Particulate air pollution exposure during pregnancy and postpartum depression symptoms in women in Mexico City

Niedzwiecki, Megan M.; Rosa, Maria José; Solano-González, Maritsa; Kloog, Itai; Just, Allan C.; Martínez-Medina, Sandra; Schnaas, Lourdes; Tamayo‐Ortiz, Marcela; Wright, Robert O.; Téllez-Rojo, Martha M.; Wright, Rosalind J.

doi:10.1016/j.envint.2019.105325

Cited by 39 publications

(42 citation statements)

References 48 publications

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“… Sheffield et al. (2018) found that mid pregnancy exposure was related to depressive symptoms at 6 and 12 months postpartum, and Niedzwiecki et al. (2020) reported that average pregnancy exposure to PM 2.5 was associated with the actual onset of postpartum depression at 6 months.…”

Section: Discussionmentioning

confidence: 99%

“…In order to determine best practices in screening and potential targets for treatment of prenatal depression, it is essential to better understand its underlying etiology. Recent studies suggest that exposure to air pollution during pregnancy may play a role in development of depressive symptoms and postpartum depression ( Niedzwiecki et al., 2020 ; Sheffield et al., 2018 ). One study also has shown an association of exposure to particulate matter from mid to late pregnancy with higher levels of psychological distress during pregnancy ( Lin et al., 2017 ), although they did not find an association specifically with depression.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to particulate matter, prenatal depressive symptoms and HPA axis dysregulation

Ahlers

Weiss

2021

Heliyon

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Background The prevalence of depression during pregnancy is on the rise, affecting women's well-being and their children's health outcomes. Preliminary studies suggest that exposure to air pollution during pregnancy may play a role in development of depressive symptoms. In addition, pollution has been linked to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, our brain's primary stress response system. The purpose of this study was to examine the association of air pollution exposure during pregnancy to prenatal depressive symptoms. We also evaluated whether cortisol, the hormonal endpoint of HPA activation, mediated the relationship between exposure to pollution and prenatal depression. Methods Women were recruited in obstetric clinics during their third trimester of pregnancy. They completed the Patient Health Questionnaire-9 to assess depression and provided salivary samples at 4 times during the day for 2 days. Four measures of cortisol were calculated from salivary assays: average cortisol level, cortisol awakening response (CAR), diurnal cortisol slope (DCS), and area under the curve (AUC G ). We acquired data on particulate matter with a diameter of 2.5 μm (PM 2.5 ) or less within each woman's residential area from public records of the air quality control district. Structural equation modeling was used to analyze the aims. Results Increased prenatal exposure to PM 2.5 across pregnancy was associated with more severe depressive symptoms during the 3rd trimester (β = 0.14, p = 0.02). Greater PM 2.5 exposure also had significant relationships with both higher cortisol AUC G (β = 15.933, p = 0.005) and average cortisol levels (β = 0.018, p = 0.023) among women. However, no cortisol parameter appeared to mediate the relationship between PM 2.5 exposure and depressive symptoms. Conclusions Findings suggest pregnancy may be a critical window of sensitivity to PM 2.5 exposure that escalates depression risk and induces activation of the HPA axis, evidenced in greater overall cortisol concentration. Further research is needed to identify mechanisms underlying the effects of particulate matter, especially potential methylation of glucocorticoid or serotonin transporter genes that may elicit changes in both depression and the stress response system. In addition, assessment of depression appears warranted for pregnant women in regions known for high pollution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to particulate matter, prenatal depressive symptoms and HPA axis dysregulation

Ahlers

Weiss

2021

Heliyon

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“… PM 2.5 Denmark 1989 - 2014 21,057 cases Increased risk factor for CNS tumors Poulsen et al (2020) 9. PM 2.5 Mexico 2007 - 2011 509 mothers Increased the risk of Postpartum depression and neuropsychological dysfunction in mothers Niedzwiecki et al (2020) 10. PM 2.5 Utah 1986 - 2015 2,444 pediatric patients and 13,459 young adult patients with cancer Increases cancer mortality in pediatric lymphomas and CNS tumors Ou et al (2020a) 11.…”

Section: Impact Of Pm On the Nervous Systemmentioning

confidence: 99%

Role of atmospheric particulate matter exposure in COVID-19 and other health risks in human: A review

Zhu

Maharajan

Liu

et al. 2021

Environmental Research

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“…In addition, PM2.5 can play a role in depressive symptoms [25,26], stroke [20,[26][27][28][29], dementia [29], Alzheimer's disease [29], diabetes mellitus [30], and ocular diseases [31,32], but there is a lack of research in this regard. To better understand the health effects of PM2.5, research on various diseases should be actively conducted.…”

Section: Discussionmentioning

confidence: 99%

Publication trends in research on particulate matter and health impact over a 10-year period: 2009–2018

Lee

Lim

Kim

2021

Environ Anal Health Toxicol

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Particulate air pollution exposure during pregnancy and postpartum depression symptoms in women in Mexico City

Cited by 39 publications

References 48 publications

Exposure to particulate matter, prenatal depressive symptoms and HPA axis dysregulation

Exposure to particulate matter, prenatal depressive symptoms and HPA axis dysregulation

Role of atmospheric particulate matter exposure in COVID-19 and other health risks in human: A review

Publication trends in research on particulate matter and health impact over a 10-year period: 2009–2018

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