Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver

Dongil, Pilar; Pérez-García, Ana; Hurtado-Carneiro, Verónica; Herrero‐de‐Dios, Carmen; Blázquez, Enrique; Álvarez, Elvira; Sanz, Carmen

doi:10.1038/s41598-018-32192-w

Cited by 14 publications

(22 citation statements)

References 82 publications

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“…Our studies indicate that the role of PASK in hepatic metabolism is especially important in the adaptation to fasting/ feeding states, where PASK deficiency influences the expression of several transcription factors and key enzymes in different metabolic pathways (49)(50)(51)(52). Figure 2A therefore provides a summary of the more salient effects of PASK deficiency at transcriptional level observed in baseline conditions (nonfasted) and under fasting.…”

Section: Pask and The Nutritional Adaptation Of The Livermentioning

confidence: 79%

“…In this situation, PASK regulates many mitochondrial functions in liver, from biogenesis to mitochondrial dynamics, playing a role in maintaining mitochondrial quality and antioxidant response mechanisms. Figure 2A shows the changes observed at transcriptional level of genes involved in hepatic oxidative stress metabolism and mitochondrial dynamics in PASK-deficient mice under non-fasting and fasting states (51). Likewise, PASK deficiency under fasting conditions induces the overexpression of antioxidant enzymes in liver, such as Glutamate-cysteine ligase (GCLm), Heme Oxygenase 1 (HO1), and proteins that modulate mitochondrial dynamics and mitophagy as Mitofusin 1/2 (MFN1/2), Optic atrophy 1 (OPA1), Mitochondrial receptor protein, Fission 1 (FIS1), BCL2 and adenovirus E1B 19-kDa-interacting protein (BNIP3) and Phosphatase and Tensin homolog (PTEN)-induced kinase 1 (PINK1) (51).…”

Section: Pask and The Nutritional Adaptation Of The Livermentioning

confidence: 99%

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PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions

Hurtado-Carneiro¹,

Pérez-García²,

Álvarez³

et al. 2020

Front. Endocrinol.

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The protein kinase with PAS domains (PASK) is a nutrient and energy sensor located in the cells of multiple organs. Many of the recent findings for understanding PASK functions in mammals have been reported in studies involving PASK-deficient mice. This minireview summarizes the PASK role in the control of fasting and feeding responses, focusing especially on the hypothalamus and liver. In 2013, PASK was identified in the hypothalamic areas involved in feeding behavior, and its expression was regulated under fasting/refeeding conditions. Furthermore, it plays a role in coordinating the activation/inactivation of the hypothalamic energy sensors AMPK and mTOR/S6K1 pathways in response to fasting. On the other hand, PASK deficiency prevents the development of obesity and non-alcoholic fatty liver in mice fed with a high-fat diet. This protection is explained by the re-establishment of several high-fat diet metabolic alterations produced in the expression of hepatic transcription factors and key enzymes that control the main metabolic pathways involved in maintaining metabolic homeostasis in fasting/feeding responses. This minireview covers the effects of PASK inactivation in the expression of certain transcription factors and target enzymes in several metabolic pathways under situations such as fasting and feeding with either a standard or a high-fat diet.

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Section: Pask and The Nutritional Adaptation Of The Livermentioning

confidence: 79%

Section: Pask and The Nutritional Adaptation Of The Livermentioning

confidence: 99%

PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions

Hurtado-Carneiro¹,

Pérez-García²,

Álvarez³

et al. 2020

Front. Endocrinol.

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“…The PAS kinase is a sensory protein kinase responsive to light, oxygen, nutrients and stress status as well as redox state (Dongil et al, 2018;Ponting & Aravind, 1997). The PSK1 and PSK2 are two PAS kinase homologues in S. cerevisiae.…”

Section: Discussionmentioning

confidence: 99%

PSK1 coordinates glucose metabolism and utilization and regulates energy‐metabolism oscillation in Saccharomyces cerevisiae

Huang

Ouyang

et al. 2020

Yeast

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Energy‐metabolism oscillations (EMO) are ultradian biological rhythms observed in in aerobic chemostat cultures of Saccharomyces cerevisiae. EMO regulates energy metabolism such as glucose, carbohydrate storage, O2 uptake, and CO2 production. PSK1 is a nutrient responsive protein kinase involved in regulation of glucose metabolism, sensory response to light, oxygen, and redox state. The aim of this investigation was to assess the function of PSK1 in regulation of EMO. The mRNA levels of PSK1 fluctuated in concert with EMO, and deletion of PSK1 resulted in unstable EMO with disappearance of the fluctuations and reduced amplitude, compared with the wild type. Furthermore, the mutant PSK1Δ showed downregulation of the synthesis and breakdown of glycogen with resultant decrease in glucose concentrations. The redox state represented by NADH also decreased in PSK1Δ compared with the wild type. These data suggest that PSK1 plays an important role in the regulation of energy metabolism and stabilizes ultradian biological rhythms. These results enhance our understanding of the mechanisms of biorhythms in the budding yeast.

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“…Dongil et al 63 examined fasting and mitophagy using a PAS Domain Kinase (PASK) deficient model. This study recruited both wild type or PASK deficient male mice that were 12-20 weeks old.…”

Section: Fasting or Calorie Restriction And Mitophagymentioning

confidence: 99%

The effect of fasting or calorie restriction on mitophagy induction: a literature review

Mehrabani

Bagherniya

Askari

et al. 2020

J cachexia sarcopenia muscle

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Mitochondrial dysfunction can be a major cause of a wide range of age-related diseases. Maintaining the normal homeostasis of mitochondria population plays an important role in ensuring people's health, which is done through the mitophagy process. Among the various stimuli for the onset of mitophagy, caloric restriction (CR) is one of the strongest non-genetic triggers for initiating the mitophagy process. The primary objective of this paper is to review the literature assessing the effect of CR on mitophagy. Medline, Web of Science, Scopus, and Google Scholar databases was searched from inception to 1 August 2019. Reference lists from all selected articles were also examined for additional relevant studies. The evidence regarding the effect of fasting or CR on mitophagy is still limited. In addition, the methodological approaches of the studies are too heterogeneous in terms of types of food restriction, study duration, and targeted tissues. Most of the studies showed that fasting or CR induced mitophagy and mitophagy-related markers such as Binp3 and Parkin. However, some studies demonstrated that mitophagy occurred both in fasting and fed state with no significant differences or may be induced in fed state. Study on the muscle tissue of subjects after exercise showed that mitophagy was upregulated in the fed state. It has been demonstrated that mitophagy in the muscle was lowered in the absence of AMP-dependent kinase and fibroblast growth factor 21 genes, both in fasted and fed conditions. Current evidence overwhelmingly suggests that CR and fasting induce mitophagy and mitophagy-related markers. Based on the current evidence that we reviewed here, it could be concluded that fasting or CR has a promising role as a novel and practical approach in the prevention of age-related diseases without any side effects by inducing mitophagy in different organs of the body. More studies will be required in future to clarify the relationship between food deprivation and mitophagy. Further studies using a variety of different types of CR and fasting states are also warranted to determine the best approach for inducing mitophagy and improving health.

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Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver

Cited by 14 publications

References 82 publications

PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions

PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions

PSK1 coordinates glucose metabolism and utilization and regulates energy‐metabolism oscillation in Saccharomyces cerevisiae

The effect of fasting or calorie restriction on mitophagy induction: a literature review

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