inversion recovery, and DWI sequences). The pulvinar sign is suggestive of variant CJD. 3 DWI has been shown to be the most sensitive MR sequence. 4,5 DW-MRI may show CJD-associated lesions 3 weeks after symptoms with high sensitivity (91%) and specificity (95%), 5,6 although studies suggest that up to 80% of these abnormalities are missed, 3 like in the current case, despite previous MRI, illustrating that awareness of MRI features of CJD is insufficient.In the current case, all other complementary investigations were inconclusive. EEG can show polymorphic and repetitive slower wave discharges, characteristic bi-or triphasic paroxysmal waves, or spike-slow waves in 60% of cases, 7 but these abnormalities occur intermittently, and sensitivity of EEG periodic sharp wave complexes is only 66% with 74% specificity. 8 With 88% sensitivity and 72% specificity, a negative CSF 14-3-3 assay does not exclude CJD, depending on of the evolution of the disease and disease subtype. 9,10 Several biomarkers, including tau protein, neurospecific enolase, and S100b protein, have attracted great interest. CSF tau protein had better diagnostic accuracy than other protein detection, with 91% sensitivity and 88% specificity. 9 In the current case, a search for prion protein gene mutation was performed for several reasons. Two of the woman's children were alive, family history was missing, and clinical signs and course of the genetic form of the disease are usually comparable with those of the sporadic form.Geriatricians should recognize clinical and paraclinical signs of CJD, but diagnosis remains challenging. The clinical presentation can mimic dementia or stroke, but MRI, EEG, and biomarkers can assist in the diagnosis. According to international criteria, this woman had probable CJD, but no autopsy was performed.