Parvovirus-Like Particles in Human Sera

Cossart, Yvonne E.; Cant, Barbara; Field, Anne M.; Widdows, Dominic

doi:10.1016/s0140-6736(75)91074-0

Cited by 847 publications

(376 citation statements)

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“…None of the sera from 40 cases diagnosed at this hospital were found to contain the PVLA antigen, and only some 500 of these patients had specific antibody detectable by CIE. The proportion of non-A, non-B hepatitis patients with antibody to PVLA is consistent with both our own experience and those of Cossart et al (1975) and Paver & Clarke (1976) who report that slightly more than 30 % of the population have antibody detectable by either CIE or immune electron microscopy by the age of 16 years. Thus experience of PVLA infection appears no more common among patients with non-A, non-B hepatitis than among the normal population.…”

supporting

confidence: 91%

“…These specimens were then examined by electron microscopy, and were found to contain not the characteristic pleiomorphic particles of HBsAg but smaller, spherical particles with a relatively uniform diameter of 23 nm. The virus recovered from one of these units of blood was designated B19 (Cossart et al 1975). In the same communication these workers reported finding an apparently indentical virus in blood samples from two further persons; one of these was a patient who had received a renal transplant one week earlier, while the second was a patient suffering acute hepatitis.…”

mentioning

confidence: 99%

“…The defective adeno-associated parvoviruses are not uncommonly found in faeces, together with their helper, adenovirus. The B19 agent exhibits no antigenic relationship with the adeno-associated parvoviruses (Cossart et al 1975) and has not been reported as occurring together with either adenovirus or members of the alternative 'helper' genus, the herpes viruses; rather it has come to be regarded as a virus fully capable of independent replication. Particles morphologically very similar to B19 have been found in faecal specimens in the absence of helper virus, nevertheless (Paver et al 1973).…”

mentioning

confidence: 99%

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The emerging story of a human parvovirus-like agent

Anderson

1982

J. Hyg.

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It is now seven years since Cossart and her co-workers reported finding a novel parvovirus-like agent (PVLA) infecting man. Although this virus was found as a systemic infection in both Dr Cossart's eleven subjects and a further four subjects described subsequently (Paver & Clarke, 1976; Schneerson, Mortimer & Vandervelde, 1980) it was not until 1981 that a clearly defined clinical syndrome was identified as attributable to infection with this agent. Work in the Departments of Microbiology and Haematology, King's College Hospital Medical School and collaboration with the MRC laboratory at Kingston, Jamaica has shown that infection with the PVLA is the major cause of aplastic crisis in children with sickle cell anaemia (Sergeant et al. 1981, Anderson et al. 1982a, b).

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supporting

confidence: 91%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The emerging story of a human parvovirus-like agent

Anderson

1982

J. Hyg.

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“…In immunocompromised patients, PVB19 infection may lead to persistent anemia and variable degrees of pure red cell aplasia that is sometimes associated with thrombocytopenia and neutropenia. A bone marrow examination shows the characteristic giant pronormoblasts [29,30]. The presence of normoblasts in the bone marrow, as well as the absence of giant proerythroblasts in our case, is quite different from the findings in chronic bone marrow failure induced by PVB19 infection in immunocompromised hosts [2,19].…”

Section: Discussioncontrasting

confidence: 68%

Successful treatment of severe aplastic anemia associated with human parvovirus B19 and Epstein‐Barr virus in a healthy subject with allo‐BMT

et al. 2001

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Several reports have noted pancytopenia associated with Human parvovirus B19 (PVB19)or Ebstein-Barr virus (EBV) infections in patients who have no history of immunodeficiency. To our knowledge, we report the first case of severe aplastic anemia associated with both EBV and PVB19 infections in a previously healthy 22-year-old man. He was admitted to our hematology service due to anemia and thrombocytopenia. He had no symptoms or signs of infections of these viruses. His bone marrow biopsy revealed a hypocellular marrow. Specific IgM and IgG antibodies to EBV and PVB19 were elevated. EBV and PVB19 virus genomes were detected by PCR in the bone marrow nucleated cells and the peripheral blood lymphocytes. Two months after treatment with prednisone, acyclovir, and intravenous immune globulin (IVIg), the genomes of both these viruses disappeared. However, his transfusion requirement for platelet suspensions and packed red blood cells persisted. The patient underwent allogeneic bone marrow transplant (allo-BMT) and has had an enduring complete hematological response for 8 months. Am.

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“…Human parvoviru s B 1 9 wa s firs t foun d i n serum o f largely symptomless blood donors 6 an d has subsequentl y bee n associated with non-specific febril e illness 18 , aplasti c crise s i n chroni c haemolytic anaemias 2 7 9 1 7 and acute arthritis 15 20 . I n addition , huma n parvoviru s B 1 9 wa s shown t o caus e erythem a infectiosu m (EI ) o r "fifth disease", an acute exanthem o f childhood 4 .…”

Section: Introductionmentioning

confidence: 99%