Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

Kumar, Kathryn Prame; Nicholls, Alyce J.; Wong, Connie Hoi Yee

doi:10.1007/s00441-017-2753-2

Cited by 305 publications

(220 citation statements)

References 156 publications

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“…Patrolling monocytes and tissue‐resident macrophages are part of the first line of defense upon viral infection. These specialized phagocytic cells play the role of first responders against a wide range of pathogens and, upon activation, release immune modulators such as TNFα, IL‐1β, and IL‐6 which trigger localized inflammation . Macrophages and monocytes are one of the first immune subsets identified in the synovial tissue cellular infiltrate of CHIKV‐infected patients .…”

Section: Role Of Cell‐mediated Immunity In the Development Of Chikv‐imentioning

confidence: 99%

Pathogenic Th1 responses in CHIKV‐induced inflammation and their modulation upon Plasmodium parasites co‐infection

Torres‐Ruesta

Teo

Chan

et al. 2019

Immunological Reviews

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The induction of polyarthritis and polyarthralgia is a hallmark of arthritogenic alphavirus infections, with an exceptionally higher morbidity observed with chikungunya virus (CHIKV). While the mechanisms underlying these incapacitating acute symptoms remain partially understood, the progression to chronic conditions in some cases remains unanswered. The highly pro‐inflammatory nature of alphavirus disease has suggested the involvement of virus‐specific, joint‐infiltrating Th1 cells as one of the main pathogenic mediators of CHIKV‐induced joint pathologies. This review summarizes the role of cell‐mediated immune responses in CHIKV pathogenesis, with a specific focus on pro‐inflammatory Th1 responses in the development of CHIKV joint inflammation. Furthermore, due to the explosive nature of arthritogenic alphavirus outbreaks and their recent expansion across the world, co‐infections with other highly prevalent pathogens such as malaria are likely to occur but the pathological outcomes of such interactions in humans are unknown. This review will also discuss the potential impact of malaria co‐infections on CHIKV pathogenesis and their relevance in alphavirus control programs in endemic areas.

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Section: Role Of Cell‐mediated Immunity In the Development Of Chikv‐imentioning

confidence: 99%

Pathogenic Th1 responses in CHIKV‐induced inflammation and their modulation upon Plasmodium parasites co‐infection

Torres‐Ruesta

Teo

Chan

et al. 2019

Immunological Reviews

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“…Specifically, reviews will provide insight regarding our understanding of how neutrophils interact with, and modulate the behavior of monocytes and macrophages within health and disease (Kumar et al 2018). These interactions have proven to be centrally important with respect to the development of an inflammatory vs. a reparative tissue environment.…”

mentioning

confidence: 99%

Neutrophils: multitasking first responders of immunity and tissue homeostasis

2018

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From an evolutionary perspective, neutrophils are one of oldest immune cell types and represent a key first responder to infection and tissue injury (Leiding 2017). These early immune components first appear in simple invertebrates, such as cnidarians, as cells called amebocytes. In higher invertebrates, these primordial neutrophils take the form of hemocytes, cells that possess many of the functions of both neutrophils (phagocytosis, degranulation) and platelets (ability to initiate clotting of hemolymph). In vertebrates, these frontline immune cells take the form of the classic neutrophil, a granular phagocyte that is rapidly recruited to sites of infection or injury. Diverging from its evolutionary roots, the vertebrate neutrophil has lost much of its hemostatic function and appears to be dedicated to the host response to infection/injury.In many ways, the rapid and robust response of neutrophils to infection has placed this leukocyte in the spotlight as the prototypical cell of the innate immune response. Upon infection or injury, neutrophils are recruited en masse, migrating from the bloodstream, crossing the endothelium, and entering the tissue interstitium where these cells then home to the specific site of challenge. Over the past century, these foot soldiers of the innate immune system have been studied in detail, providing great insight as to how the host recognizes pathogens, how cells are recruited to specific tissue beds, how immune cells are able to directly kill a variety of pathogens (lysosomes, proteases, reactive-oxygen species), and how immune cells inflict the collateral damage associated with inflammation. These studies began to define a clear role for the neutrophil as a short lived, non-discriminating killer that, while key to controlling infectious agents, often resulted in significant harm to self-tissues in an effort to ensure the clearance of the pathogen. For decades, this view of neutrophils as an unsophisticated Bthug^of the innate immune system predominated, and, for the most part, limited efforts to search for, and understand, other functions of the neutrophil.Despite the common view that we had already fully mapped the function of the neutrophil, research persisted and, with the advent of new techniques and technology (conditional genetic knock-out animals, blocking and depleting antibodies, multi-color flow cytometry, etc.), our understanding of these prototypical innate immune cells has changed dramatically over the last two decades. In particular, perhaps no single technique has advanced our understanding of neutrophils biology better than intravital imaging. What began with Julius Cohnheim nearly 150 years ago, using a simple white-light microscope to study blood flow and leukocyte behavior in a frog's tongue, has evolved to embrace cuttingedge technology allowing for the visualization multiple cell types, pathogens, and effector functions in real-time, in the living animal with resolution never believed to be possible. With this approach we have mapped cell recruitment, adhe...

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“…Both methods of macrophage depletion corroborate to show striking increases in neutrophil recruitment to the liver after brain-LPS microinjection. These results suggest that neutrophils may compensate for macrophage loss, or that they are normally constrained by macrophages in part possibly by being phagocytosed as they become impaired or die, as has been described in an immune response [65]. However, these infiltrating neutrophils do not appear to fully make up for macrophage functions as they do not exhibit the same dynamic movements or lasting occupation in the liver during the hepatic response to brain-LPS (Fig.…”

Section: Liver Infiltration By Macrophages Is Driven and Coordinated mentioning

confidence: 62%

Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration

Jiménez

Earley

Hamlin

et al. 2020

Preprint

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Many brain pathologies are associated with liver damage, but a direct link has long remained elusive. Here, we establish a new paradigm for interrogating brain-periphery interactions by leveraging zebrafish for its unparalleled access to the intact whole animal for in vivo analysis in real time after triggering focal brain inflammation. We reveal that drainage of inflammatory macromolecules from the brain led to a strikingly robust peripheral infiltration of macrophages into the liver independent of Kupffer cells. We further demonstrate that this macrophage recruitment requires signaling from the cytokine IL-34, Toll-like receptor adaptor protein MyD88, and neutrophils. These results highlight the ability for circulation of brain-derived substances to serve as a rapid mode of communication from brain to the liver. Understanding how the brain engages the periphery at times of danger may offer new perspectives for detecting and treating brain pathologies.

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Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

Cited by 305 publications

References 156 publications

Pathogenic Th1 responses in CHIKV‐induced inflammation and their modulation upon Plasmodium parasites co‐infection

Pathogenic Th1 responses in CHIKV‐induced inflammation and their modulation upon Plasmodium parasites co‐infection

Neutrophils: multitasking first responders of immunity and tissue homeostasis

Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration

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