Parvalbumin-lmmunoreactive Neurons in the Neocortex are Resistant to Degeneration in Alzheimerʼs Disease

Hof, Patrick R.; Cox, Kevin; Young, Warren G.; Celio, Marco R.; Rogers, Joseph; Morrison, John H.

doi:10.1097/00005072-199107000-00006

Cited by 171 publications

(74 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The normal samples (n=3) were from regions which showed a normal cytoarchitecture in Nissl-stained sections and a normal pattern of staining for PV. This normal pattern of PV immunostaining was similar to that previously described in the normal human neocortex (Hof et al 1991;Ferrer et al 1991;Marco et al 1996). The abnormal re-4 Fig.…”

Section: Resultssupporting

confidence: 87%

Altered synaptic circuitry in the human temporal neocortex removed from epileptic patients

Marco

DeFelipe

1997

Exp Brain Res

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 87%

Altered synaptic circuitry in the human temporal neocortex removed from epileptic patients

Marco

DeFelipe

1997

Exp Brain Res

View full text Add to dashboard Cite

“…Further, cells with still detectable CG-1 signal following exposure to BAPTA were more likely to express one of these CaBPs, suggesting cell survival may be linked to expression of these proteins, in general agreement with other studies (Hof et al, 1991;Mattson et al, 1991;Freund et al, 1992;Iacopino et al, 1992;Burke and Baimbridge, 1993;Lukas and Jones, 1994;Prendergast et al, 2001;Mulholland et al, 2003) (though see (Mockel and Fischer, 1994;Airaksinen et al, 1997;Klapstein et al, 1998;Bouilleret et al, 2000;Isaacs et al, 2000)). The data we describe here are consistent with our hypothesis that loss of calcium triggers apoptotic injury in the developing brain and is inversely related to expression of CB, CR, and PV (Lema Tome et al, 2006b).…”

Section: -Discussionsupporting

confidence: 91%

Loss of calcium and increased apoptosis within the same neuron

et al. 2007

View full text Add to dashboard Cite

Loss of neuronal calcium is associated with later apoptotic injury but observing reduced calcium and increased apoptosis in the same cell would provide more definitive proof of this apparent correlation. Thus, following exposure to vehicle or the calcium chelator BAPTA (1-20 μM), primary cortical neurons were labeled with Calcium Green-1 which was then cross-linked with EDAC, prior to immunostaining for various proteins. We found that BAPTA-induced changes in calcium were highly correlated with changes in expression of activated caspase-3 as well as the calcium binding proteins calbindin, calretinin, and parvalbumin. Additionally, in brain slices from P7 neonatal rats, BAPTA induced significant loss of calcium in a brain region we have previously shown to express only moderate levels of calcium binding proteins as well as display robust apoptosis following calcium entry blockade. In contrast, BAPTA had little influence on calcium levels in a brain region we have previously shown to express robust calcium binding proteins as well as display far less apoptosis following calcium entry blockade. These data suggest that the ability of developing neurons to buffer changes in calcium may be critical to their long-term survival.

show abstract

“…In addition, a decrease in parvalbumin-immunoreactive cortical pyramidal neurons was reported [30]. However, other studies showed a relative resistance of these cells [31,32] and the presence of parvalbumin-immunoreactive abnormal neuritis and aberrant sprouts [33]. Therefore, not all AD patients exhibited alteration of the GABAergic system.…”

Section: Discussionmentioning

confidence: 99%

Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin

Jeong¹,

Chang²,

Hwang³

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: Previous studies used 192 IgG-saporin to study cholinergic function because of its facility for selective lesioning; however, results varied due to differences in the methods of administration and behavioral tests used. We examined an animal model of dementia using 192 IgG-saporin to confirm its features before applying this model to research of therapeutic drugs or electrical stimulation techniques. Methods: Features were verified by the Morris water maze test, immunochemistry, and Western blotting. Animals were examined after intraventricular injection of 192 IgG-saporin (0.63 µg/µl; 6, 8, and 10 µl) or phosphate-buffered saline. Results: In the acquisition phase of the Morris water maze test, the latencies of the injection groups were significantly delayed, but recovered within 1 week. In the probe test, 2 of 4 indices (time in the platform zone and the number of crossings) were significantly different in the 8-µl injection group. Immunohistochemistry revealed the extent of cholinergic destruction. Activity-regulated cytoskeleton-associated protein and glutamate decarboxylase expression significantly decreased in the frontal cortex (8- and 10-µl groups), but not in the hippocampus. Conclusion: Spatial memory impairment was associated with cholinergic basal forebrain injury as well as frontocortical GABAergic hypofunction and synaptic plasticity deceleration.

show abstract

Parvalbumin-lmmunoreactive Neurons in the Neocortex are Resistant to Degeneration in Alzheimerʼs Disease

Cited by 171 publications

References 0 publications

Altered synaptic circuitry in the human temporal neocortex removed from epileptic patients

Altered synaptic circuitry in the human temporal neocortex removed from epileptic patients

Loss of calcium and increased apoptosis within the same neuron

Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin

Contact Info

Product

Resources

About