Partitioning of quencher ions in the micellar microenvironment of polyoxyethylene nonyl phenol

The Physicochemical Parameters of Marker Compounds and Vehicles for Use in In Vitro Percutaneous Absorption Studies

“…This non-ionic surfactant is much less toxic to human skin than are ionic surfactants. Therefore, its application in the pharmaceutical industry may become more extensive in the future (21)(22)(23). The suitability of Igepal CA-630 for use in permeation experiments was previously tested by Schreiber et al (3), who investigated the influence of the composition of receptor and donor media on permeation and on the viability of one of the reconstructed epidermis models, EpiDerm™ (3).…”

“…The order also suggests different locations of the sample molecules within the micelles. Ghosh et al (21)(22)(23) proposed a structure for the Igepal micelle, comprising a hydrophilic corona composed mainly of ethylene oxide units, and a dehydrated interior formed by the nonyl phenol moieties. Testosterone has a higher water solubility, and therefore its partitioning in the microenvironment of highly hydrated sites within the aggregate would be expected.…”

Surfactant and Temperature Effects in Tyrosine/Pyridoxine Hydrochloride Systems

“…The study on micellar characteristics and the environmental effects is useful to search with the use of an appropriate fluorescent probe [11]. The fluorescence study of fluorophore in micelles has been used extensively to characterize conformational changes [12], the location of the probe molecule within micelles [13]. Particularly, the fluorescence resonance energy transfer (FRET), a distance dependent phenomenon is applicable to get spatial proximity between donor and acceptor molecules and provide a structure where it is possible to get high local concentration in the micellar environment [14][15][16][17].…”

Substituent effect on the emission behavior of thiazolidinedione derivatives in cationic and anionic micellar media

“…The knowledge of the structure of the micelles, the local environment, the local concentration and the relative orientation of the solubilized molecules is of fundamental importance in understanding the nature of the solubilization and the physical and chemical behavior of the solubilized species [6,7]. Micelles, which are used as membrane biomimetic agents, gain importance by virtue of their capacity to provide a matrix for arranging the reaction sequentially for efficient interaction, i.e., they help in compartmentalization of the reactants dynamically [8][9][10][11][12][13][14][15][16][17]. Water molecules, which are tightly bound to the surfactant head groups of micelles, resemble the hydrophilic pockets of enzymes and have high viscosities, low mobilities and polarities [18,19].…”