Partitioning of upper airway resistance in Friesian and double-muscled calves

Gustin, Pascal; Bakima, M.; Lekeux, Pierre; Lomba, F.; Woestijne, K. P. Van de

doi:10.1016/0034-5687(87)90084-3

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…3), although BW'B calves were heavier than HF calves. Nevertheless, since dead space of the respiratory system is probably smaller in BW'B calves than in HF calves due to narrower airways (GUSTIN et al, 1987b(GUSTIN et al, , 1988a, and since BWB calves breathed with lower RR and larger VT than HF calves (Fig. 2), a greater deal of Ve is devoted to alveolar ventilation in double-muscled calves in our study.…”

Section: Resultsmentioning

confidence: 59%

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Pulmonary Function Values in Friesian and Double‐Muscled Calves during Acute Poikilocapnic Hypoxia

Amory

Desmecht

Lindén

et al. 1997

Journal of Veterinary Medicine Series A

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Summary The effects of an acute non‐isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein‐Friesian (HF) calves and in 7 double‐muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves.

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Section: Resultsmentioning

confidence: 59%

“…More precisely, double-muscled animals show a higher ratio of Ru.w to R L (76%) compared to conventional cattle (62%). Furthermore,GUSTIN et al (1987a) partitioned the lobar resistance (RV in vitro of HF and BWB calves into central resistance…”

mentioning

confidence: 99%

Pulmonary Function Values in Friesian and Double‐Muscled Calves during Acute Poikilocapnic Hypoxia

Amory

Desmecht

Lindén

et al. 1997

Journal of Veterinary Medicine Series A

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“…Therefore, the authors hypothesise that the use of a metal end-piece in contrast to the more commonly distributed soft plastic tubes increased the risk of perforation, possibly in combination with inappropriate tubing. Although Belgian Blue calves have a more narrow rima glottis than Holstein-Friesian calves, there is no reasonable evidence that this breed is more susceptible to oesophageal perforation (Gustin and others 1987). …”

Section: Discussionmentioning

confidence: 99%

Cervical oesophageal perforation by a colostrum tube with metal end‐piece in neonatal calves

Pardon

Valgaeren

Chiers

et al. 2015

Vet Record Case Reports

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In a three-month period, a Belgian Blue beef herd was confronted with three unexplained mortalities in neonatal calves, characterised by the development of a marked cervical swelling. A fourth case was referred for closer examination. On clinical examination, the animal showed a diffuse cervical swelling with oedema and crepitation, depression, anorexia and muffled lung sounds. A barium contrast-enhanced radiograph showed diffusion of contrast liquid from the oesophagus into the surrounding tissues, consistent with oesophageal perforation. Postmortem examination showed a fibrino-necrotising (peri)oesophagitis, tracheitis and myositis, pyothorax, pneumomediastinum and pericardial emphysema. A perforating tear was present in the ventral oesophagus, 15 cm caudal from the larynx. The cause was an inappropriate tubing technique of the farmer and possibly the use of an oesophageal feeder with metal end-piece.

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“…Detailed study of airway resistance has demonstrated higher nasopharyngeal and laryngeal resistance but normal pulmonary resistance in comparison with normal muscled animals [26]. Macroglossia is one of the first reported and primary features of the WBS [1,2].…”

Section: Discussionmentioning

confidence: 99%

“Double-Muscle” Trait in Cattle: A Possible Model for Wiedemann-Beckwith Syndrome

Best

Gilbert‐Barness

Gerrard

et al. 2006

Fetal and Pediatric Pathology

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The Wiedemann-Beckwith syndrome (WBS) was first described in 1963 as a group of anomalies involving primarily macrosomia, macroglossia, and omphalocele. Histologic studies of WBS show nesidioblastosis of the pancreas, adrenocortical cytomegaly, and persistent metanephric blastema of the kidney. Multiple lines of evidence indicate that the human 11p15.5 region is the locus of abnormality in WBS. Insulin-like growth factor II (IGF-2) frequently has been considered a candidate gene, and expression of IGF-2 is known to be significantly delayed in fetal skeletal muscle of double-muscle (DM) cattle. Other candidate genes recently have been proposed for WBS. A number of recessive alleles in the bovine myostatin gene (GDF8, mapped to bovine chromosome 2 and apparently orthologous to the human 2q22 region) have been shown to be responsible for DM. Recently the first human case of deficient GDF8 function has been reported, confirming the importance of this gene. Bovine IGF-2 has been sequenced and localized to chromosome 25. The primary purpose of this study was to compare and contrast histologic findings in DM and WBS. Immunohistochemical staining confirms changes similar to nesidioblastosis in the pancreas. Other dysplastic changes of a cystic nature are seen in the adrenal. The renal histology of DM fetuses did not appear significantly different than controls.

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Partitioning of upper airway resistance in Friesian and double-muscled calves

Cited by 12 publications

References 9 publications

Pulmonary Function Values in Friesian and Double‐Muscled Calves during Acute Poikilocapnic Hypoxia

Pulmonary Function Values in Friesian and Double‐Muscled Calves during Acute Poikilocapnic Hypoxia

Cervical oesophageal perforation by a colostrum tube with metal end‐piece in neonatal calves

“Double-Muscle” Trait in Cattle: A Possible Model for Wiedemann-Beckwith Syndrome

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