Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex

Povysheva, Nadezhda V.; Zaitsev, Aleksey V.; Rotaru, Diana C.; González‐Burgos, Guillermo; Lewis, David A.; Krimer, Leonid S.

doi:10.1152/jn.90396.2008

Cited by 103 publications

(93 citation statements)

References 77 publications

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“…Interneurons have also been studied in other species beside rodents. Although similar morphological features and marker expression have been observed in primates, some differences in electrophysiological properties have been reported between rats and monkeys (Povysheva et al, 2007; Povysheva et al, 2008; Zaitsev et al, 2005; Zaitsev et al, 2009). It seems that overall, the same basic interneuron subtypes exist across most mammalian species studied (DeFelipe, 2002).…”

Section: Interneuron Diversity In the Neocortexmentioning

confidence: 66%

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Tremblay

Lee

Rudy

2016

Neuron

1,554

1,730

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Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons which gate signal flow and sculpt network dynamics. Although they represent a minority of the total neocortical neuronal population, GABAergic interneurons are highly heterogeneous, forming functional classes based on their morphological, electrophysiological and molecular features as well as connectivity and in vivo patterns of activity. Here we review our current understanding of neocortical interneuron diversity and the properties that distinguish among cell types. We then discuss how the involvement of multiple cell types, each with a specific set of cellular properties, plays a crucial role in diversifying and increasing the computational power of a relatively small number of simple circuit motifs forming cortical networks. We illustrate how recent advances in the field have shed light onto the mechanisms by which GABAergic inhibition contributes to network operations.

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Section: Interneuron Diversity In the Neocortexmentioning

confidence: 66%

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Tremblay

Lee

Rudy

2016

Neuron

1,554

1,730

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“…Some of the electrophysiological parameters from all monkey and rat FS BCs and from all monkey ChCs were published previously [18], [20]. Here, in addition, a new critical electrophysiological parameter, medium afterhyperpolarization (mAHP) amplitude, was measured in the recordings from the interneurons.…”

Section: Methodsmentioning

confidence: 99%

“…Then, the AR coefficient was estimated from the linear regression of AR versus current at 60 pA above rheobase. The level of 60 pA above rheobase was chosen for estimation of frequency and AR coefficient since it was the lowest stimulation current intensity to produce relatively regular firing in rat FS BCs with very few quiescent periods [20].…”

Section: Methodsmentioning

confidence: 99%

“…In order to clarify these issues, here, we compared the intrinsic membrane properties of ChCs and BCs in the rat and macaque monkey prefrontal cortex (PFC), the cortical region that differs most substantially between these two species [19]. In our previous studies, we examined the electrophysiological classification of interneurons in monkey PFC [6], [16]–[18], and compared BCs in rat and monkey PFC [20]. Here, for the first time, we compared properties of ChCs from monkey and rat and report interspecies differences for a number of these properties.…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells

et al. 2013

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In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target the perisomatic region of pyramidal neurons, chandelier cells (ChCs) and basket cells (BCs), are generally thought to have the same “fast-spiking” phenotype, which is characterized by a short action potential and high frequency firing without adaptation. However, findings from studies in different species suggest that certain electrophysiological membrane properties might differ between these two cell classes. In this study, we assessed the physiological heterogeneity of fast-spiking interneurons as a function of two factors: species (macaque monkey vs. rat) and morphology (chandelier vs. basket). We showed previously that electrophysiological membrane properties of BCs differ between these two species. Here, for the first time, we report differences in ChCs membrane properties between monkey and rat. We also found that a number of membrane properties differentiate ChCs from BCs. Some of these differences were species-independent (e.g., fast and medium afterhyperpolarization, firing frequency, and depolarizing sag), whereas the differences in the first spike latency between ChCs and BCs were species-specific. Our findings indicate that different combinations of electrophysiological membrane properties distinguish ChCs from BCs in rodents and primates. Such electrophysiological differences between ChCs and BCs likely contribute to their distinctive roles in cortical circuitry in each species.

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“…In monkey and rat prefrontal cortex, basket cells also do not plateau, almost linearly increasing firing frequency (Povysheva et al, 2008). On the other hand, pyramidal cells in mouse neocortex plateau below gamma band frequency, even after application of very high amplitude current steps (600–1000 pA; Zhou et al, 2010).…”

Section: Coherence and Frequencymentioning

confidence: 99%

Gamma Band Activity in the Reticular Activating System

Urbano¹,

Kezunovic²,

Hyde³

et al. 2012

Front. Neur.

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This review considers recent evidence showing that cells in three regions of the reticular activating system (RAS) exhibit gamma band activity, and describes the mechanisms behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus (PPN), intralaminar parafascicular nucleus (Pf), and pontine subcoeruleus nucleus dorsalis (SubCD) all fire in the beta/gamma band range when maximally activated, but no higher. The mechanisms behind this ceiling effect have been recently elucidated. We describe recent findings showing that every cell in the PPN have high-threshold, voltage-dependent P/Q-type calcium channels that are essential, while N-type calcium channels are permissive, to gamma band activity. Every cell in the Pf also showed that P/Q-type and N-type calcium channels are responsible for this activity. On the other hand, every SubCD cell exhibited sodium-dependent subthreshold oscillations. A novel mechanism for sleep–wake control based on well-known transmitter interactions, electrical coupling, and gamma band activity is described. The data presented here on inherent gamma band activity demonstrates the global nature of sleep–wake oscillation that is orchestrated by brainstem–thalamic mechanism, and questions the undue importance given to the hypothalamus for regulation of sleep–wakefulness. The discovery of gamma band activity in the RAS follows recent reports of such activity in other subcortical regions like the hippocampus and cerebellum. We hypothesize that, rather than participating in the temporal binding of sensory events as seen in the cortex, gamma band activity manifested in the RAS may help stabilize coherence related to arousal, providing a stable activation state during waking and paradoxical sleep. Most of our thoughts and actions are driven by pre-conscious processes. We speculate that continuous sensory input will induce gamma band activity in the RAS that could participate in the processes of pre-conscious awareness, and provide the essential stream of information for the formulation of many of our actions.

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Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex

Cited by 103 publications

References 77 publications

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells

Gamma Band Activity in the Reticular Activating System

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