Passage of carbohydrate into the colon

Stephen, Alison M.; Haddad, Anne C.; Phillips, Sidney F.

doi:10.1016/0016-5085(83)90012-4

Cited by 296 publications

(84 citation statements)

References 20 publications

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“…Proteins are the precursors for sulphurous, indolic and phenolic compounds and volatile fatty acids (Mackie et al, 1998). Non-starch polysaccharides (NSP) and resistant starch (RS) can enter the large intestine and are available for fermentation by microbiota (Cummings and Macfarlane, 1991;Cummings and Englyst, 1993;Stephen et al, 1983). Fermentable carbohydrates may modulate odour potential.…”

Section: Introductionmentioning

confidence: 99%

Interactive effects of dietary crude protein and fermentable carbohydrate levels on odour from pig manure

Aarnink

Jongbloed

et al. 2008

Livestock Science

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Section: Introductionmentioning

confidence: 99%

Interactive effects of dietary crude protein and fermentable carbohydrate levels on odour from pig manure

Aarnink

Jongbloed

et al. 2008

Livestock Science

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“…Cellulose, like other dietary fibers, is not absorbed in the small intestine and passes through to the colon where it can be fermented. Recent studies (11)(12)(13) suggest that some starch may also escape digestion in the small bowel. The carbohydrate reaching the colon could dilute the fat; or possibly, the fermentation of starch and cellulose in the colon could lead to a lower pH in the fecal stream and thus a reduction in the concentration of the toxic free bile and fatty acids (8).…”

Section: Discussionmentioning

confidence: 98%

Dietary factors affecting the proliferation of epithelial cells in the mouse colon

Caderni

1988

Nutrition and Cancer

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Corn oil (CO), given as a bolus to female C57BL/6J mice, caused a marked increase in cell proliferation in the colon; this was assessed with a two-hour colchicine arrest for mitotic figures (MF) and with [3H]thymidine incorporation for labeled cells (LC) per crypt measured in histological preparations. In contrast, the same amount of fat given as a bolus in a high-fat diet mixture failed to increase cell proliferation. To determine whether a particular component in the diet was responsible for this protective effect, mice were treated with boluses of CO (0.4 ml) mixed with cellulose (CL), starch (ST), sucrose (SU), casein (CS), vitamin mix (VM) or mineral mix (MM). The results indicated that cellulose, starch, and minerals reduced the proliferative activity caused by CO (MF/crypt CO = 1.30 +/- 0.24; CO + CL = 0.55 +/- 0.10, CO + ST = 0.91 +/- 0.23, CO + MM = 0.63 +/- 0.16), whereas sucrose, casein, and vitamin mix did not. To test the implications of these findings in chronic feeding studies, groups of animals were fed (for 4 wks) diets "deficient" in starch and cellulose, calcium, and both the complex carbohydrates and calcium. The results showed that both calcium and complex carbohydrates affected the proliferation rate significantly (for instance, MF/crypt = 1.44 +/- 0.22 for both factors deficient vs. 0.48 +/- 0.05 for both factors present). We concluded that starch, cellulose, and calcium are protective for the toxic effect of CO on the mouse colon.

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“…Many studies have been undertaken which demonstrate that not only fiber but also starch enters the colon (2)(3)(4)(5)(6)(7)(8). Our own studies of ileostomates suggested that the presence of fiber in starchy foods increased the losses of starch to the colon (3), thereby maximizing the fermentation which might result from consumption of starchy foods.…”

Section: 'Traditional Diets' Substrate Availability and Fermentationmentioning

confidence: 94%

Metabolic Effects of Non-absorbable Carbohydrates

Jenkins

Popovich

Kendall

et al. 1997

Scandinavian Journal of Gastroenterology

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Food components which are incompletely absorbed in the small intestine or not absorbed at all but are delivered to the colon have been part of the diet throughout the course of human evolution. Our great ape cousins may derive 30% or more of their dietary calories from colonic uptake of short-chain fatty acids (SCFAs) generated in the colon. The metabolic effects of dietary carbohydrate entering the colon are many and include laxation, the growth of the fecal biomass, nitrogen entrapment and SCFA generation. These SCFAs in turn may nourish mucosal cells, spare glutamine utilization, enhance hepatic gluconeogenesis and lipogenesis and possibly influence renal handling of uric acid. The health implications are significant in terms of modifying risk factors for disease and disease prevention and justify interest in the metabolic effects of non-absorbable sugars such as lactulose.

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Passage of carbohydrate into the colon

Cited by 296 publications

References 20 publications

Interactive effects of dietary crude protein and fermentable carbohydrate levels on odour from pig manure

Interactive effects of dietary crude protein and fermentable carbohydrate levels on odour from pig manure

Dietary factors affecting the proliferation of epithelial cells in the mouse colon

Metabolic Effects of Non-absorbable Carbohydrates

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