Particulate matter and inflammatory skin diseases: From epidemiological and mechanistic studies

Chao, Ling; Feng, Bin; Liang, Haiyan; Zhao, Xiangmei; Song, Jie

doi:10.1016/j.scitotenv.2023.167111

Cited by 4 publications

(1 citation statement)

References 106 publications

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“…have expanded to encompass various skin problems including extrinsic aging and inflammatory skin disorders such as atopic dermatitis, acne, and psoriasis 2,3 . According to Jin et al, PM penetrates the intercellular space through the stratum spinosum in skin barrier-disrupted mouse models, 4 and Kim et al showed that PM 2.5 exposure compromised skin barrier function, resulting in increased transepidermal water loss, and enhanced the penetration of fluorescein isothiocyanate dextran in organotypic and mouse skin.…”

Section: Introductionmentioning

confidence: 99%

Effects of Siegesbeckia herba extract against particulate matter 10 (PM₁₀) in skin barrier‐disrupted mouse models

Park,

Kwack,

Yoon

et al. 2024

Skin Research and Technology

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ObjectivesSkin barrier disruption is a significant problem of the older population in an aging society. It is characterized by increased transepidermal water loss and decreased skin water content, and particulate matter (PM) is a social issue that can contribute to the exacerbation of skin inflammation. Thus, addressing this problem is urgent.MethodsSkin barrier‐disrupted mouse models were induced by two methods using acetone application or tape‐stripping. This study investigated the antioxidative and anti‐inflammatory properties of the Siegesbeckia herba extract (SHE) on PM‐induced changes in skin barrier‐disrupted mouse models. To examine changes in skin water content, inflammatory cytokines, and keratinocyte differentiation markers, mouse models were treated with vehicle 100 μL, PM10 100 μL (100 μg/mL), SHE 100 μL, or PM10 100 μL (100 μg/mL) plus SHE 100 μL.ResultsSHE preserved skin hydration in the skin barrier‐disrupted mouse models regardless of the presence of PM10. SHE also inhibited the upregulation of inflammatory cytokines such as interleukin (IL)‐1β, IL‐4, IL‐6, IL‐8, and tumor necrosis factor‐α and normalized the downregulation of keratinocyte differentiation markers against PM10 in skin barrier‐disrupted mouse models.ConclusionsThis study elucidated the therapeutic effects of SHE against PM10 in skin barrier‐disrupted mouse models.

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Section: Introductionmentioning

confidence: 99%

Effects of Siegesbeckia herba extract against particulate matter 10 (PM₁₀) in skin barrier‐disrupted mouse models

Park,

Kwack,

Yoon

et al. 2024

Skin Research and Technology

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Momordica cochinchinensis extract alleviates oxidative stress and skin damage caused by fine particulate matter

Lee,

Kim,

et al. 2024

Tissue and Cell

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Human Keratinocyte Responses to Woodsmoke Chemicals

Karim,

Yang,

Salemi

et al. 2024

Chem. Res. Toxicol.

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Air pollution consists of complex mixtures of chemicals with serious deleterious health effects from acute and chronic exposure. To help understand the mechanisms by which adverse effects occur, the present work examines the responses of cultured human epidermal keratinocytes to specific chemicals commonly found in woodsmoke. Our earlier findings with liquid smoke flavoring (aqueous extract of charred wood) revealed that such extracts stimulated the expression of genes associated with oxidative stress and proinflammatory response, activated the aryl hydrocarbon receptor, thereby inducing cytochrome P4501A1 activity, and induced cross-linked envelope formation, a lethal event ordinarily occurring during terminal differentiation. The present results showed that furfural produced transcriptional responses resembling those of liquid smoke, cyclohexanedione activated the aryl hydrocarbon receptor, and several chemicals induced envelope formation. Of these, syringol permeabilized the cells to the egress of lactate dehydrogenase at a concentration close to that yielding envelope formation, while furfural induced envelope formation without permeabilization detectable in this way. Furfural (but not syringol) stimulated the incorporation of amines into cell proteins in extracts in the absence of transglutaminase activity. Nevertheless, both chemicals substantially increased the amount of cellular protein incorporated into envelopes and greatly altered the envelope protein profile. Moreover, the proportion of keratin in the envelopes was dramatically increased. These findings are consistent with the chemically induced protein cross-linking in the cells. Elucidating mechanisms by which this phenomenon occurs may help understand how smoke chemicals interact with proteins to elicit cellular responses, interpret bioassays of complex pollutant mixtures, and suggest additional sensitive ways to monitor exposures.

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Particulate matter and inflammatory skin diseases: From epidemiological and mechanistic studies

Cited by 4 publications

References 106 publications

Effects of Siegesbeckia herba extract against particulate matter 10 (PM₁₀) in skin barrier‐disrupted mouse models

Effects of Siegesbeckia herba extract against particulate matter 10 (PM₁₀) in skin barrier‐disrupted mouse models

Momordica cochinchinensis extract alleviates oxidative stress and skin damage caused by fine particulate matter

Human Keratinocyte Responses to Woodsmoke Chemicals

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Particulate matter and inflammatory skin diseases: From epidemiological and mechanistic studies

Cited by 4 publications

References 106 publications

Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models

Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models

Momordica cochinchinensis extract alleviates oxidative stress and skin damage caused by fine particulate matter

Human Keratinocyte Responses to Woodsmoke Chemicals

Contact Info

Product

Resources

About

Effects of Siegesbeckia herba extract against particulate matter 10 (PM₁₀) in skin barrier‐disrupted mouse models

Effects of Siegesbeckia herba extract against particulate matter 10 (PM₁₀) in skin barrier‐disrupted mouse models