Parvalbumin-containing interneurons do not innervate granule cells in the olfactory bulb

Crespo, Carlos; Blasco-Ibáñez, José Miguel; Marqués-Marí, Ana Isabel; Martı́nez-Guijarro, Francisco José

doi:10.1097/00001756-200108080-00052

Cited by 21 publications

(23 citation statements)

References 24 publications

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“…Regarding the putative functional role of Van Gehuchten cells in MOB circuitry, serial electron microscopy studies showed that VIP and/or PV processes directly innervate M/T cells (Toida et al, 1996;Crespo et al, 2001Crespo et al, , 2002. This challenges the classical scheme according to which EPL interneurons only contact granule cells (Schneider and Macrides, 1978).…”

Section: Somatostatin-ir Van Gehuchten Interneurons: Comparative Analmentioning

confidence: 94%

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

Lepousez

Csaba

Bernard

et al. 2010

J of Comparative Neurology

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Neuropeptides play a major role in the modulation of information processing in neural networks. Somatostatin, one of the most concentrated neuropeptides in the brain, is found in many sensory systems including the olfactory pathway. However, its cellular distribution in the mouse main olfactory bulb (MOB) is yet to be characterized. Here we show that approximately 95% of mouse bulbar somatostatin-immunoreactive (SRIF-ir) cells describe a homogeneous population of interneurons. These are restricted to the inner lamina of the external plexiform layer (iEPL) with dendritic field strictly confined to the region. iEPL SRIF-ir neurons share some morphological features of Van Gehuchten short-axon cells, and always express glutamic acid decarboxylase, calretinin, and vasoactive intestinal peptide. One-half of SRIF-ir neurons are parvalbumin-ir, revealing an atypical neurochemical profile when compared to SRIF-ir interneurons of other forebrain regions such as cortex or hippocampus. Somatostatin is also present in fibers and in a few sparse presumptive deep short-axon cells in the granule cell layer (GCL), which were previously reported in other mammalian species. The spatial distribution of somatostatin interneurons in the MOB iEPL clearly outlines the region where lateral dendrites of mitral cells interact with GCL inhibitory interneurons through dendrodendritic reciprocal synapses. Symmetrical and asymmetrical synaptic contacts occur between SRIF-ir dendrites and mitral cell dendrites. Such restricted localization of somatostatin interneurons and connectivity in the bulbar synaptic network strongly suggest that the peptide plays a functional role in the modulation of olfactory processing.

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Section: Somatostatin-ir Van Gehuchten Interneurons: Comparative Analmentioning

confidence: 94%

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

Lepousez

Csaba

Bernard

et al. 2010

J of Comparative Neurology

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“…1 A, soma of mitral and tufted cells (Kosaka et al, 1994;Toida et al, 1996;Crespo et al, 2001;Kosaka and Kosaka, 2007).…”

Section: Analysis Of Ob Interneuron Diversitymentioning

confidence: 99%

“…This is mediated largely through the actions of a diverse set of interneurons (Aungst et al, 2003;Lledo et al, 2005). Subpopulations of these interneurons can be characterized by their location, synaptic connectivity, morphology, firing patterns, and expression of a variety of immunomarkers (Price and Powell, 1970a,c;Pinching and Powell, 1971a;Shipley and Ennis, 1996;Crespo et al, 2001;McQuiston and Katz, 2001;Kosaka and Kosaka, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Distinct Temporal Origins of Olfactory Bulb Interneuron Subtypes

et al. 2008

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Olfactory bulb (OB) interneurons are a heterogeneous population produced beginning in embryogenesis and continuing through adulthood. Understanding how this diversity arises will provide insight into how OB microcircuitry is established as well as adult neurogenesis. Particular spatial domains have been shown to contribute specific interneuron subtypes. However, the temporal profile by which OB interneuron subtypes are produced is unknown. Using inducible genetic fate mapping of Dlx1/2 precursors, we analyzed the production of seven OB interneuron subtypes and found that the generation of each subpopulation has a unique temporal signature. Within the glomerular layer, the production of tyrosine hydroxylase-positive interneurons is maximal during early embryogenesis and decreases thereafter. In contrast, the generation of calbindin interneurons is maximal during late embryogenesis and declines postnatally, whereas calretinin (CR) cell production is low during embryogenesis and increases postnatally. Parvalbumin interneurons within the external plexiform layer are produced only perinatally, whereas the generation of 5T4-positive granule cells in the mitral cell layer does not change significantly over time. CR-positive granule cells are not produced at early embryonic time points, but constitute a large percentage of the granule cells born after birth. Blanes cells in contrast are produced in greatest number during embryogenesis. Together we provide the first comprehensive analysis of the temporal generation of OB interneuron subtypes and demonstrate that the timing by which these populations are produced is tightly orchestrated.

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“…In rat olfactory bulb, for example, immunoreactivity for non-phosphorylated neurofi lament protein labels mitral cells and tufted cells [Paxinos et al, 1999]. In several eutherian species, immunohistochemistry to the three calcium binding proteins identifi es a variety of neuron types [Briñón et al, 1992[Briñón et al, , 1997[Briñón et al, , 1999[Briñón et al, , 2001Kosaka et al, 1994;Toida et al, 1996;Alonso et al, 2001;Crespo et al, 2001;Jia and Halpern, 2004]. Immunoreactivity for tyrosine hydroxylase is intense within periglomerular cells of many eutherian species [Baker, 1986a,b;Smith et al, 1991;Brunjes et al, 1992], whereas NADPH diaphorase reactive cells have been found in superfi cial and deep short axon cells of some eutherian [Scott et al, 1987].…”

Section: Introductionmentioning

confidence: 99%

“…identifi es a wide range of cell types, including periglomerular cells, superfi cial and deep short axon cells, van Gehuchten cells, multipolar cells and horizontal cells [Kosaka et al, 1994;Toida et al, 1996;Crespo et al, 2001]. By contrast, PV immunoreactivity identifi es fewer cells in the olfactory bulb of certain primates with only a few superfi cial and deep short axon cells and some small interneurons in the EPl being labeled .…”

mentioning

confidence: 98%

Chemoarchitecture of the Monotreme Olfactory Bulb

Ashwell

2006

Brain Behav Evol

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The cyto- and chemoarchitecture of the olfactory bulb of two monotremes (shortbeaked echidna and platypus) was studied to determine if there are any chemoarchitectural differences from therian mammals. Nissl staining in conjunction with enzyme reactivity for NADPH diaphorase, and immunoreactivity for calcium binding proteins (parvalbumin, calbindin and calretinin), neuropeptide Y, tyrosine hydroxylase and non-phosphorylated neurofilament protein (SMI-32 antibody) were applied to the echidna. Material from platypus bulb was Nissl stained, immunoreacted for calretinin, or stained for NADPH diaphorase. In contrast to eutherians, no immunoreactivity for either the SMI-32 antibody or calretinin was found in the mitral or dispersed tufted cells of the monotremes and very few parvalbumin or calbindin immunoreactive neurons were found in the bulb of the echidna. On the other hand, immunoreactivity for tyrosine hydroxylase in the echidna was similar in distribution to that seen in therians, and periglomerular and granule cells showed similar patterns of calretinin immunoreactivity to eutherians. Multipolar neuropeptide Y immunoreactive neurons were confined to the deep granule cell layer and underlying white matter of the echidna bulb and NADPH diaphorase reactivity was found in occasional granule cells, fusiform and multipolar cells of the inner plexiform and granule cell layers, as well as underlying white matter. Unlike eutherians, no NPY immunoreactive or NADPH diaphorase reactive neurons were seen in the glomerular layer. The bulb of the echidna was comparable in volume to prosimians of similar body weight, and its constituent layers were highly folded. In conclusion, the monotreme olfactory bulb does not show any significant chemoarchitectural dissimilarities from eutheria, despite differences in mitral/tufted cell distribution.

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Parvalbumin-containing interneurons do not innervate granule cells in the olfactory bulb

Cited by 21 publications

References 24 publications

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

The Distinct Temporal Origins of Olfactory Bulb Interneuron Subtypes

Chemoarchitecture of the Monotreme Olfactory Bulb

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