Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice

Tanahira, Chiyoko; Higo, Shigeyoshi; Watanabe, Keisuke; Tomioka, Ryohei; Ebihara, Satoe; Kaneko, Takeshi; Tamamaki, Nobuaki

doi:10.1016/j.neures.2008.12.007

Cited by 100 publications

(86 citation statements)

References 28 publications

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“…In addition, tdTomato-positive but PV-negative cells were, at least in part, SST-or calretinin-positive GABAergic neurons (Supplementary Figure S1 and Supplementary Table S1). Thus, Cre activity in the PV-Cre mouse was detected in a subset of GABAergic neurons, primarily in PV neurons, which is consistent with a previous study (Tanahira et al, 2009).…”

Section: Gad67 and Gaba Levels Were Reduced In Mice Lacking Gad67 Prisupporting

confidence: 92%

“…As previously reported, Cre expression was detected primarily in PV-positive GABAergic neurons but also in certain other subtypes of GABAergic and pyramidal neurons (Tanahira et al, 2009). Because we focused on GABAergic neurons, we crossed the PV-Cre mouse with a VGAT-floxed STOP-tdTomato transgenic mouse.…”

Section: Gad67 and Gaba Levels Were Reduced In Mice Lacking Gad67 Prisupporting

confidence: 81%

“…PV-Cre; GAD67 flox/flox and PV-Cre; GAD67 flox/+ mice were generated by crossing Pvalb-Cre BAC transgenic (Tg(Pvalb-cre); hereafter, PV-Cre) mice (Tanahira et al, 2009) and GAD67-floxed (Gad1 Tm1 ) mice (Obata et al, 2008). In behavioral tests and acute slice electrophysiology, male PV-Cre; GAD67 flox/+ mutant mice and littermate male controls (GAD67 flox/+ ) were used.…”

Section: Animalsmentioning

confidence: 99%

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Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes

Fujihara

Miwa

Kakizaki

et al. 2015

Neuropsychopharmacol

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Decreased expression of the GABA synthetic enzyme glutamate decarboxylase 67 (GAD67) in a subset of GABAergic neurons, including parvalbumin (PV)-expressing neurons, has been observed in postmortem brain studies of schizophrenics and in animal models of schizophrenia. However, it is unclear whether and how the perturbations of GAD67-mediated GABA synthesis and signaling contribute to the pathogenesis of schizophrenia. To address this issue, we generated the mice lacking GAD67 primarily in PV neurons and characterized them with focus on schizophrenia-related parameters. We found that heterozygous mutant mice exhibited schizophrenia-related behavioral abnormalities such as deficits in prepulse inhibition, MK-801 sensitivity, and social memory. Furthermore, we observed reduced inhibitory synaptic transmission, altered properties of NMDA receptor-mediated synaptic responses in pyramidal neurons, and increased spine density in hippocampal CA1 apical dendrites, suggesting a possible link between GAD67 deficiency and disturbed glutamatergic excitatory synaptic functions in schizophrenia. Thus, our results indicate that the mice heterozygous for GAD67 deficiency primarily in PV neurons share several neurochemical and behavioral abnormalities with schizophrenia, offering a novel tool for addressing the underlying pathophysiology of schizophrenia.

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Section: Gad67 and Gaba Levels Were Reduced In Mice Lacking Gad67 Prisupporting

confidence: 92%

Section: Gad67 and Gaba Levels Were Reduced In Mice Lacking Gad67 Prisupporting

confidence: 81%

Section: Animalsmentioning

confidence: 99%

See 1 more Smart Citation

Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes

Fujihara

Miwa

Kakizaki

et al. 2015

Neuropsychopharmacol

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“…Excitatory projections from dLGN to the visual cortex send collaterals to the visual sector of the reticular thalamic nucleus (RTN) (Rafols and Valverde, 1973;Baldauf, 2010). In return the RTN, which is rich in PV-ir neurons (Jones and Hendry, 1989;Tanahira et al, 2009), sends GABA-mediated inhibitory projections back to the thalamus. The visual cortex sends glutamatergic excitatory projections back to dLGN with collaterals to RTN (Alexander et al, 2006;Petrof et al, 2012;Jurgens et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Visual thalamocortical circuits in parvalbumin-deficient mice

Lintas¹,

Schwaller²,

Villa³

2013

Brain Research

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“…Mice can be engineered to express fluorescent reporters of neural activity in genetically targeted circuit elements (Li et al 2005;Zariwala et al 2012). In addition, Cre-driver mouse lines targeting specific cell types (Lindeberg et al 2004;Tanahira et al 2009;Taniguchi et al 2011;Zariwala et al 2012) have made a growing array of circuit components genetically targetable for studies seeking to examine their respective roles in neural computation. In recent years, experiments combining use of imaging techniques with behavior in mice have exploited these advantages using various head-fixed preparations (Andermann et al 2010;Dombeck et al 2007;Komiyama et al 2010).…”

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confidence: 99%

Choice ball: a response interface for two-choice psychometric discrimination in head-fixed mice

Sanders

Kepecs

2012

Journal of Neurophysiology

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Sanders JI, Kepecs A. Choice ball: a response interface for twochoice psychometric discrimination in head-fixed mice. J Neurophysiol 108: 3416 -3423, 2012. First published September 26, 2012 doi:10.1152/jn.00669.2012The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparations provide an unparalleled opportunity to observe and control neural circuits. To investigate how neural circuits produce behavior, these methods need to be paired with equally well-controlled and monitored behavioral paradigms. Here, we introduce the choice ball, a response device that enables two-alternative forcedchoice (2AFC) tasks in head-fixed mice based on the readout of lateral paw movements. We demonstrate the advantages of the choice ball by training mice in the random-click task, a two-choice auditory discrimination behavior. For each trial, mice listened to binaural streams of Poisson-distributed clicks and were required to roll the choice ball laterally toward the side with the greater click rate. In this assay, mice performed hundreds of trials per session with accuracy ranging from 95% for easy stimuli (large interaural click-rate contrast) to near chance level for low-contrast stimuli. We also show, using the record of individual paw strokes, that mice often reverse decisions they have already initiated and that decision reversals correlate with improved performance. The choice ball enables head-fixed 2AFC paradigms, facilitating the circuit-level analysis of sensory processing, decision making, and motor control in mice.

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Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice

Cited by 100 publications

References 28 publications

Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes

Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes

Visual thalamocortical circuits in parvalbumin-deficient mice

Choice ball: a response interface for two-choice psychometric discrimination in head-fixed mice

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