Parvalbumin expression in the claustrum of the adult dog. An immunohistochemical and topographical study with comparative notes on the structure of the nucleus

Pirone, Andrea; Magliaro, Chiara; Giannessi, Elisabetta; Ahluwalia, Arti

doi:10.1016/j.jchemneu.2015.02.004

Cited by 18 publications

(13 citation statements)

References 58 publications

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“…The PV‐ir neurons, not observed in the rostral sections, were in fact localized in the caudalmost region. This particular pattern was not reported in other species, in which PV‐ir neurons were seen throughout the Cl (rat: Druga et al ., ; monkey: Reynhout & Baizer, ; cat: Hinova‐Palova et al ., ; Rahman and Baizer, ; human: Hinova‐Palova et al ., ; human, chimpanzee, macaque: Pirone et al ., ; dog: Pirone et al ., ). A link between the Cl and the visual cortex has been clearly demonstrated in the cat, in which the postero‐dorsal zone of the nucleus is called the visual Cl, due to its connections with the visual cortex (LeVay & Sherk, ), that also contains PV‐ir neurons (Rahman & Baizer, ), and.…”

Section: Discussionmentioning

confidence: 97%

The Claustrum of the Pig: An Immunohistochemical and a Quantitative Golgi Study

Pirone

Miragliotta

Cozzi

et al. 2019

The Anatomical Record

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Despite increasing interest in the claustrum (Cl) over the last decades, its function is still a puzzling problem. Among the experimental species of potential use in Cl research, the pig is considered an interesting model, because of the similarities of its brain with the corresponding cortical and subcortical human structures. The swine Cl presents a peculiar morphology, characterized by a wide posterior enlargement, ideal for physiological investigations. There is a wealth of data on general anatomy, cytoarchitecture, and chemo architecture of the Cl, but much less is known about the dendritic morphometry of its neurons. Dendritic length and branching pattern are key features to understand the organization of the microcircuitry, and thus the delineation of the structure-function relationships of the Cl. To this effect, we undertook (a) a quantitative study of the dendrites of the spiny neurons of the swine Cl, employing the Golgi staining; and (b) an immunohistochemical analysis to describe the distribution of the parvalbumin (PV)immunoreactive interneurons throughout the same nucleus. Taken together, the results that we report here show that the dendritic architecture and the distribution of the PV expressing interneurons change when the Cl of this species changes its shape along the rostro-caudal axis, thus suggesting a potentially specific function for the large posterior puddle. Anat Rec, 302:1638-

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Section: Discussionmentioning

confidence: 97%

The Claustrum of the Pig: An Immunohistochemical and a Quantitative Golgi Study

Pirone

Miragliotta

Cozzi

et al. 2019

The Anatomical Record

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“…Notwithstanding, some regions reported to be associated with AD are not interpreted by displacement field. Those areas include caudate nucleus ( Montagne et al, 2015 ), claustrum ( Pirone et al, 2015 ), lentiform nucleus ( Dong et al, 2015b ), subcallosal gyrus ( Dong et al, 2015b ), and subthalamic nucleus ( De Reuck et al, 2014 ). Why are those areas not detected by our DF method?…”

Section: Discussionmentioning

confidence: 99%

Detection of Alzheimer’s disease by displacement field and machine learning

Zhang

Wang

2015

PeerJ

107

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Aim. Alzheimer’s disease (AD) is a chronic neurodegenerative disease. Recently, computer scientists have developed various methods for early detection based on computer vision and machine learning techniques.Method. In this study, we proposed a novel AD detection method by displacement field (DF) estimation between a normal brain and an AD brain. The DF was treated as the AD-related features, reduced by principal component analysis (PCA), and finally fed into three classifiers: support vector machine (SVM), generalized eigenvalue proximal SVM (GEPSVM), and twin SVM (TSVM). The 10-fold cross validation repeated 50 times.Results. The results showed the “DF + PCA + TSVM” achieved the accuracy of 92.75 ± 1.77, sensitivity of 90.56 ± 1.15, specificity of 93.37 ± 2.05, and precision of 79.61 ± 2.21. This result is better than or comparable with not only the other proposed two methods, but also ten state-of-the-art methods. Besides, our method discovers the AD is related to following brain regions disclosed in recent publications: Angular Gyrus, Anterior Cingulate, Cingulate Gyrus, Culmen, Cuneus, Fusiform Gyrus, Inferior Frontal Gyrus, Inferior Occipital Gyrus, Inferior Parietal Lobule, Inferior Semi-Lunar Lobule, Inferior Temporal Gyrus, Insula, Lateral Ventricle, Lingual Gyrus, Medial Frontal Gyrus, Middle Frontal Gyrus, Middle Occipital Gyrus, Middle Temporal Gyrus, Paracentral Lobule, Parahippocampal Gyrus, Postcentral Gyrus, Posterior Cingulate, Precentral Gyrus, Precuneus, Sub-Gyral, Superior Parietal Lobule, Superior Temporal Gyrus, Supramarginal Gyrus, and Uncus.Conclusion. The displacement filed is effective in detection of AD and related brain-regions.

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“…Anaesthesia was induced and maintained with isoflurane (5% and 1-2%, respectively) combined 30 with oxygen (2 L/minute). Animals were then placed in a stereotaxic frame (Kopf, Tujunga, CA, USA) 31 and chloramphenicol eye ointment (Martindale Pharmaceuticals, Romford, UK) was topically applied 32 to the eyes to protect the cornea. Pre-surgical analgesia (Metacam, 1 mg/kg; Boehringer Ingelheim, 33…”

Section: Surgical Procedures 29mentioning

confidence: 99%

“…series used for visualization of the tracers and, in some cases, remaining series were used for further 32 immunofluorescence staining ( Table 1). 33…”

Section: Immunofluorescence Staining 28mentioning

confidence: 99%