An emerging scientific literature is investigating the construct of ''compassionate love,'' love that is ''centered on the good of the other,'' a construct empirically linked to physical and mental health. We evaluated effects of an 8-week, 16-hour programme for physicians, nurses, chaplains, and other health professionals, using nonsectarian, spiritually based, self-management tools. Participants were randomised to intervention (n ¼ 30) or wait-list (n ¼ 31). Pretest, post-test, 8-and 19-week follow-up data were gathered on six measures of prosocial qualities. Favorable treatment effects ( p50.05) were found for compassionate love (d ¼ 0.49), altruistic actions (d ¼ 0.33), perspective-taking (d ¼ 0.42), and forgiveness (d ¼ 0.61). Treatment adherence fully mediated effects on compassionate love. Furthermore, stress reduction mediated treatment effects on compassionate love, perspective-taking, and forgiveness; each also mediated gains in caregiving self-efficacy. This encouraging evidence suggests that nonlaboratory psychospiritual interventions can boost compassionate love to benefit the recipients and the larger society.