestinal grafts are highly immunogenic, due to their high lymphoid load, the abundance in epithelial cells and constant exposure to external antigens and microbiota. This combination of factors and several redundant effector pathways makes ITx immunobiology unique. To this complex immunologic situation, which leads to the highest rate of rejection among solid organs (>40%), there is added the lack of reliable non-invasive biomarkers, which would allow for frequent, convenient and reliable rejection surveillance. Numerous assays, of which several were previously used in inflammatory bowel disease, have been tested after ITx, but none have shown sufficient sensibility and/or specificity to be used alone for diagnosing acute rejection. Herein, we review and integrate the mechanistic aspects of graft rejection with the current knowledge of ITx immunobiology and summarize the quest for a noninvasive biomarker of rejection.

show abstract

Section: A New Pathway Of Allogenic Immune Activation Operating In Itxmentioning

confidence: 99%

Intestinal Transplant Immunology and Intestinal Graft Rejection: From Basic Mechanisms to Potential Biomarkers

Rumbo

Oltean

2023

IJMS

View full text Add to dashboard Cite

show abstract

Passenger donor lymphocytes: To affinity and beyond

Abstract: Graft-versus-host recognition by passenger donor lymphocytes within organ transplants can trigger host alloantibody production (Charmetant et al .) .

Cited by 1 publication

References 8 publications

Intestinal Transplant Immunology and Intestinal Graft Rejection: From Basic Mechanisms to Potential Biomarkers

Intestinal Transplant Immunology and Intestinal Graft Rejection: From Basic Mechanisms to Potential Biomarkers

Contact Info

Product

Resources

About