Parvovirus as a Differential Diagnosis of Hydrops fetalis in the First Trimester

Sohan, Karen; Carroll, Stephen; Byrne, Dominic; Ashworth, Michael; Soothill, Peter

doi:10.1159/000021013

Cited by 28 publications

(11 citation statements)

References 10 publications

(10 reference statements)

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“…None of the fetuses were affected. Parvovirus B19 is the only specific pathogen associated with increased nuchal translucency, leading to myocardial dysfunction or fetal anemia [38]. Parvovirus B19 is the only specific pathogen associated with increased nuchal translucency, leading to myocardial dysfunction or fetal anemia [38].…”

Section: Chance Of Maternal and Fetal Infectionmentioning

confidence: 99%

Increased nuchal translucency in the presence of normal chromosomes

Alamillo

Fiddler

Pergament

2012

Current Opinion in Obstetrics &Amp; Gynecology

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Section: Chance Of Maternal and Fetal Infectionmentioning

confidence: 99%

Increased nuchal translucency in the presence of normal chromosomes

Alamillo

Fiddler

Pergament

2012

Current Opinion in Obstetrics &Amp; Gynecology

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“…They may warn of a possible intrauterine infection; in the case of non-immune hydrops, for example, parvovirus B19 infection and adenovirus infection [1][2][3] may occur. They may also be indicative of other pathologies accompanied with fetal anaemia, including thalassaemia [4] , twin-to-twin transfusion [5] , and disorders of fetal circulation and abnormal anatomy of the fetal heart [1] .…”

mentioning

confidence: 99%

Incidence of Chromosomal Abnormalities in the Presence of Fetal Subcutaneous Oedema, Such as Nuchal Oedema, Cystic Hygroma and Non-Immune Hydrops

Beke¹,

Joó²,

Csaba³

et al. 2009

Fetal Diagn Ther

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Introduction: The authors investigated the incidence of chromosomal abnormalities in subcutaneous oedema detected in the fetus by intrauterine ultrasonography. Material and Method: In the 10-year period, intrauterine karyotyping was performed in pregnancies with positive ultrasound findings for subcutaneous oedema, such as nuchal oedema, cystic hygroma and non-immune hydrops. Results: Intrauterine karyotyping in fetal subcutaneous oedema was carried out in 434 cases. The chromosomal investigation was made in nuchal oedema in 374 cases, in 120 patients the chromosomal examination was made in the first trimester because of nuchal translucency, and in 254 cases in the second trimester because of nuchal thickening. Cystic hygroma cases (27 patients), non-immune hydrops cases (20 patients), and combined cases of non-immune hydrops and cystic hygroma (13 patients) were investigated separately. In nuchal oedema, pathological karyotypes were detected in 8.33% in the first trimester and in 5.51% in the second trimester. Chromosomal abnormality was found in 48.15, 20, and 53.8% in cystic hygroma, non-immune hydrops, and combined occurrence of non-immune hydrops and cystic hygroma, respectively. Considering all of the changes accompanied by subcutaneous oedema, 50, 25 and 18.75% of the pathological karyotypes was X-monosomy, trisomy 18 and trisomy 21, respectively. Discussion: It was important to distinguish nuchal oedema and cystic hygroma, and in the case of non-immune hydrops, it was also important to discuss cases with or without cystic hygroma separately. During the investigations, cases of non-immune hydrops with or without cystic hygroma were evaluated as separate categories. Conclusions: The authors emphasize the differentiation of the various types of subcutaneous oedema and the importance of precise information about the risks, provided during genetic counselling.

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“…Fetal infection is often cited as a possible cause for increased NT. Parvovirus B19 infection is the only specifi c pathogen associated with increased NT, most likely secondary to myocardial dysfunction or fetal anemia [ 64 ].…”

Section: Benefi Ts Of First-trimester Ultrasound In Detection Of Noncmentioning

confidence: 99%