Particulate Matter Immunomodulatory Effects on Autoantibody Development in New Zealand Mixed Mice

Hassani, Mary; Brown, Jared M.; Morandi, Maria T.; Holian, Andrij

doi:10.1080/15476910490505644

Cited by 5 publications

(4 citation statements)

References 18 publications

(49 reference statements)

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“…Regarding animal models of SLE, no kidney alterations were observed in a study that treated NZM mice with instilled PM [59]. On the other hand, studies with silica particles demonstrated kidney impairments with development of proteinuria and renal histopathologic alterations in lupus-prone mice instilled with silica [52,58].…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies using a different mice model for SLE (New Zealand Mixed, NZM), have shown that instillation of silica particles increased mortality due to renal complications [58] and instillation of particulate matter (PM1648 and PM2.5, dose 500 μg) also increased mortality of NZM, but with absence of renal impairments [59]. In our model, NZBW mice exposed to CAP presented early development of proteinuria and the weight of the kidney was increased compared to NZBW exposed to FA, although histopathological scores, fibrosis and C3 complement deposition on kidneys were not different between these groups.…”

Section: Discussionmentioning

confidence: 99%

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Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

et al. 2021

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Background Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

et al. 2021

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show abstract

Section: Discussionmentioning

confidence: 99%

“…Furthermore, risk of nephropathies, including lupus nephritis, were associated with long term exposure to air pollutants in China [77]. Regarding to animal models of SLE, no kidney alterations were observed in a study that treated NZM mice with instilled PM [56]. On the other hand, studies with silica particles demonstrated kidney impairments with development of proteinuria and renal histopathologic alterations in lupus-prone mice instilled with silica solutions [55,60].…”

Section: Discussionmentioning

confidence: 99%

Chronic Exposure to PM2.5 Aggravates SLE Manifestations in Lupus-Prone Mice

Yariwake

Quiroz²,

Santos

et al. 2020

Preprint

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Background: Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600µg/m³ of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed.Results: Female NZBW mice exposed to CAP presented decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA.Conclusions: This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

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Toxicological Effects of Fine Particulate Matter (PM2.5): Health Risks and Associated Systemic Injuries—Systematic Review

Garcia

Santa-Helena

Falco

et al. 2023

Water Air Soil Pollut

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Previous studies focused on investigating particulate matter with aerodynamic diameter ≤ 2.5 µm (PM 2.5 ) have shown the risk of disease development, and association with increased morbidity and mortality rates. The current review investigate epidemiological and experimental findings from 2016 to 2021, which enabled the systemic overview of PM 2.5 ’s toxic impacts on human health. The Web of Science database search used descriptive terms to investigate the interaction among PM 2.5 exposure, systemic effects, and COVID-19 disease. Analyzed studies have indicated that cardiovascular and respiratory systems have been extensively investigated and indicated as the main air pollution targets. Nevertheless, PM 2.5 reaches other organic systems and harms the renal, neurological, gastrointestinal, and reproductive systems. Pathologies onset and/or get worse due to toxicological effects associated with the exposure to this particle type, since it can trigger several reactions, such as inflammatory responses, oxidative stress generation and genotoxicity. These cellular dysfunctions lead to organ malfunctions, as shown in the current review. In addition, the correlation between COVID-19/Sars-CoV-2 and PM 2.5 exposure was also assessed to help better understand the role of atmospheric pollution in the pathophysiology of this disease. Despite the significant number of studies about PM 2.5 's effects on organic functions, available in the literature, there are still gaps in knowledge about how this particulate matter can hinder human health. The current review aimed to approach the main findings about the effect of PM 2.5 exposure on different systems, and demonstrate the likely interaction of COVID-19/Sars-CoV-2 and PM 2.5 .

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Particulate Matter Immunomodulatory Effects on Autoantibody Development in New Zealand Mixed Mice

Cited by 5 publications

References 18 publications

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

Chronic Exposure to PM2.5 Aggravates SLE Manifestations in Lupus-Prone Mice

Toxicological Effects of Fine Particulate Matter (PM2.5): Health Risks and Associated Systemic Injuries—Systematic Review

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