Parvovirus B19 induced lupus-like syndrome with nephritis

Georges, Elodie; Rihova, Zuzana; Čmejla, Radek; Decleire, Pierre-Yves; Langen, C. D. Dé

doi:10.1080/17843286.2015.1111673

Cited by 14 publications

(17 citation statements)

References 5 publications

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“…Clinical and serological manifestations are similar between parvovirus B19 and SLE, but parvovirus B19 infection does not complete the four diagnostic criteria for SLE of the American College of Rheumatology, permitting its differential diagnosis. Parvovirus B19 infection triggers the production of cytokines and autoantibodies that are also present in the serum of patients with SLE, e.g.…”

Section: Introductionmentioning

confidence: 99%

Infectious processes and systemic lupus erythematosus

et al. 2019

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Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding of the interactions between infectious agents and the host, explaining the interest in gathering updated scientific information on this topic. According to the literature, the pathogens most frequently associated with SLE are viruses, notably human endogenous retroviruses, Epstein-Barr virus, parvovirus B19, cytomegalovirus and human immunodeficiency virus type 1, alongside certain bacterial components that can also trigger activation of the immune system. The mechanisms underlying autoreactivity remain unclear but various explanations have been proposed, including immunological changes responsible for infectious processes or molecular mimicry between host structures and those of infectious agents.

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Section: Introductionmentioning

confidence: 99%

Infectious processes and systemic lupus erythematosus

et al. 2019

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“…Molecular mimicry could be a major pathogenic mechanism triggering the production of auto-antibodies after PVB19 infection [ 28 ]. Several reports have described lupus-like manifestations related to PVB19 infection, including some with acute glomerulonephritis, with transient positive anti-nuclear or anti-dsDNA antibodies [ 29 ]. In a murine model, the injection of apoptotic bodies containing dsDNA modified by PVB19 induced the production of anti-dsDNA antibodies and immune-mediated organ damage [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy

et al. 2020

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Background: The seroprevalence of human Parvovirus B19 (PVB19) is 70-85% in adults worldwide. PVB19 is the etiologic agent of the fifth disease, is a cause of aplastic anemia, and can be associated with kidney injury. We aimed to describe the cases of 4 patients with kidney injury related to PVB19 primary infection, and to evaluate the seroprevalence of PVB19 and the incidence of PVB19 primary infection in patients undergoing a native kidney biopsy. Methods: Cases of PVB19 infection with kidney injury were reviewed from the archives of the department of Nephrology. A systematic screening of anti-PVB19 IgG and IgM antibodies and viral DNA was performed in sera from 100 consecutive patients with a kidney biopsy in 2017-2018. Results: The 4 patients with PVB19 infection-associated kidney disease displayed: one lupus-like glomerulonephritis (GN) without lupus auto-antibodies, one minimal change disease with tubular necrosis, one secondary hemolytic and uremic syndrome and one membrano-proliferative GN. In the 100 patients biopsied, 67 had elevated anti-PVB19 IgG, among whom 8 had elevated IgM, without circulating viral DNA, without any particular renal pathological pattern. One additional patient showed a seroconversion at the time of kidney biopsy, which revealed a class V lupus nephritis. Conclusion: PVB19 primary infection can be associated with different kidney diseases. The seroprevalence of PVB19 among patients with a kidney biopsy is similar to the overall population, and primary infection is rarely documented (1%) after systematic screening. Whether PV19 is nephrotoxic, or triggers renal endothelial injury and immune activation, remains to be elucidated.

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“…Although PVB19 infection may be involved in the pathogenesis of (auto)immune-mediated diseases, as an infectious trigger, the correct diagnosis of PVB19 infection is particularly important in this setting, to avoid an inadequate and potentially harmful immunosuppressive therapy in some patients (29,31).…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy.

Kauffmann

Bobot

Daniel

et al. 2020

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BACKGROUND: The seroprevalence of human Parvovirus B19 (PVB19) is 70-85 % in adults worldwide. PVB19 is the etiologic agent of the fifth disease, is a cause of aplastic anemia, and can be associated with kidney injury. We aimed to describe the cases of 4 patients with kidney injury related to PVB19 primary infection, and to evaluate the seroprevalence of PVB19 and the incidence of PVB19 primary infection in patients undergoing a native kidney biopsy.METHODS: Cases of PVB19 infection with kidney injury were reviewed from the archives of the department of Nephrology. A systematic screening of anti-PVB19 IgG and IgM antibodies and viral DNA was performed in sera from 100 consecutive patients with a kidney biopsy in 2017-2018.RESULTS: The 4 patients with PVB19 infection-associated kidney disease displayed: one lupus-like glomerulonephritis (GN) without lupus auto-antibodies, one minimal change disease with tubular necrosis, one secondary hemolytic and uremic syndrome and one membrano-proliferative GN. In the 100 patients biopsied, 67 had elevated anti-PVB19 IgG, among whom 8 had elevated IgM, without circulating viral DNA, without any particular renal pathological pattern. One additional patient showed a seroconversion at the time of kidney biopsy, which revealed a class V lupus nephritis. CONCLUSION: PVB19 primary infection can be associated with different kidney diseases. The seroprevalence of PVB19 among patients with a kidney biopsy is similar to the overall population, and primary infection is rarely documented (1%) after systematic screening. Whether PV19 is nephrotoxic, or triggers renal endothelial injury and immune activation, remains to be elucidated.

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Parvovirus B19 induced lupus-like syndrome with nephritis

Cited by 14 publications

References 5 publications

Infectious processes and systemic lupus erythematosus

Infectious processes and systemic lupus erythematosus

Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy

Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy.

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