Particles and microfluidics merged: perspectives of highly sensitive diagnostic detection

Abstract

There is a growing need for diagnostic technologies that provide laboratories with solutions that improve quality, enhance laboratory system productivity, and provide accurate detection of a broad range of infectious diseases and cancers. Recent advances in micro- and nanoscience and engineering, in particular in the areas of particles and microfluidic technologies, have advanced the “lab-on-a-chip” concept towards the development of a new generation of point-of-care diagnostic devices that could significantly enhance test sensitivity and speed. In this review, we will discuss many of the recent advances in microfluidics and particle technologies with an eye towards merging these two technologies for application in medical diagnostics. Although the potential diagnostic applications are virtually unlimited, the most important applications are foreseen in the areas of biomarker research, cancer diagnosis, and detection of infectious microorganisms.

Nanomaterials for biosensing applications: a review

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Safety assessment of chronic oral exposure to iron oxide nanoparticles

“…Nowadays, IONP are employed as suitable platforms for biosensing [2], biomolecular-magnetic trapping [5], magnetic hyperthermia [6], imaging [7], drug-or gene-delivery [8][9]. There is a wide variety of IONP preparation methods providing controllable nanoparticle size and customized physical, chemical and biological functionalities without cytotoxicity drawbacks [4,[10][11][12][13][14].…”

Rapid superparamagnetic‐beads‐based automated immunoseparation of Zn‐proteins from Staphylococcus aureus with nanogram yield

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