Partners in defense, vitamin E and vitamin C

Chan, Alvin C.

doi:10.1139/y93-109

Cited by 340 publications

(202 citation statements)

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“…4 Additionally, ascorbate can regenerate ␣-tocopherol (the most active form of vitamin E) from the tocopherol radical, thus decreasing the vitamin E radical by means of a recycling mechanism. [36][37][38] Other areas of ongoing research have investigated the anti-inflammatory and wound-healing effects of ascorbic acid as well as its photopreventive effects against cutaneous malignancy. Very little information is available on the topographic changes in photodamaged facial skin associated with topical ascorbic acid application.…”

Section: Commentmentioning

confidence: 99%

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Traikovich

1999

Arch Otolaryngol Head Neck Surg

142

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Objective: To determine the efficacy of topical ascorbic acid application in treating mild to moderate photodamage of facial skin using an objective, computerassisted image analysis of skin surface topography and subjective clinical, photographic, and patient selfappraisal questionnaires.Design: A 3-month, randomized, double-blind, vehiclecontrolled study.Setting: Facial plastic surgery private practice.Patients: Nineteen evaluable volunteer sample patients aged between 36 and 72 years with Fitzpatrick skin types I, II, and III who were in good physical and mental health with mild to moderately photodamaged facial skin were considered for analysis.Intervention: Coded, unmarked medications were randomly assigned to the left and right sides of each subject's face, one containing the active agent, topical ascorbic acid (Cellex-C high-potency serum; Cellex-C International, Toronto, Ontario), the other, the vehicle serum (Cellex-C International). Three drops (0.5 mL) of each formulation were applied daily to the randomly assigned hemifaces over the 3-month study period. Treatment assignments were not disclosed to subjects, clinicians, or personnel involved in analyzing skin replicas. Main Outcome Measures:Specific clinical parameters were evaluated and graded on a 0-to 9-point scale (0, none; 1-3, mild; 4-6, moderate; and 7-9, severe). Reference photographs were used to standardize grading criteria. Overall investigator scores were compared with baseline and graded as excellent (much improved), good (improved), fair (slightly improved), no change, or worse. Patient self-appraisal questionnaires rated the degree of improvement (much improved, improved, slightly improved, no change, or worse) and reported adverse effects (burning, stinging, redness, peeling, dryness, discoloration, itching, and rash). Standard photographs were taken at baseline, including anteroposterior and left and right oblique views to facilitate subsequent clinical evaluations, and at the end of therapy for comparison. Optical profilometry analysis was performed on the skin surface replicas of the lateral canthal (crow's feet) region, comparing baseline to end-of-study specimens. Using this computer-based system, the resulting image was digitally analyzed, and numeric values were assigned to reflect surface features. The parameters obtained included R z , R a , and shadows. These values provided objective data that document pretreatment and posttreatment texture changes proportional to the degree of wrinkling, roughness, and other surface irregularities.Results: Optical profilometry image analysis demonstrated a statistically significant 73.7% improvement in the R a and shadows north-south facial axis values with active treatment greater than vehicle control, as well as a trend for improvement in the R z north-south facial axis parameter, showing a 68.4% greater improvement of active treatment vs vehicle control. Clinical assessment demonstrated significant improvement with active treatment greater than control for fine wrinkling, tactile roughnes...

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Section: Commentmentioning

confidence: 99%

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Traikovich

1999

Arch Otolaryngol Head Neck Surg

142

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“…Indeed, some studies of Chagas disease 39,40 have shown that one of the host mechanisms in the acute phase of infection involves upregulation of the antioxidant defense system through GSH. This finding suggests that GSH production might constitute a major defense mechanism against oxidative stress in the acute phase of the disease, which would act to maintain the sulfhydryl groups of proteins, eliminate peroxides, and regenerate antioxidant vitamins such as vitamins C and E.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant therapy in experimental Chagas disease

Tieghi

Manca

Garcia

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Stimulation of inflammatory mediators such as cytokines and chemokines may cause oxidative stress in Chagas disease. In this study, we evaluated the merit of vitamins C and E as antioxidant therapy to minimize the oxidative stress-induced damage in an experimental model of Chagas disease. Methods: Ninety-six Swiss mice were infected with Trypanosoma cruzi QM2 and treated with vitamins C, E, or both (C/E) for 60 and 120 days, and their effects compared to placebo administration were evaluated in the acute and chronic disease phases. Results: There was no difference in parasitemia among treatment groups. However, histological analysis showed more severe inflammation in the skeletal muscle in the vitamin supplementation groups at both the acute and chronic phases. Biochemical analyses during the acute phase showed increased ferric-reducing ability of plasma (FRAP) and glutathione (GSH) levels in the vitamin C and C/E groups. In the chronic phase, a decrease in GSH levels was observed in the vitamin E group and a decrease in thiobarbituric acid reactive substances (TBARS) was observed in the vitamin C/E group. Moreover, there was a decrease in TBARS in the cardiac tissues of the vitamin C and C/E groups compared to that of the placebo group, although this level was greater in the vitamin E group than in the vitamin C group. Conclusions: The antioxidant action of vitamins C and E reduced oxidative stress in both the acute and chronic phases of Chagas disease, with a marked effect from joint administration, indicating their inherent synergism.

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“…Since dietary vitamin C intake was similar in all subjects, the low plasma ascorbate concentrations in smokers probably re¯ects an increased ascorbate turnover (Brown et al, 1997). Kinetic studies demonstrate an intracellular interaction between vitamin C and vitamin E whereby the membrane-bound oxidized vitamin E is regenerated nonenzymically by ascorbate at the membrane cytosol interface (Chan, 1993).…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte membrane fatty acid composition of smokers and non-smokers: effects of vitamin E supplementation

Brown¹,

Morrice²,

Duthie³

1998

Eur J Clin Nutr

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Objective: Adequate dietary intakes of vitamin E and essential polyunsaturated fatty acids are important to maintain cell membrane integrity, and de®ciencies have been associated with smoking related cardiovascular disease. Suf®cient vitamin E is required to prevent free radical mediated peroxidation of membrane lipids. Consequently, smokers may have a greater requirement for this antioxidant. To investigate, we assessed the concurrent in¯uences of smoking, vitamin E supplementation and red blood cell (RBC) PUFA composition on the susceptibility of the cells to lipid peroxidation in adult males. Design and subjects: Thirty male smokers and thirty male non-smokers were randomly ascribed to daily 280 mg vitamin E or placebo supplements for 10 weeks. RBC were analysed at weeks 0 and 10 for fatty acid methyl esters, vitamin E, and their susceptibility to in vitro H 2 O 2 induced lipid peroxidation. Results: Concentrations of essential fatty acids (EFA) in RBC were lower in smokers than in non-smokers. Supplementation with vitamin E increased levels of RBC EFA in smokers to match those of non-smokers. Furthermore, the ratio of vitamin E to PUFA in RBC from smokers and non-smokers was inversely correlated with their susceptibility to peroxidation. Conclusions: An adequate vitamin E to PUFA ratio is required to protect cell membranes from oxidative damage. The signi®cant correlation between susceptibility to peroxidation and the PUFA content of RBC before supplementation suggests an inadequate intake of vitamin E in relation to PUFA intake. Moreover, the requirement for vitamin E appears to be greater in smokers than in non-smokers.

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Partners in defense, vitamin E and vitamin C

Cited by 340 publications

References 0 publications

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Evaluation of antioxidant therapy in experimental Chagas disease

Erythrocyte membrane fatty acid composition of smokers and non-smokers: effects of vitamin E supplementation

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