Particulate matter is associated with sputum culture conversion in patients with culture-positive tuberculosis

Chen, Kuan Yuan; Chuang, Kai Jen; Liu, Hui Chiao; Lee, Kang Yun; Feng, Po Hao; Su, Chien Ling; Lin, Chii Lan; Lee, Chun Nin; Chuang, Hsiao Chi

doi:10.2147/tcrm.s92927

Cited by 16 publications

(9 citation statements)

References 17 publications

(22 reference statements)

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“…A study in Taipei found that increased concentration of PM 10 increased the incidence of culture-positive TB, which is consistent with our results (Chen et al, 2016). However, the effect of PM 10 did not appear to be associated with TB in other studies in nothern California (Smith et al, 2016) and South Korea (Hwang et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

Long-term effect of exposure to ambient air pollution on the risk of active tuberculosis

Mao

et al. 2019

International Journal of Infectious Diseases

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To explore the long-term effect of exposure to ambient air pollution on the risk of active tuberculosis (TB). Methods: We constructed a distributed-lag nonlinear model (DLNM) to evaluate the relatively long-term influence of outdoor PM 2.5 , PM 10 , SO 2 and NO 2 exposure on active TB risk in the city of Lianyungang in Jiangsu Province, China. Results: There were 7,282 TB cases reported in the study area during 2014-2017, with annual median (interquartile range) concentrations of PM 2.5 , PM 10 , SO 2 and NO 2 at 45.86 (34.57-64.14) mg/m 3 , 85.43 (62.86-116.14) mg/m 3 , 22.00 (15.71-30.86) mg/m 3 and 30.00 (23.29-38.57) mg/m 3 , respectively. The single-pollutant model showed that for each 10 mg/m 3 increase in concentration, the cumulative relative risk of TB was 1.12 (lag 0-24 weeks, 95% CI: 1.03-1.22) for PM 2.5 with reference to 35 mg/m 3 ; 1.11 (lag 0-21 weeks, 95% CI: 1.06-1.17) for PM 10 with reference to 70 mg/m 3 ; 1.37 (lag 0-20 weeks, 95% CI: 1.16-1.62) for SO 2 with reference to 60 mg/m 3 ; and 1.29 (lag 0-22 weeks, 95% CI: 1.11-1.49) for NO 2 with reference to 40 mg/m 3. In the multipollutant model considering both PM 10 and NO 2 , the association remained significant. Conclusions: Our results revealed a potential association between outdoor exposure to PM 2.5 , PM 10 , SO 2 , and NO 2 and active TB. Considering that people from developing countries continue to be exposed to both severe outdoor air pollution and high rates of latent TB infection, the association between worsening air pollution and active TB deserves further attention.

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Section: Discussionsupporting

confidence: 91%

Long-term effect of exposure to ambient air pollution on the risk of active tuberculosis

Mao

et al. 2019

International Journal of Infectious Diseases

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“…It showed that outdoor air pollutants and meteorological factors had short-term effects on the daily TB case in this study. Air pollutants, including SO 2 , NO 2 , and PM 10 , had a positive effect on daily TB case with a lag effect in this study, which are similar to the conclusions of previous studies in most parts (Yao et al 2019;Zhu et al 2018;Álvaro-Meca et al 2016;Chen et al 2016;Lai et al 2016;Smith et al 2014;Smith et al 2016;Hwang et al 2014). Exposure to PM 10 and NO 2 was positively associated with the increased TB risk in North California and Taiwan (Smith et al 2014;Smith et al 2016).…”

Section: Discussionsupporting

confidence: 89%

“…Epidemiologic studies, mostly conducted in developed countries or regions, reported significant associations between longterm or short-term exposure to ambient air pollutants and outpatient visits or hospital admissions for TB, indicating particulate matter, nitrogen dioxide (NO 2 ), and carbon monoxide (CO) were positively associated with TB risk (Yao et al 2019;Zhu et al 2018;Álvaro-Meca et al 2016;Chen et al 2016;Iwai et al 2005;Jassal et al 2013;Lai et al 2016;Peng et al 2017;Shilova and Glumnaia 2004;Smith et al 2014;Smith et al 2016;Tremblay 2007). What's more, the previous finding suggested that initial TB outpatient visits were associated with −2.0% (95% CI: −3.2%, −0.8%) and −4.6% (95% CI: − 6.8%, −2.4%) changes with each 10μg/m 3 increase in SO 2 at lag 3 and lag 0-3 days in Ningbo, China (Ge et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of ambient air pollution and meteorological factors on tuberculosis in semi-arid area, northwest China: a case study in Lanzhou

Niu

Qi²,

Zhao

et al. 2021

Environ Sci Pollut Res

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To investigate the short-term effects of ambient air pollution and meteorological factors on daily tuberculosis (TB), semi-parametric generalized additive model was used to assess the impacts of ambient air pollutants and meteorological factors on daily TB case from 2005 to 2010 in Chengguan District, Lanzhou, China. Then a non-stratification parametric model and a stratification parametric model were applied to study the interactive effect of air pollutants and meteorological factors on daily TB. The results show that sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), and particulate matter with aerodynamic diameter less than 10μm (PM 10 ) were positively correlated with daily TB case; the excess risk (ER) and 95% confidence interval (CI) were 1.79% (0.40%, 3.20%), 3.86% (1.81%, 5.96%), and 0.32% (0.02%, 0.62%), respectively. Daily TB case was positively correlated with maximum temperature, minimum temperature, average temperature, vapor pressure, and relative humidity, but negatively correlated with atmospheric pressure, wind speed, and sunshine duration. The association with average temperature was the strongest, whose ER and 95% CI were 4.43% (3.15%, 5.72%). In addition, there were significant interaction effects between air pollutants and meteorological factors on daily TB case.

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“…PM 2.5 has been reported to affect lung pathology, with smear positive TB patients being more exposed to PM 2.5 than smear negative TB patients [ 34 ]. Moreover, chronic exposure to PM 10 ≥ 50 μg/m 3 was associated with an increase in the time required for TB positive sputum culture conversion [ 35 ]. In the present study, people exposed to IAP from household solid fuel use were more likely to have smear positive TB than bacteriologically confirmed TB, and exposure to smoke from tobacco were also associated with bacteriologically confirmed TB.…”

Section: Discussionmentioning

confidence: 99%

Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Dorjravdan

Kouda

Boldoo

et al. 2021

Environ Health Prev Med

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Background Tuberculosis (TB) and indoor air pollution (IAP) are equally critical public health issues in the developing world. Mongolia is experiencing the double burden of TB and IAP due to solid fuel combustion. However, no study has assessed the relationship between household solid fuel use and TB in Mongolia. The present study aimed to assess the association between household solid fuel use and TB based on data from the Mongolian National Tuberculosis Prevalence Survey (MNTP Survey). Method The MNTP Survey was a nationally representative population-based cross-sectional survey targeting households in Mongolia from 2014 to 2015, with the aim of evaluating the prevalence of TB. The survey adopted a multistage cluster sampling design in accordance with the World Health Organization prevalence survey guidelines. Clusters with at least 500 residents were selected by random sampling. A sample size of 98 clusters with 54,100 participants was estimated to be required for the survey, and 41,450 participants were included in the final analysis of the present study. A structured questionnaire was used to collect information on environmental and individual factors related to TB. Physical examination, chest X-ray, and sputum examinations were also performed to diagnose TB. Results The use of solid fuels for heating (adjusted odds ratio (aOR): 1.5; 95% confidence interval (CI): 1.1–2.1), male gender (aOR: 2.2; 95% CI: 1.6–3.2), divorced or widowed (aOR: 2.6; 95% CI: 1.7–3.8), daily smoker (aOR: 1.8; 95% CI: 1.3–2.5), contact with an active TB case (aOR: 1.7; 95% CI: 1.2–2.3), being underweight (aOR: 3.7; 95% CI: 2.4–5.7), and previous history of TB (aOR: 4.3; 95% CI: 3.0–6.1) were significantly associated with bacteriologically confirmed TB after adjusting for confounding variables. Conclusion The use of solid fuels for heating was significantly associated with active TB in Mongolian adults. Increased public awareness is needed on the use of household solid fuels, a source of IAP.

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Particulate matter is associated with sputum culture conversion in patients with culture-positive tuberculosis

Cited by 16 publications

References 17 publications

Long-term effect of exposure to ambient air pollution on the risk of active tuberculosis

Long-term effect of exposure to ambient air pollution on the risk of active tuberculosis

Short-term effects of ambient air pollution and meteorological factors on tuberculosis in semi-arid area, northwest China: a case study in Lanzhou

Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

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