Partner preference behavior of estrous female rats affected by castration of tethered male incentives

Broekman, Mark; Bruin, M. de; Smeenk, J.M.J.; Slob, A. Koos; Schoot, P. van der

doi:10.1016/0018-506x(88)90005-0

Cited by 38 publications

(18 citation statements)

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“…The discrepancy between our preference test results and the results by [6], in which estrous female rats spend more time with orchidectomized males than with intact males, could be explained by the difference in the test situation. [6] 35 allowed female rats to sexually interact with tethered males, whereas our preference test depended solely on remote cues, olfactory and auditory. In our paced mating test, sham operated females spent less time in the male compartment depending on the intensity of sexual stimuli they received.…”

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confidence: 49%

“…It is obvious that there is a close parallelism between the paced mating test and passive avoidance learning. Assuming that genital stimulation is aversive [6], entrance to the male compartment and subsequent sexual stimuli from the male would have an aversive value comparable to footshock. The loss of passive avoidance learning in the MeA lesioned females testifies to disturbances in emotional coping with aversive stimuli without affecting anxiety or emotionality as shown in the open field 21.…”

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confidence: 99%

“…In our paced mating test, sham operated females spent less time in the male compartment depending on the intensity of sexual stimuli they received. Because intact males become by far the partners preferred by females in estrus when intromissions are prevented by vaginal occlusion, excessive genital stimulation has been regarded as aversive to females [6]. Similarly, intromission during 40 copulation correlates negatively with subsequent appetitive sexual behavior [9,15].…”

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The Medial Amygdala Controls the Coital Access of Female Rats: A Possible Involvement of Emotional Responsiveness

Kondo

Sakuma

2005

JJP

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Partner preference and paced mating tests were accomplished in ovariectomized female rats 10 following bilateral radiofrequency lesions in the medial amygdala. Open field behavior and passive avoidance learning were also examined to investigate the underlying behavioral mechanism. Partner preference was determined in a chamber located between castrated and sexually active males. Airborne olfactory cues were presented to the female through small holes on the partition. The lesion diminished preference for the odor of sexually active males over that of castrated males, even after injection with 15 high-dose of estrogen. On the other hand, in a paced mating test, the lesioned females without estrogen treatment showed a significantly shorter latency for entering the male's compartment in a two-compartment apparatus, which allowed the females, but not the males, to cross the barrier through a narrow opening at the bottom. However, administration of estrogen and progesterone reduced the effect. The lesion had no effect on emotionality or exploratory behavior in an open field test, but impaired passive avoidance learning 20 capability. We suggest that a male poses an inherent threat to a female. The seemingly incompatible results of partner preference and paced mating tests can be compromised if the male is inherently aversive to the female; this emotional response can be removed by the medial amygdala lesion. [The Japanese Journal of Physiology 55(6), 2005, in press] Key words: female sexual behavior, partner preference, paced mating, medial amygdala, estrogen. 25In the wild rat, sexual interactions are initiated and paced by females in estrus through patterns of approach toward and withdrawal from sexually active males [15]. Although some components of female sexual behavior imply the appetitive aspect, the initiative by females, however, is obscured by male active pursuit when tested in ordinary laboratory situation such as in an aquarium. To solve this problem, several researchers are directing attention to paced mating situation, mimicking wild environment [14, 38]. In the 30 paced mating, female rats can stay a place inaccessible for males and visit a compartment for mating with stimulus males. The situation allows females to regulate their own copulatory pacing without disturbance by males. Pacing behavior, then, is thought to reflect their sexual motivation.Olfactory preference toward sexually active males is also affected by female sexual motivation. When presented odors of sexually active and inactive males, sexually motivated females spend longer time to 35 explore odors from sexually active males. This test also measures female sexual motivation without influence by stimulus male behavior [43].Since the body of our knowledge on neural circuits for female sexual behavior has been accumulated by studying lordosis, a reflexive component of female rat sexual behavior, some researchers start on reevaluation of the regulatory mechanisms of female sexual behavior by means of these test paradigms [16, 4...

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The Medial Amygdala Controls the Coital Access of Female Rats: A Possible Involvement of Emotional Responsiveness

Kondo

Sakuma

2005

JJP

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“…However, it has been reported that receptive female rats occasionally do not choose sexually active males when both sexually active males and females are available in a direct contact situation [9]. The female avoidance of male rats may be caused by an aversive component of sexual interaction since prevention of intromission by taping the vagina abolishes this female tendency and directs the females to sexually active male rats [9,10].…”

Section: Introductionmentioning

confidence: 98%

“…The female avoidance of male rats may be caused by an aversive component of sexual interaction since prevention of intromission by taping the vagina abolishes this female tendency and directs the females to sexually active male rats [9,10].…”

Section: Introductionmentioning

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Transient reversal of olfactory preference following castration in male rats: Implication for estrogen receptor involvement

Xiao

Chiba

Sakuma

et al. 2015

Physiology & Behavior

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Effects of neonatal 17α-ethinyloestradiol exposure on female-paced mating behaviour in the rat

et al. 2017

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Correct perinatal oestrogen levels are critical for sexual differentiation. For example, perinatal exposure to oestrogen causes masculinization and defeminization of the brain in female rats and also induces delayed effects after maturation characterized by early onset of abnormal oestrus cycling. However, the mechanisms underlying the above effects of oestrogen remain to be fully determined. 17α-ethinyloestradiol (EE), a common synthetic oestrogen widely used in oral contraceptives, binds specifically to oestrogen receptors. In this study, we demonstrated the effects of a single neonatal injection of high- or low-dose EE on reproductive behaviours. Female rats within 24 h after birth were subcutaneously injected with sesame oil, EE (0.02, 2 mg kg ) and 17β-oestradiol (E ) (20 mg kg ). Between 11 and 15 weeks of age, sexual behaviour was tested twice in a paced mating situation. Latency to enter, lordosis and soliciting behaviour were recorded. Both high-dose EE- and E -treated females showed a significantly lower lordosis quotient, decreased soliciting behaviours, increased rejection and fighting numbers. Accessibility to males was also delayed by neonatal E exposure, although it was shortened by high-dose EE exposure. In contrast, low-dose EE-treated females did not exhibit impaired sexual behaviour. These results suggest that single neonatal exposure to a high dose of EE or E disturbs the normal development of the female brain, resulting in impaired sexual behaviours in a female-paced mating situation. Besides, the differences noted between high-dose EE- and E -treated females might be caused by different affinities of the oestrogen receptors, metabolic rates or mechanisms of action. Copyright © 2017 John Wiley & Sons, Ltd.

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Partner preference behavior of estrous female rats affected by castration of tethered male incentives

Cited by 38 publications

References 25 publications

The Medial Amygdala Controls the Coital Access of Female Rats: A Possible Involvement of Emotional Responsiveness

The Medial Amygdala Controls the Coital Access of Female Rats: A Possible Involvement of Emotional Responsiveness

Transient reversal of olfactory preference following castration in male rats: Implication for estrogen receptor involvement

Effects of neonatal 17α-ethinyloestradiol exposure on female-paced mating behaviour in the rat

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