1995
DOI: 10.1152/jappl.1995.78.4.1242
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Partitioning of pulmonary function in rabbits during cholinergic stimulation

Abstract: Our goal was to partition whole lung resistance (RL) and cholinergic reactivity in rabbits into central airway, peripheral airway, and alveolar tissue (Rt) resistances by using forced oscillation (2 Hz), a retrograde catheter, and an alveolar capsule. Central and peripheral airway resistances accounted for approximately 80% of the baseline RL. However, immediately after acetylcholine challenge, Rt was negative. Bilateral vagal stimulation made Rt negative when the capsule was located on the left lung and not o… Show more

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Cited by 6 publications
(2 citation statements)
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“…Measurement of RL. Measurements of RL were obtained by using a forced-oscillation method similar to that previously described (17). Briefly, with the ventilator momentarily stopped, airflow (V ) was recorded with a pneumotachograph attached to the tracheal tube and was oscillated sinusoidally at 4 Hz for 2 s by a loudspeaker while we simultaneously measured transpulmonary pressure (Ptp).…”
Section: Experimental Techniquesmentioning
confidence: 99%
“…Measurement of RL. Measurements of RL were obtained by using a forced-oscillation method similar to that previously described (17). Briefly, with the ventilator momentarily stopped, airflow (V ) was recorded with a pneumotachograph attached to the tracheal tube and was oscillated sinusoidally at 4 Hz for 2 s by a loudspeaker while we simultaneously measured transpulmonary pressure (Ptp).…”
Section: Experimental Techniquesmentioning
confidence: 99%
“…Vagal reactivity predominantly regulates the resistance of peripheral airways during inspiration (6). The HeringBreuer reflex may be abolished during acutely developed cerebral ischemia and restored by recovery of ischemic cerebral processes (1,20).…”
Section: Discussionmentioning
confidence: 99%