Particle Transport in Magnetophoretic Microsystems

Furlani, Edward P.

doi:10.1002/9780470622636.ch6

Cited by 7 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The evolution of magnetic particles in an applied field can be affected by several factors, including magnetic field, viscous drag, gravity, Brownian dynamics, particle/fluid interactions, and particle-particle interactions (dipole-dipole interactions) [22][23][24]. Two different approaches (Eulerian approach and Lagrangian approach) are used to model magnetic-particle transport in fluid, based on whether the Brownian motion has a significant impact on particle dynamics.…”

Section: Introductionmentioning

confidence: 99%

Simulation of Magnetically-Actuated Functional Gradient Nanocomposites

et al. 2017

View full text Add to dashboard Cite

Abstract:Magnetically-actuated functional gradient nanocomposites can be locally modulated to generate unprecedented mechanical gradients that can be applied to various interfaces and surfaces through following the design principles of natural biological materials. However, a key question is how to modulate the concentration of magnetic particles using an external magnetic field. Here, we propose a model to obtain the gradient concentration distribution of magnetic particles and mechanical gradients. The results show that three states exist when the magnetic force changes in the z direction, including the unchanging state, the stable gradient state, and the over-accumulation state, which are consistent with experiment results. If both radial and axial magnetic forces are present, the inhomogeneity of magnetic-particle distribution in two dimensions was found to break the functional gradient. Furthermore, the size effects of a functional gradient sample were studied, which indicated that adjusting the magnetic force and diffusion constant would enable larger nanocomposites samples to generate functional gradients.

show abstract

Section: Introductionmentioning

confidence: 99%

Simulation of Magnetically-Actuated Functional Gradient Nanocomposites

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, the accurate manipulation of microscopic particles in small sample volumes is awkward and time consuming in such systems, and the ability to precisely monitor the separation process is limited. However, advances in microsystem technology have led to the development of novel integrated magnetic bioseparation microsystems that are energy efficient and ideal for the analysis and monitoring of small samples [ 22 , 29 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Bioapplicationsmentioning

confidence: 99%

Magnetic Biotransport: Analysis and Applications

Furlani

2010

Materials

Self Cite

View full text Add to dashboard Cite

Magnetic particles are finding increasing use in bioapplications, especially as carrier particles to transport biomaterials such as proteins, enzymes, nucleic acids and whole cells etc. Magnetic particles can be prepared with biofunctional coatings to target and label a specific biomaterial, and they enable controlled manipulation of a labeled biomaterial using an external magnetic field. In this review, we discuss the use of magnetic nanoparticles as transport agents in various bioapplications. We provide an overview of the properties of magnetic nanoparticles and their functionalization for bioapplications. We discuss the basic physics and equations governing the transport of magnetic particles at the micro- and nanoscale. We present two different transport models: a classical Newtonian model for predicting the motion of individual particles, and a drift-diffusion model for predicting the behavior of a concentration of nanoparticles that takes into account Brownian motion. We review specific magnetic biotransport applications including bioseparation, drug delivery and magnetofection. We demonstrate the transport models via application to these processes.

show abstract

Effects of particle–fluid coupling on particle transport and capture in a magnetophoretic microsystem

Khashan

Furlani

2011

Microfluid Nanofluid

Self Cite

View full text Add to dashboard Cite

A numerical analysis is presented of the effects of particle-fluid coupling on the transport and capture of magnetic particles in a microfluidic system under the influence of an applied magnetic field. Particle motion is predicted using a computational fluid dynamic CFD-based Lagrangian-Eulerian approach that takes into account dominant particle forces as well as two-way particle-fluid coupling. Two dimensionless groups are introduced that characterize particle capture, one that scales the magnetic and hydrodynamic forces on the particle and another that scales the distance to the magnetic field source. An analysis is preformed to parameterize capture efficiency with respect to the dimensionless numbers for both one-way and two-way particle-fluid coupling. For one-way coupling, in which the flow field is uncoupled from particle motion, correlations are developed that provide insight into system performance towards optimization. The difference in capture efficiency for one-way versus two-way coupling is analyzed and quantified. The analysis demonstrates that one-way coupling, in the dilute limit, provides a conservative estimate of capture efficiency in that it overpredicts the magnetic force needed to ensure particle capture as compared with a more rigorous fully coupled analysis. In two-way coupling there is a cooperative effect between the magnetic force and a particle-induced fluidic force that enhances capture efficiency. Thus, while one-way coupling is useful for rapid parametric screening of particle capture performance, more accurate predictions require two-way particle-fluid coupling. This is especially true when considering higher capture efficiencies and/or higher particle concentrations.

show abstract

Particle Transport in Magnetophoretic Microsystems

Cited by 7 publications

References 46 publications

Simulation of Magnetically-Actuated Functional Gradient Nanocomposites

Simulation of Magnetically-Actuated Functional Gradient Nanocomposites

Magnetic Biotransport: Analysis and Applications

Effects of particle–fluid coupling on particle transport and capture in a magnetophoretic microsystem

Contact Info

Product

Resources

About