PARVG Gene Polymorphism and Operational Renal Allograft Tolerance

Danger, Richard; Thervet, Éric; Grisoni, ML; Puig, Pierre Laurent; Pallier, Annaïck; Trégouët, David‐Alexandre; Lecorre, Delphine; Giral, Magali; Legendre, C.; Soulillou, Jean‐Paul; Brouard, Sophie

doi:10.1016/j.transproceed.2012.09.034

Cited by 9 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PARVG, a member of the parvin protein family, is an actin-binding protein associated with focal adhesion ( 28 ). Chen et al ( 29 ) revealed that four DNA methylation signatures (phospholipase C β2, Rac family small GTPase 2, vav guanine nucleotide exchange factor 1 and PARVG) are strongly associated with the prognosis of renal clear cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

The aim of the present study was to investigate transient receptor potential cation channel subfamily M member 2 (TRPM2), a promising therapeutic target and biomarker for pancreatic ductal adenocarcinoma (PDAC) prognosis, in addition to determining its effects regarding tumor progression and invasion. PDAC is a fatal disease with a poor prognosis, and its associated pathogenic molecular mechanisms remain to be determined. In the present study, combined analysis using genomic and transcriptomic data from two PDAC studies was performed to discover a survival-associated biomarker of PDAC. Survival analysis for genes mutated in ≥10 patients was performed using a Kaplan-Meier curve and tested for significance using a log-rank test. Furthermore, gene-expression correlation analysis was performed to determine the genes with the strongest correlations to TRPM2. In addition, a Cell Counting Kit-8 assay, a scratch wound-healing assay and a Transwell assay were performed in the present study to investigate the proliferative, invasive and metastatic ability of PANC-1 cells in TRPM2-overexpressing and downregulated groups. The mutated TRPM2 gene had a strong negative correlation with patient survival probability compared with the normal control group (P=1.06×10-4). Expression of TRPM2 was strongly correlated with expression of probable phospholipid-transporting ATPase IM, γ-parvin, tudor domain containing 9, Toll-like receptor 7 and Scm-like with four MBT domains protein 2 according to the criterion of a correlation coefficient >0.5. Furthermore, the results of the present study demonstrated that the TRPM2 overexpression in a PDAC cell line (PANC-1) promoted cell proliferation, invasion and metastatic ability. TRPM2 represents a potential therapeutic target and prognostic marker for patients with PDAC. TRPM2 regulates cell proliferation, invasion and migration; however, the underlying mechanism requires further investigation in future studies.

show abstract

Section: Discussionmentioning

confidence: 99%

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We ourselves recently showed that miRNA 142-3-p is up-regulated in B cells of OT patients with a stable expression over time. This study suggests that a negative feedback loop involving TGF-β signaling and miR-142-3p expression in B cells may contribute to the maintenance of tolerance (47). …”

Section: Part Ii: Regulatory B Cells In Human Tolerancementioning

confidence: 91%

Regulatory B Cells and Tolerance in Transplantation: From Animal Models to Human

et al. 2013

View full text Add to dashboard Cite

Until recently, the role of B cells in transplantation was thought to be restricted to producing antibodies that have been clearly shown to be deleterious in the long-term, but, in fact, B cells are also able to produce cytokine and to present antigen. Their role as regulatory cells in various pathological situations has also been highlighted, and their role in transplantation is beginning to emerge in animal, and also in human, models. This review summarizes the different studies in animals and humans that suggest a B-cell regulatory role in the transplant tolerance mechanisms.

show abstract

“…Fewer than 200 cases of kidney operational tolerance have been described over the last 40 years ( 62 ). Nevertheless, with the successful development of research consortia in this field, a number of transcriptional studies have been successfully undertaken ( 47 , 63 – 69 ). Very broadly, these reports presented gene lists converging toward a B cell signature of tolerance, and in so doing corroborated other data showing that both the percentage and the absolute number of B cells are increased in operationally tolerant kidney allograft recipients ( 64 , 65 , 70 , 71 ).…”

Section: Identification Of Tolerance Biomarkersmentioning

confidence: 99%

Emergent Transcriptomic Technologies and Their Role in the Discovery of Biomarkers of Liver Transplant Tolerance

2015

View full text Add to dashboard Cite

Liver transplantation offers a unique window into transplant immunology due, in part, to the considerable proportion of recipients who develop immunological tolerance to their allograft. Biomarkers are able to identify and predict such a state of tolerance, and thereby able to establish suitable candidates for the minimization of hazardous immunosuppressive therapies, are not only of great potential clinical benefit but might also shed light on the immunological mechanisms underlying tolerance and rejection. Here, we review the emergent transcriptomic technologies serving as drivers of biomarker discovery, we appraise efforts to identify a molecular signature of liver allograft tolerance, and we consider the implications of this work on the mechanistic understanding of immunological tolerance.

show abstract

PARVG Gene Polymorphism and Operational Renal Allograft Tolerance

Cited by 9 publications

References 21 publications

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

Regulatory B Cells and Tolerance in Transplantation: From Animal Models to Human

Emergent Transcriptomic Technologies and Their Role in the Discovery of Biomarkers of Liver Transplant Tolerance

Contact Info

Product

Resources

About