Partitioning of pulmonary function in rabbits during cholinergic stimulation

Fuller, S. D.; Freed, Arthur N.

doi:10.1152/jappl.1995.78.4.1242

Cited by 6 publications

(2 citation statements)

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“…Measurement of RL. Measurements of RL were obtained by using a forced-oscillation method similar to that previously described (17). Briefly, with the ventilator momentarily stopped, airflow (V ) was recorded with a pneumotachograph attached to the tracheal tube and was oscillated sinusoidally at 4 Hz for 2 s by a loudspeaker while we simultaneously measured transpulmonary pressure (Ptp).…”

Section: Experimental Techniquesmentioning

confidence: 99%

Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure

Freed

Cueto

Pryor

1999

Journal of Applied Physiology

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We examined the effects of ozone (O(3)) and endogenous antioxidant transport on canine peripheral airway function, central airway function, epithelial integrity, and inflammation. Dogs were either untreated or pretreated with probenecid (an anion-transport inhibitor) and exposed for 6 h to 0.2 parts/million O(3). Peripheral airway resistance (Rpa) and reactivity (DeltaRpa) were monitored in three sublobar locations before and after exposure to either air or O(3). Pulmonary resistance and transepithelial potential difference in trachea and bronchus were also recorded. Bronchoalveolar lavage fluid (BALF) was collected before, during, and after exposure. O(3) increased Rpa and DeltaRpa only in probenecid-treated dogs and in a location-dependent fashion. Pulmonary resistance and potential difference in bronchus increased after O(3) exposure regardless of treatment. O(3) markedly increased BALF neutrophils only in untreated dogs. With the exception of hexanal, O(3) did not alter any BALF constituent examined. Probenecid reduced BALF ascorbate, BALF protein, and plasma urate. We conclude that 1) a 6-h exposure to 0.2 parts/million O(3) represents a subthreshold stimulus in relation to its effects on peripheral airway function in dogs, 2) antioxidant transport contributes to the maintenance of normal airway tone and reactivity under conditions of oxidant stress, 3) O(3)-induced changes in Rpa and DeltaRpa are dependent on location, and 4) peripheral airway hyperreactivity and inflammation reflect independent responses to O(3) exposure. Finally, although anion transport mitigates the effect of O(3) on peripheral airway function, it contributes to the development of airway inflammation and may represent a possible target for anti-inflammatory prevention or therapy.

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Section: Experimental Techniquesmentioning

confidence: 99%

Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure

Freed

Cueto

Pryor

1999

Journal of Applied Physiology

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“…Vagal reactivity predominantly regulates the resistance of peripheral airways during inspiration (6). The HeringBreuer reflex may be abolished during acutely developed cerebral ischemia and restored by recovery of ischemic cerebral processes (1,20).…”

Section: Discussionmentioning

confidence: 99%

The role of vagal nerve root injury on respiration disturbances in subarachnoid hemorrhage

Çakır¹,

Atalay²,

Çakır³

et al. 2014

Turkish Neurosurgery

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AIm:We examined whether there is a relationship between vagal nerve root injury and the severity of respiration disorders associated with subarachnoid hemorrhage (SAH). mAterIAl and methOds:This study was conducted on 20 rabbits. Experimental SAH was induced by injecting homologous blood into the cisterna magna. During the experiment, electrocardiography and respiratory rhythms were measured daily. After the experiment, any axonal injury or changes to the arterial nervorums of the vagal nerves were examined. All respiratory irregularities and vagal nerve degenerations were statistically analyzed.results: Normal respiration rate, as measured in the control group, was 30±6 bpm. In the SAH-induced group, respiration rates were initially 20±4 bpm, increasing to 40±9/min approximately ten hours later, with severe tachypneic and apneic variation. In histopathological examinations, axon density of vagal nerves was 28500±5500 in both control and sham animals, whereas axon density was 22250±3500 in survivors and 16450±2750 in dead SAH animals. The severity of axonal degeneration of vagal nerves was greater in the six dead animals than in the survivors.COnClusIOn: If vagal nerves are lesioned, the muscles of respiration are paralyzed and respiratory reflexes are disrupted. That the ischemic and mechanical factors created by SAH cause vagal nerve root injury and respiration disorders may be inevitable and fatal. BulGulAr: Kontrol grubunda ölçüldüğü şekilde normal solunum hızı 30±6 dk şeklindeydi. SAK indüklenmiş grupta solunum hızları başlangıçta 20±4 dk iken, on saat sonrasında şiddetli takipneik ve apneik varyasyonla 40±9/dk değerine yükseldi. Histopatolojik incelemelerde vagal sinirlerin akson yoğunluğu hem kontrol hem taklit (sham) deneklerinde 28500±5500 iken yaşayan SAK deneklerinde 22250±3500 ve ölü SAK deneklerinde 16450±2750 bulundu. Vagal sinirlerde aksonal dejenerasyonun şiddeti 6 ölü denekte yaşayanlardan daha fazlaydı. sOnuÇ: Vagal sinirlerde lezyon oluşursa, solunum kasları felce uğrar ve solunum refleksleri bozulur. SAK'nın oluşturduğu iskemik ve mekanik faktörlerin vagal sinir kök hasarı ve solunum bozuklukları oluşturması kaçınılmaz ve ölümcül olabilir.

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Understanding Pulmonary Mechanics Using The Forced Oscillations Technique

Lutchen

Suki

Bioengineering Approaches to Pulmonary Physiology and Medicine

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Partitioning of pulmonary function in rabbits during cholinergic stimulation

Cited by 6 publications

References 0 publications

Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure

Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure

The role of vagal nerve root injury on respiration disturbances in subarachnoid hemorrhage

Understanding Pulmonary Mechanics Using The Forced Oscillations Technique

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